CRCGN015_HEPG2_48H:P19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description spironolactone 101.17 um perturbation at 48 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

632 genes differentially expressed following the CRCGN015_HEPG2_48H:P19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
H2BC21 H2B clustered histone 21 6.05989
CCDC92 coiled-coil domain containing 92 5.32468
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.6815
H2BC12 H2B clustered histone 12 4.38018
SESN1 sestrin 1 4.2145
ANKRD10 ankyrin repeat domain 10 4.01399
SKIC2 SKI2 subunit of superkiller complex 4.00824
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 3.85645
WDR19 WD repeat domain 19 3.84334
INPP1 inositol polyphosphate-1-phosphatase 3.8412
PILRB paired immunoglobin-like type 2 receptor beta 3.74575
STAP2 signal transducing adaptor family member 2 3.69581
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 3.67644
CASP3 caspase 3, apoptosis-related cysteine peptidase 3.62361
ELAC2 elaC ribonuclease Z 2 3.61279
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 3.61201
NPIPB5 nuclear pore complex interacting protein family, member B5 3.59876
TMEM50A transmembrane protein 50A 3.51519
H2AC19 H2A clustered histone 19 3.479
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 3.46887
ZGPAT zinc finger, CCCH-type with G patch domain 3.46318
MAPKBP1 mitogen-activated protein kinase binding protein 1 3.46248
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 3.45021
IGF2R insulin-like growth factor 2 receptor 3.42924
DSG2 desmoglein 2 3.38722
LOC124904942 uncharacterized LOC124904942 3.37719
TIGAR TP53 induced glycolysis regulatory phosphatase 3.36381
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 3.34981
XPC xeroderma pigmentosum, complementation group C 3.34867
NBEAL2 neurobeachin-like 2 3.33215
CLCN7 chloride channel, voltage-sensitive 7 3.32659
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 3.31089
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 3.30749
CIRSR corepressor of RBPJ and splicing regulator 3.28913
CALCOCO1 calcium binding and coiled-coil domain 1 3.26803
GAK cyclin G associated kinase 3.25208
TMEM222 transmembrane protein 222 3.21543
H2AC6 H2A clustered histone 6 3.21331
CDPF1 cysteine-rich, DPF motif domain containing 1 3.18419
RNF123 ring finger protein 123 3.14969
SIRT3 sirtuin 3 3.14083
COPS7B COP9 signalosome subunit 7B 3.13205
GOLGA8A golgin A8 family, member A 3.12831
ITFG1 integrin alpha FG-GAP repeat containing 1 3.10219
YPEL5 yippee-like 5 (Drosophila) 3.09403
IDUA iduronidase, alpha-L- 3.08865
ATG9A autophagy related 9A 3.07926
OSBPL2 oxysterol binding protein-like 2 3.06421
ZYX zyxin 3.05736
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 3.05098
ILK integrin-linked kinase 3.04932
SGSM2 small G protein signaling modulator 2 3.04906
TSPYL2 TSPY-like 2 3.0483
PNPLA6 patatin-like phospholipase domain containing 6 3.04636
E4F1 E4F transcription factor 1 3.01219
SH3TC1 SH3 domain and tetratricopeptide repeats 1 3.00937
ARL8B ADP-ribosylation factor-like 8B 3.00277
ANAPC2 anaphase promoting complex subunit 2 2.93874
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.93751
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 2.93565
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa 2.91794
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 2.91346
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.89999
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 2.89425
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 2.89373
SAFB2 scaffold attachment factor B2 2.88003
EXOC1 exocyst complex component 1 2.85818
TBC1D3G TBC1 domain family member 3G 2.85604
PLD2 phospholipase D2 2.8537
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.8535
IQSEC1 IQ motif and Sec7 domain 1 2.85113
ZBTB48 zinc finger and BTB domain containing 48 2.83869
BORCS8 BLOC-1 related complex subunit 8 2.83108
WDTC1 WD and tetratricopeptide repeats 1 2.82583
CEMIP2 cell migration inducing hyaluronidase 2 2.8243
SLC26A6 solute carrier family 26 (anion exchanger), member 6 2.81242
PLA2G4B phospholipase A2, group IVB (cytosolic) 2.80416
GCC2 GRIP and coiled-coil domain containing 2 2.80294
ATG2A autophagy related 2A 2.79039
CDIP1 cell death-inducing p53 target 1 2.78594
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.78556
GPC1 glypican 1 2.77349
CCNL2 cyclin L2 2.76829
EPS8L2 EPS8-like 2 2.75509
KDM3A lysine (K)-specific demethylase 3A 2.75206
TUBG2 tubulin, gamma 2 2.75127
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 2.7505
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 2.73267
SPATA20 spermatogenesis associated 20 2.72808
GRN granulin 2.72169
CDC34 cell division cycle 34 2.72102
TLCD3A TLC domain containing 3A 2.72018
LUC7L LUC7-like (S. cerevisiae) 2.7082
OPTN optineurin 2.70677
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 2.70207
TPCN1 two pore segment channel 1 2.68727
TYK2 tyrosine kinase 2 2.67771
FAM193B family with sequence similarity 193, member B 2.67415
CLCN6 chloride channel, voltage-sensitive 6 2.67292
HEXB hexosaminidase B (beta polypeptide) 2.66322
GORASP1 golgi reassembly stacking protein 1, 65kDa 2.65885
MOSPD1 motile sperm domain containing 1 2.65377
CAPN10 calpain 10 2.6502
CTSA cathepsin A 2.64353
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 2.64277
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 2.64215
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 2.63516
ZNF358 zinc finger protein 358 2.62671
CCS copper chaperone for superoxide dismutase 2.61913
GLB1 galactosidase, beta 1 2.61633
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 2.61478
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 2.60881
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.60549
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 2.60098
NYNRIN NYN domain and retroviral integrase containing 2.59873
CCDC90B coiled-coil domain containing 90B 2.59408
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 2.59317
DRC4 dynein regulatory complex subunit 4 2.59047
ATP13A2 ATPase type 13A2 2.5822
WIPI2 WD repeat domain, phosphoinositide interacting 2 2.5759
ZNF692 zinc finger protein 692 2.5631
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 2.56127
SH3GL1 SH3-domain GRB2-like 1 2.54323
ATMIN ATM interactor 2.54153
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 2.53883
ANKZF1 ankyrin repeat and zinc finger domain containing 1 2.52839
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 2.52723
H2BC5 H2B clustered histone 5 2.51948
FHL2 four and a half LIM domains 2 2.51494
ARID5A AT rich interactive domain 5A (MRF1-like) 2.514
CTSL cathepsin L 2.51171
GDI1 GDP dissociation inhibitor 1 2.50549
ZDHHC7 zinc finger, DHHC-type containing 7 2.5043
CDK10 cyclin-dependent kinase 10 2.50349
MAN2B2 mannosidase, alpha, class 2B, member 2 2.49724
PKD1 polycystic kidney disease 1 (autosomal dominant) 2.49719
RAB17 RAB17, member RAS oncogene family 2.4956
IL21R interleukin 21 receptor 2.48749
NPTN neuroplastin 2.47644
ZNF862 zinc finger protein 862 2.47532
CTC1 CTS telomere maintenance complex component 1 2.47221
TSC2 tuberous sclerosis 2 2.47192
ACADVL acyl-CoA dehydrogenase, very long chain 2.46816
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.46659
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 2.46535
EMC3 ER membrane protein complex subunit 3 2.46471
TOLLIP toll interacting protein 2.45765
PINK1 PTEN induced putative kinase 1 2.45765
H2AB2 H2A.B variant histone 2 2.44289
RGS11 regulator of G-protein signaling 11 2.4368
CTNS cystinosin, lysosomal cystine transporter 2.43224
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 2.42896
PPME1 protein phosphatase methylesterase 1 2.42073
MADD MAP-kinase activating death domain 2.40885
APOE apolipoprotein E 2.40811
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.40486
SPHK2 sphingosine kinase 2 2.40095
LIN37 lin-37 DREAM MuvB core complex component 2.40014
TBK1 TANK-binding kinase 1 2.39754
NOL8 nucleolar protein 8 2.39074
TRAPPC6A trafficking protein particle complex 6A 2.38504
DENND2B DENN domain containing 2B 2.38346
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 2.38291
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.37568
IFT140 intraflagellar transport 140 2.37412
CSP2 CS pseudogene 2 2.37072
CDK11A cyclin-dependent kinase 11A 2.36914
CREG1 cellular repressor of E1A-stimulated genes 1 2.35476
CRY2 cryptochrome circadian clock 2 2.35333
SLC75A1 solute carrier family 75 member 1 2.35221
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2.34901
ITGAV integrin, alpha V 2.34824
LZTR1 leucine-zipper-like transcription regulator 1 2.34745
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 2.34222
CISD1 CDGSH iron sulfur domain 1 2.34008
GABARAP GABA(A) receptor-associated protein 2.33999
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.33878
RTL8C retrotransposon Gag like 8C 2.3298
GOLGA4 golgin A4 2.32935
GOLGB1 golgin B1 2.32481
CHPF2 chondroitin polymerizing factor 2 2.32237
POLL polymerase (DNA directed), lambda 2.32023
FAM50A family with sequence similarity 50, member A 2.31861
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 2.30548
WFS1 Wolfram syndrome 1 (wolframin) 2.29878
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 2.29746
CTSD cathepsin D 2.29685
NAPSA napsin A aspartic peptidase 2.29483
DYNC2I1 dynein 2 intermediate chain 1 2.29287
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 2.28974
MAN2C1 mannosidase, alpha, class 2C, member 1 2.2873
MAEA macrophage erythroblast attacher 2.2826
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 2.27907
LMF1 lipase maturation factor 1 2.27703
PGAP6 post-GPI attachment to proteins 6 2.27218
RAB26 RAB26, member RAS oncogene family 2.27129
FURIN furin (paired basic amino acid cleaving enzyme) 2.27087
MYL9 myosin, light chain 9, regulatory 2.27048
BICRA BRD4 interacting chromatin remodeling complex associated protein 2.27022
PRCP prolylcarboxypeptidase (angiotensinase C) 2.26992
GADD45A growth arrest and DNA-damage-inducible, alpha 2.26826
EIF4A2 eukaryotic translation initiation factor 4A2 2.26547
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.25777
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit 2.25767
ANKRD11 ankyrin repeat domain 11 2.25626
H2AC25 H2A clustered histone 25 2.25495
SCRN1 secernin 1 2.24671
GSTT4 glutathione S-transferase theta 4 2.24241
PXDC1 PX domain containing 1 2.23841
ATG4B autophagy related 4B, cysteine peptidase 2.23654
SIN3B SIN3 transcription regulator family member B 2.23615
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 2.23363
SDF4 stromal cell derived factor 4 2.22876
IL4R interleukin 4 receptor 2.22846
NDEL1 nudE neurodevelopment protein 1-like 1 2.22817
PRKCD protein kinase C, delta 2.22787
MAP1S microtubule-associated protein 1S 2.2275
GALNS galactosamine (N-acetyl)-6-sulfatase 2.22258
F5 coagulation factor V (proaccelerin, labile factor) 2.21359
GABARAPL2 GABA(A) receptor-associated protein-like 2 2.21343
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 2.21278
CLN3 ceroid-lipofuscinosis, neuronal 3 2.21146
RAP1GAP2 RAP1 GTPase activating protein 2 2.21059
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.21043
LSG1 large 60S subunit nuclear export GTPase 1 2.20644
NADSYN1 NAD synthetase 1 2.20452
TRIM3 tripartite motif containing 3 2.20397
SPI1 Spi-1 proto-oncogene 2.20105
ANKRD37 ankyrin repeat domain 37 2.20027
ADAM9 ADAM metallopeptidase domain 9 2.19842
SCPEP1 serine carboxypeptidase 1 2.19467
GAS6 growth arrest-specific 6 2.19188
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 2.19027
CLK3 CDC-like kinase 3 2.18783
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 2.18649
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.18611
ZNF79 zinc finger protein 79 2.17859
ISG20 interferon stimulated exonuclease gene 20kDa 2.1771
MT1H metallothionein 1H 2.17498
EDN2 endothelin 2 2.1731
KMT2B lysine (K)-specific methyltransferase 2B 2.16552
GOLM1 golgi membrane protein 1 2.15565
LYPLA2 lysophospholipase II 2.15345
IFT20 intraflagellar transport 20 2.15127
CBR1 carbonyl reductase 1 2.14657
TBC1D10C TBC1 domain family, member 10C 2.14266
NSUN5 NOP2/Sun domain family, member 5 2.13876
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 2.13871
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2.13634
DAGLA diacylglycerol lipase, alpha 2.13542
BRDT bromodomain, testis-specific 2.13539
SCAMP4 secretory carrier membrane protein 4 2.13434
GNPDA1 glucosamine-6-phosphate deaminase 1 2.13067
HSPA1A heat shock 70kDa protein 1A 2.12941
LGMN legumain 2.12726
GBP2 guanylate binding protein 2, interferon-inducible 2.12675
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.12453
LMF2 lipase maturation factor 2 2.12443
TEX14 testis expressed 14 2.12238
GBP1 guanylate binding protein 1, interferon-inducible 2.11854
CHPF chondroitin polymerizing factor 2.11853
WDR6 WD repeat domain 6 2.11469
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 2.1112
OFD1 oral-facial-digital syndrome 1 2.10709
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.10591
AXIN1 axin 1 2.1004
H2BC4 H2B clustered histone 4 2.09776
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 2.0947
DVL3 dishevelled segment polarity protein 3 2.09171
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) 2.08783
SMNDC1 survival motor neuron domain containing 1 2.08528
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.08367
ABHD4 abhydrolase domain containing 4 2.08165
EPS8L3 EPS8-like 3 2.07913
GUCY2C guanylate cyclase 2C 2.07887
MANBA mannosidase, beta A, lysosomal 2.07792
RRAGC Ras-related GTP binding C 2.07288
CNN1 calponin 1, basic, smooth muscle 2.07169
POMP proteasome maturation protein 2.06923
ZBTB17 zinc finger and BTB domain containing 17 2.06501
MNMIP1 manchette microtubule inner protein 1 2.06312
KLHL2 kelch-like family member 2 2.06184
RAB9A RAB9A, member RAS oncogene family 2.05976
PLXNA3 plexin A3 2.0572
PRPF3 pre-mRNA processing factor 3 2.05517
CACFD1 calcium channel flower domain containing 1 2.05421
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 2.05335
PTPRT protein tyrosine phosphatase, receptor type, T 2.05333
CTSF cathepsin F 2.04979
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.04943
TP53 tumor protein p53 2.04412
RTL8A retrotransposon Gag like 8A 2.04333
TERF2IP telomeric repeat binding factor 2, interacting protein 2.0432
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 2.03945
RPS27L ribosomal protein S27-like 2.03943
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.03636
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 2.03546
NAGK N-acetylglucosamine kinase 2.0346
NUP58 nucleoporin 58 2.03179
TMEM43 transmembrane protein 43 2.02505
BAMBI BMP and activin membrane-bound inhibitor 2.02444
GSDME gasdermin E 2.02426
PCSK7 proprotein convertase subtilisin/kexin type 7 2.02046
AOPEP aminopeptidase O (putative) 2.01864
RMC1 regulator of MON1-CCZ1 2.01624
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 2.01127
PDCL3 phosducin-like 3 2.01103
KIAA0513 KIAA0513 2.0107
RNF103 ring finger protein 103 2.00898
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) 2.00736
MEGF6 multiple EGF-like-domains 6 2.00464
TUBA4A tubulin, alpha 4a 2.0042
DTX2 deltex 2, E3 ubiquitin ligase 2.00161

decreased expression

Symbol Name Standardized Value
CDC45 cell division cycle 45 -5.94928
MTERF3 mitochondrial transcription termination factor 3 -5.6135
KIF20A kinesin family member 20A -4.92763
KIF4A kinesin family member 4A -4.7787
MCM3 minichromosome maintenance complex component 3 -4.72948
MCM10 minichromosome maintenance complex component 10 -4.58799
PEX26 peroxisomal biogenesis factor 26 -4.57507
MCM6 minichromosome maintenance complex component 6 -4.38862
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -4.19158
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -4.116
MIS18A MIS18 kinetochore protein A -4.10459
PCCB propionyl CoA carboxylase, beta polypeptide -4.06238
LMNB1 lamin B1 -4.03838
CCNA2 cyclin A2 -4.01601
THAP11 THAP domain containing 11 -3.99216
KIF15 kinesin family member 15 -3.97679
HJURP Holliday junction recognition protein -3.95639
NCAPG2 non-SMC condensin II complex, subunit G2 -3.93311
OIP5 Opa interacting protein 5 -3.88555
MCM5 minichromosome maintenance complex component 5 -3.8239
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.7833
FASTKD5 FAST kinase domains 5 -3.74154
RFC2 replication factor C (activator 1) 2, 40kDa -3.68518
GINS1 GINS complex subunit 1 (Psf1 homolog) -3.67627
NEIL3 nei endonuclease VIII-like 3 (E. coli) -3.65298
FANCI Fanconi anemia, complementation group I -3.64733
WDR76 WD repeat domain 76 -3.64066
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -3.63864
BRCA1 breast cancer 1, early onset -3.58594
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -3.57734
NUCB2 nucleobindin 2 -3.551
ASF1B anti-silencing function 1B histone chaperone -3.53646
CSE1L CSE1 chromosome segregation 1-like (yeast) -3.52241
CXADR coxsackie virus and adenovirus receptor -3.51769
CDC6 cell division cycle 6 -3.49953
BORA bora, aurora kinase A activator -3.49463
CDK2 cyclin-dependent kinase 2 -3.48378
NCAPH non-SMC condensin I complex, subunit H -3.48102
STMN1 stathmin 1 -3.46107
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.45193
UNG uracil-DNA glycosylase -3.44435
LBR lamin B receptor -3.36518
ATAD2 ATPase family, AAA domain containing 2 -3.34627
DONSON downstream neighbor of SON -3.32842
DMAC2L distal membrane arm assembly component 2 like -3.31843
CDK1 cyclin-dependent kinase 1 -3.31665
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.31193
RACGAP1 Rac GTPase activating protein 1 -3.30073
BIRC5 baculoviral IAP repeat containing 5 -3.29962
MCM4 minichromosome maintenance complex component 4 -3.29281
ZNF274 zinc finger protein 274 -3.28624
VRK1 vaccinia related kinase 1 -3.24579
ZWILCH zwilch kinetochore protein -3.22483
DEPDC1 DEP domain containing 1 -3.21262
DUT deoxyuridine triphosphatase -3.20927
TOP2A topoisomerase (DNA) II alpha 170kDa -3.19823
TMPO thymopoietin -3.19771
RFWD3 ring finger and WD repeat domain 3 -3.19537
PGM1 phosphoglucomutase 1 -3.1908
ERCC6L excision repair cross-complementation group 6-like -3.17817
SNX10 sorting nexin 10 -3.17576
ELOVL6 ELOVL fatty acid elongase 6 -3.1549
FAM114A2 family with sequence similarity 114, member A2 -3.15352
USP1 ubiquitin specific peptidase 1 -3.15276
KIF11 kinesin family member 11 -3.13307
CRTAP cartilage associated protein -3.13122
RFC3 replication factor C (activator 1) 3, 38kDa -3.13042
CENPI centromere protein I -3.1287
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -3.10524
TRIP13 thyroid hormone receptor interactor 13 -3.09161
DHFR dihydrofolate reductase -3.08889
CDC7 cell division cycle 7 -3.06772
WDHD1 WD repeat and HMG-box DNA binding protein 1 -3.06392
DNA2 DNA replication helicase/nuclease 2 -3.05789
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.05662
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -3.05159
FIRRM FIGNL1 interacting regulator of recombination and mitosis -3.04749
TTK TTK protein kinase -3.02939
ARHGAP11A Rho GTPase activating protein 11A -3.01175
DET1 de-etiolated homolog 1 (Arabidopsis) -3.01057
CPNE3 copine III -2.98872
UBE2J1 ubiquitin-conjugating enzyme E2, J1 -2.98832
THAP1 THAP domain containing, apoptosis associated protein 1 -2.98142
KIF18B kinesin family member 18B -2.95989
EXO1 exonuclease 1 -2.95352
FEN1 flap structure-specific endonuclease 1 -2.93179
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -2.92221
SPC25 SPC25, NDC80 kinetochore complex component -2.91032
CDC20 cell division cycle 20 -2.9096
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -2.90674
ZWINT ZW10 interacting kinetochore protein -2.90556
PRC1 protein regulator of cytokinesis 1 -2.88803
CDT1 chromatin licensing and DNA replication factor 1 -2.88725
NUSAP1 nucleolar and spindle associated protein 1 -2.86908
SLC25A40 solute carrier family 25, member 40 -2.8657
SKA1 spindle and kinetochore associated complex subunit 1 -2.85032
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.83218
KNTC1 kinetochore associated 1 -2.82715
CENPA centromere protein A -2.81532
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -2.80705
HMGN2 high mobility group nucleosomal binding domain 2 -2.80683
KIF14 kinesin family member 14 -2.80538
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.80215
DCK deoxycytidine kinase -2.79652
TK1 thymidine kinase 1, soluble -2.78755
GINS4 GINS complex subunit 4 (Sld5 homolog) -2.77867
EXOSC2 exosome component 2 -2.77417
FBXO5 F-box protein 5 -2.77186
MCM7 minichromosome maintenance complex component 7 -2.75471
RBMX RNA binding motif protein, X-linked -2.75292
CENPE centromere protein E, 312kDa -2.74209
NUP37 nucleoporin 37kDa -2.73738
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -2.73671
S100P S100 calcium binding protein P -2.73141
ZNF134 zinc finger protein 134 -2.72651
CCNB1 cyclin B1 -2.72212
MTFR1 mitochondrial fission regulator 1 -2.72171
TPX2 TPX2, microtubule-associated -2.72059
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.68599
NUP62 nucleoporin 62kDa -2.6822
TADA2A transcriptional adaptor 2A -2.67663
JRKL JRK-like -2.67534
MPHOSPH9 M-phase phosphoprotein 9 -2.67249
DCLRE1B DNA cross-link repair 1B -2.67024
ZNF551 zinc finger protein 551 -2.67002
SRSF9 serine/arginine-rich splicing factor 9 -2.66716
CDC25C cell division cycle 25C -2.66372
TRDMT1 tRNA aspartic acid methyltransferase 1 -2.66285
TTC28 tetratricopeptide repeat domain 28 -2.64857
SDF2L1 stromal cell-derived factor 2-like 1 -2.64855
TRMT5 tRNA methyltransferase 5 -2.64788
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -2.64157
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.64054
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant -2.63409
TIPIN TIMELESS interacting protein -2.62925
HMGB2 high mobility group box 2 -2.62149
DSCC1 DNA replication and sister chromatid cohesion 1 -2.61957
KIFC1 kinesin family member C1 -2.6143
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -2.6048
ZMYM4 zinc finger, MYM-type 4 -2.60151
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.59856
URM1 ubiquitin related modifier 1 -2.5938
RRM2 ribonucleotide reductase M2 -2.58822
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.58774
RRM1 ribonucleotide reductase M1 -2.58225
ZFP30 ZFP30 zinc finger protein -2.5798
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.57717
GGCT gamma-glutamylcyclotransferase -2.57463
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.57024
CCNB2 cyclin B2 -2.56921
KIF18A kinesin family member 18A -2.55803
ATAD5 ATPase family, AAA domain containing 5 -2.55702
PLK1 polo-like kinase 1 -2.54958
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase -2.53147
SRBD1 S1 RNA binding domain 1 -2.5311
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 -2.53024
MSH6 mutS homolog 6 -2.52196
ARF6 ADP-ribosylation factor 6 -2.51915
ZMYM1 zinc finger, MYM-type 1 -2.50121
HAT1 histone acetyltransferase 1 -2.49441
RCC1 regulator of chromosome condensation 1 -2.49304
NRIP1 nuclear receptor interacting protein 1 -2.49139
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -2.48999
IER3 immediate early response 3 -2.48604
ZNF587B zinc finger protein 587B -2.48077
SNX6 sorting nexin 6 -2.47494
SMC4 structural maintenance of chromosomes 4 -2.47046
SHCBP1 SHC SH2-domain binding protein 1 -2.46747
FANCG Fanconi anemia, complementation group G -2.46162
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.45962
CEP170 centrosomal protein 170kDa -2.45921
HPRT1 hypoxanthine phosphoribosyltransferase 1 -2.45386
RBM12 RNA binding motif protein 12 -2.45338
TDP1 tyrosyl-DNA phosphodiesterase 1 -2.44994
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.44561
SFXN1 sideroflexin 1 -2.43723
XPO7 exportin 7 -2.43659
DSN1 DSN1, MIS12 kinetochore complex component -2.43512
CKS1B CDC28 protein kinase regulatory subunit 1B -2.43158
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -2.42081
RBM12B RNA binding motif protein 12B -2.42074
MCMBP minichromosome maintenance complex binding protein -2.40971
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.40224
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.4008
PLK4 polo-like kinase 4 -2.39983
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.39633
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.39403
PSAT1 phosphoserine aminotransferase 1 -2.39292
ADSL adenylosuccinate lyase -2.39004
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -2.38564
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.38354
MKI67 marker of proliferation Ki-67 -2.3832
FXN frataxin -2.38243
AURKB aurora kinase B -2.38125
HADH hydroxyacyl-CoA dehydrogenase -2.38036
KIAA0586 KIAA0586 -2.3734
BLM Bloom syndrome, RecQ helicase-like -2.36974
NUP155 nucleoporin 155kDa -2.36829
NPM3 nucleophosmin/nucleoplasmin 3 -2.36753
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -2.36624
CHEK2 checkpoint kinase 2 -2.36149
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.35188
ARB2A ARB2 cotranscriptional regulator A -2.34753
ATL2 atlastin GTPase 2 -2.34379
PRKDC protein kinase, DNA-activated, catalytic polypeptide -2.34184
AUNIP aurora kinase A and ninein interacting protein -2.34144
PYCR1 pyrroline-5-carboxylate reductase 1 -2.33598
BCAT1 branched chain amino-acid transaminase 1, cytosolic -2.3344
GLTP glycolipid transfer protein -2.33363
HEATR1 HEAT repeat containing 1 -2.3314
TOR1A torsin family 1, member A (torsin A) -2.33101
NUP93 nucleoporin 93kDa -2.3206
TSPAN7 tetraspanin 7 -2.31454
DCTN4 dynactin 4 (p62) -2.31365
NUBPL nucleotide binding protein-like -2.30939
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.30897
NGRN neugrin, neurite outgrowth associated -2.30622
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -2.29891
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -2.29807
PCLAF PCNA clamp associated factor -2.29567
SRP72 signal recognition particle 72kDa -2.28981
DCTPP1 dCTP pyrophosphatase 1 -2.28628
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.28581
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) -2.28339
MTF2 metal response element binding transcription factor 2 -2.28145
CDC27 cell division cycle 27 -2.26713
RBL1 retinoblastoma-like 1 -2.26219
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.26191
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -2.26166
STIL SCL/TAL1 interrupting locus -2.25979
OXCT1 3-oxoacid CoA transferase 1 -2.24894
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.24796
MIS18BP1 MIS18 binding protein 1 -2.24306
PIMREG PICALM interacting mitotic regulator -2.23739
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.23582
RAB33B RAB33B, member RAS oncogene family -2.2189
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.21289
RBM14-RBM4 RBM14-RBM4 readthrough -2.2058
HAUS4 HAUS augmin-like complex, subunit 4 -2.20112
ANAPC1 anaphase promoting complex subunit 1 -2.20066
GTSE1 G-2 and S-phase expressed 1 -2.19356
MRPL15 mitochondrial ribosomal protein L15 -2.19008
GPHN gephyrin -2.18995
NUP43 nucleoporin 43kDa -2.18949
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -2.18863
CENPN centromere protein N -2.1819
POLK polymerase (DNA directed) kappa -2.18021
FOXM1 forkhead box M1 -2.17766
RBMS3 RNA binding motif, single stranded interacting protein 3 -2.17682
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.17458
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) -2.17412
ZNF652 zinc finger protein 652 -2.17281
MAGT1 magnesium transporter 1 -2.17165
RAD51 RAD51 recombinase -2.17023
RBM3 RNA binding motif (RNP1, RRM) protein 3 -2.17019
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.16766
S100A1 S100 calcium binding protein A1 -2.16154
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -2.16075
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.16033
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -2.1592
RB1 retinoblastoma 1 -2.156
INTS7 integrator complex subunit 7 -2.15539
MSH2 mutS homolog 2 -2.15397
HIRIP3 HIRA interacting protein 3 -2.15388
CNPY3 canopy FGF signaling regulator 3 -2.15347
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.15271
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 -2.15179
S100A4 S100 calcium binding protein A4 -2.14946
FAM20B family with sequence similarity 20, member B -2.14637
TTF1 transcription termination factor, RNA polymerase I -2.14474
CEP55 centrosomal protein 55kDa -2.13062
STK32B serine/threonine kinase 32B -2.12355
NDC80 NDC80 kinetochore complex component -2.1189
DHRS11 dehydrogenase/reductase (SDR family) member 11 -2.11575
CDK6 cyclin-dependent kinase 6 -2.10685
RNF41 ring finger protein 41, E3 ubiquitin protein ligase -2.10682
SET SET nuclear proto-oncogene -2.10369
TOR1AIP2 torsin A interacting protein 2 -2.1022
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.098
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.09497
NUP205 nucleoporin 205kDa -2.09435
ATP5MC3 ATP synthase membrane subunit c locus 3 -2.09408
C5 complement component 5 -2.09396
NXPE3 neurexophilin and PC-esterase domain family, member 3 -2.09137
DAND5 DAN domain family member 5, BMP antagonist -2.09126
MAK16 MAK16 homolog (S. cerevisiae) -2.08309
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.08207
DEK DEK proto-oncogene -2.08167
GEMIN2 gem (nuclear organelle) associated protein 2 -2.08132
TTC27 tetratricopeptide repeat domain 27 -2.07929
CDCA4 cell division cycle associated 4 -2.0761
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -2.06996
UCK2 uridine-cytidine kinase 2 -2.06964
SNU13 small nuclear ribonucleoprotein 13 -2.06802
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.05695
KIF23 kinesin family member 23 -2.05484
TMEM100 transmembrane protein 100 -2.05244
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.04302
PRUNE1 prune exopolyphosphatase 1 -2.04177
UQCRC2 ubiquinol-cytochrome c reductase core protein II -2.04154
RPL8 ribosomal protein L8 -2.03851
HMBS hydroxymethylbilane synthase -2.03785
LRRC59 leucine rich repeat containing 59 -2.0335
AK2 adenylate kinase 2 -2.02831
PGAM4 phosphoglycerate mutase family member 4 -2.02193
PLPBP pyridoxal phosphate binding protein -2.02141
TFDP1 transcription factor Dp-1 -2.02131
CENPM centromere protein M -2.02025
PHF2 PHD finger protein 2 -2.0189
FCF1 FCF1 rRNA-processing protein -2.0175
MCTS1 malignant T cell amplified sequence 1 -2.01673
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 -2.01553
DOLPP1 dolichyldiphosphatase 1 -2.01496
CHEK1 checkpoint kinase 1 -2.01435
SCYL2 SCY1-like 2 (S. cerevisiae) -2.0119
BARD1 BRCA1 associated RING domain 1 -2.00917
PTDSS1 phosphatidylserine synthase 1 -2.00512
PPP6C protein phosphatase 6, catalytic subunit -2.00506
PRMT3 protein arginine methyltransferase 3 -2.00094