CRCGN015_HEPG2_48H:P10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description megestrol 99.64 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

27 genes differentially expressed following the CRCGN015_HEPG2_48H:P10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.45506
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.80917
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.32079
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.2398
KAT2B K(lysine) acetyltransferase 2B 2.09451
SNX10 sorting nexin 10 2.0772
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.05352
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.035

decreased expression

Symbol Name Standardized Value
LYPLA1 lysophospholipase I -4.18858
YME1L1 YME1-like 1 ATPase -4.1223
PDLIM1 PDZ and LIM domain 1 -3.89304
PLIN2 perilipin 2 -3.38354
MAPK13 mitogen-activated protein kinase 13 -3.14267
HEATR1 HEAT repeat containing 1 -2.92094
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.84923
NT5DC2 5'-nucleotidase domain containing 2 -2.74207
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -2.65872
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.59943
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.58569
IER3 immediate early response 3 -2.39499
MTFR1 mitochondrial fission regulator 1 -2.28145
S100P S100 calcium binding protein P -2.16896
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.11072
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.09834
ELOC elongin C -2.05491
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 -2.04536
ZNF430 zinc finger protein 430 -2.02637