CRCGN015_HEPG2_48H:P08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-aminodiphenyl 33.36 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN015_HEPG2_48H:P08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 3.30263
PLEKHJ1 pleckstrin homology domain containing, family J member 1 3.04773
RARS1 arginyl-tRNA synthetase 1 2.79304
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.77815
PRKX protein kinase, X-linked 2.7491
SSBP2 single-stranded DNA binding protein 2 2.6756
CRMP1 collapsin response mediator protein 1 2.40828
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 2.40318
RAG1 recombination activating gene 1 2.39311
WIF1 WNT inhibitory factor 1 2.36435
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.3317
PCDHA9 protocadherin alpha 9 2.21429
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 2.19285
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.17652
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.14713
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.12979
COL9A1 collagen, type IX, alpha 1 2.08609
TKT transketolase 2.04868
MMP2 matrix metallopeptidase 2 2.0467
GADD45B growth arrest and DNA-damage-inducible, beta 2.03474
PID1 phosphotyrosine interaction domain containing 1 2.03006
EBLN2 endogenous Bornavirus-like nucleoprotein 2 2.00002

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.97547
PUF60 poly-U binding splicing factor 60KDa -4.21066
PROM1 prominin 1 -3.93031
S100P S100 calcium binding protein P -3.91822
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.8676
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.48517
RHOB ras homolog family member B -3.42523
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.25084
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -3.14701
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.72669
MCM3 minichromosome maintenance complex component 3 -2.61862
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.52691
PIM2 Pim-2 proto-oncogene, serine/threonine kinase -2.46744
GSDMD gasdermin D -2.36006
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.31975
XPO6 exportin 6 -2.24619
RBM38 RNA binding motif protein 38 -2.22802
CH25H cholesterol 25-hydroxylase -2.19695
SCRIB scribbled planar cell polarity protein -2.19404
CCN6 cellular communication network factor 6 -2.08045
TEX10 testis expressed 10 -2.06333
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 -2.0428
FOXJ3 forkhead box J3 -2.02298
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.01682
GPR183 G protein-coupled receptor 183 -2.00201