CRCGN015_HEPG2_48H:P07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-aminodiphenyl 100.07 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN015_HEPG2_48H:P07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 4.50028
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 3.76223
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.55522
FSD1 fibronectin type III and SPRY domain containing 1 3.30797
ANO10 anoctamin 10 3.23249
FKBP11 FK506 binding protein 11, 19 kDa 3.07659
PRKCH protein kinase C, eta 3.05984
TIMP2 TIMP metallopeptidase inhibitor 2 2.88864
AARS1 alanyl-tRNA synthetase 1 2.72718
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.45318
CPA4 carboxypeptidase A4 2.42235
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.37621
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.25298
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 2.22268
CHPF chondroitin polymerizing factor 2.21956
UBE2A ubiquitin-conjugating enzyme E2A 2.193
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 2.19211
NAGA N-acetylgalactosaminidase, alpha- 2.1888
YARS1 tyrosyl-tRNA synthetase 1 2.18857
CUTA cutA divalent cation tolerance homolog (E. coli) 2.14325
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.07949
TMEM14A transmembrane protein 14A 2.07105
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 2.05823
CORO1A coronin, actin binding protein, 1A 2.05018
DPP4 dipeptidyl-peptidase 4 2.04891
DHRS1 dehydrogenase/reductase (SDR family) member 1 2.0248
EDNRB endothelin receptor type B 2.00161

decreased expression

Symbol Name Standardized Value
IER3 immediate early response 3 -3.92589
ISOC1 isochorismatase domain containing 1 -3.21758
PECR peroxisomal trans-2-enoyl-CoA reductase -2.96177
CXADR coxsackie virus and adenovirus receptor -2.76663
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.75819
NSUN3 NOP2/Sun domain family, member 3 -2.7299
TRIB1 tribbles pseudokinase 1 -2.6622
MT1X metallothionein 1X -2.58917
S100P S100 calcium binding protein P -2.58578
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.52678
HMGA2 high mobility group AT-hook 2 -2.48545
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -2.46816
LOC122526780 uncharacterized LOC122526780 -2.43828
SMNDC1 survival motor neuron domain containing 1 -2.42812
KIFBP kinesin family binding protein -2.42227
FAIM Fas apoptotic inhibitory molecule -2.34985
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.30134
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -2.22965
CSE1L CSE1 chromosome segregation 1-like (yeast) -2.20867
TBPL1 TBP-like 1 -2.18449
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.18082
PCNP PEST proteolytic signal containing nuclear protein -2.14388
H2AZ2 H2A.Z variant histone 2 -2.11447
RUVBL1 RuvB-like AAA ATPase 1 -2.11348
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -2.0555
CRYZ crystallin, zeta (quinone reductase) -2.04499
ZNF263 zinc finger protein 263 -2.01997
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.01406