CRCGN015_HEPG2_48H:P20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description spironolactone 33.72 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

191 genes differentially expressed following the CRCGN015_HEPG2_48H:P20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
H2BC12 H2B clustered histone 12 4.03219
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.62186
ANKRD10 ankyrin repeat domain 10 3.48332
LSG1 large 60S subunit nuclear export GTPase 1 3.40301
SMNDC1 survival motor neuron domain containing 1 3.30615
H2AC6 H2A clustered histone 6 3.28512
CHN1 chimerin 1 3.25091
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.18858
ANAPC2 anaphase promoting complex subunit 2 3.18582
SESN1 sestrin 1 3.15486
ITFG1 integrin alpha FG-GAP repeat containing 1 3.08332
TFB2M transcription factor B2, mitochondrial 3.05072
XPC xeroderma pigmentosum, complementation group C 2.9931
ICAM1 intercellular adhesion molecule 1 2.9618
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 2.85845
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 2.84407
SYF2 SYF2 pre-mRNA-splicing factor 2.84292
GOLM1 golgi membrane protein 1 2.76253
GPATCH1 G patch domain containing 1 2.7354
HYOU1 hypoxia up-regulated 1 2.71573
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.66042
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.61647
URGCP upregulator of cell proliferation 2.61608
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.61026
ILK integrin-linked kinase 2.58101
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.57513
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.52087
ADAMTSL2 ADAMTS-like 2 2.51721
RNASE7 ribonuclease, RNase A family, 7 2.49773
CDPF1 cysteine-rich, DPF motif domain containing 1 2.49671
RAP1GAP2 RAP1 GTPase activating protein 2 2.45232
NAPSA napsin A aspartic peptidase 2.43845
LSR lipolysis stimulated lipoprotein receptor 2.43204
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 2.42968
CDK9 cyclin-dependent kinase 9 2.40977
TMEM50A transmembrane protein 50A 2.38935
SAFB scaffold attachment factor B 2.31689
SDF4 stromal cell derived factor 4 2.30285
SRSF4 serine/arginine-rich splicing factor 4 2.29859
AHCTF1 AT hook containing transcription factor 1 2.2774
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.25462
TP53 tumor protein p53 2.22784
THOC1 THO complex 1 2.22338
SAFB2 scaffold attachment factor B2 2.21658
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) 2.21569
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2.21464
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 2.20284
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.19798
FPGS folylpolyglutamate synthase 2.18973
NPTN neuroplastin 2.17848
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.17299
SIN3B SIN3 transcription regulator family member B 2.17092
RANBP10 RAN binding protein 10 2.16176
RAB30 RAB30, member RAS oncogene family 2.1597
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) 2.15467
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 2.1534
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 2.14463
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 2.1365
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.13615
NOL8 nucleolar protein 8 2.13009
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.12964
ZNF451 zinc finger protein 451 2.12921
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 2.12652
SNX2 sorting nexin 2 2.12398
PRPF3 pre-mRNA processing factor 3 2.11131
SPHK2 sphingosine kinase 2 2.09941
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 2.09732
CCDC28A coiled-coil domain containing 28A 2.09607
MXD1 MAX dimerization protein 1 2.08745
ARID5B AT rich interactive domain 5B (MRF1-like) 2.08664
TARS1 threonyl-tRNA synthetase 1 2.07776
ZNF559-ZNF177 ZNF559-ZNF177 readthrough 2.07507
CDC40 cell division cycle 40 2.05374
BIN3 bridging integrator 3 2.04727
SPAG1 sperm associated antigen 1 2.04061
ERO1B endoplasmic reticulum oxidoreductase 1 beta 2.04006
SPATA20 spermatogenesis associated 20 2.03834
GPATCH2 G patch domain containing 2 2.02634
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa 2.01952
ZYX zyxin 2.01198
PDCD6IP programmed cell death 6 interacting protein 2.00382
ACTN4 actinin, alpha 4 2.00336
DYSF dysferlin 2.00141

decreased expression

Symbol Name Standardized Value
CDC45 cell division cycle 45 -4.61591
TM9SF3 transmembrane 9 superfamily member 3 -3.85384
FTL ferritin, light polypeptide -3.67923
SNX7 sorting nexin 7 -3.64208
DMAC2L distal membrane arm assembly component 2 like -3.57132
TSPAN4 tetraspanin 4 -3.48831
MIS18A MIS18 kinetochore protein A -3.45992
CXADR coxsackie virus and adenovirus receptor -3.44002
OIP5 Opa interacting protein 5 -3.41057
CDC25B cell division cycle 25B -3.2156
NUCB2 nucleobindin 2 -3.16885
PEX26 peroxisomal biogenesis factor 26 -3.12401
ITGB1BP1 integrin beta 1 binding protein 1 -3.09566
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.92388
PYCR1 pyrroline-5-carboxylate reductase 1 -2.86165
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.86051
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.83052
EIF5 eukaryotic translation initiation factor 5 -2.7937
TEDC2 tubulin epsilon and delta complex 2 -2.77999
KIF4A kinesin family member 4A -2.71913
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.71411
STAMBP STAM binding protein -2.70349
NCAPG2 non-SMC condensin II complex, subunit G2 -2.64927
TK1 thymidine kinase 1, soluble -2.64511
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.63809
DENR density-regulated protein -2.63521
FANCI Fanconi anemia, complementation group I -2.60784
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -2.60398
PCCB propionyl CoA carboxylase, beta polypeptide -2.55387
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.55274
ASF1B anti-silencing function 1B histone chaperone -2.53573
CZIB CXXC motif containing zinc binding protein -2.5253
HJURP Holliday junction recognition protein -2.52076
NLRP4 NLR family, pyrin domain containing 4 -2.51174
AACS acetoacetyl-CoA synthetase -2.48862
KNTC1 kinetochore associated 1 -2.47877
MRPS16 mitochondrial ribosomal protein S16 -2.47499
KIFC1 kinesin family member C1 -2.45908
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.4505
NT5DC2 5'-nucleotidase domain containing 2 -2.43058
KIF14 kinesin family member 14 -2.42807
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.40833
HADH hydroxyacyl-CoA dehydrogenase -2.40256
KIF20A kinesin family member 20A -2.38078
AURKB aurora kinase B -2.36768
ATP5IF1 ATP synthase inhibitory factor subunit 1 -2.34177
REXO5 RNA exonuclease 5 -2.34169
ELOVL6 ELOVL fatty acid elongase 6 -2.33553
MCM3 minichromosome maintenance complex component 3 -2.32651
ANXA5 annexin A5 -2.32143
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -2.30415
LDHC lactate dehydrogenase C -2.30379
VRK1 vaccinia related kinase 1 -2.30366
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.30181
RACGAP1 Rac GTPase activating protein 1 -2.29794
CDCA8 cell division cycle associated 8 -2.29568
UBE2C ubiquitin-conjugating enzyme E2C -2.28706
CENPE centromere protein E, 312kDa -2.27713
SNX15 sorting nexin 15 -2.26894
POLK polymerase (DNA directed) kappa -2.26744
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.26262
MTCH2 mitochondrial carrier 2 -2.25134
IGF1 insulin-like growth factor 1 (somatomedin C) -2.2291
STMN1 stathmin 1 -2.22513
ZWINT ZW10 interacting kinetochore protein -2.22384
DUT deoxyuridine triphosphatase -2.21986
RBMX RNA binding motif protein, X-linked -2.2073
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -2.20424
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.20259
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.20174
CENPI centromere protein I -2.18104
MCUB mitochondrial calcium uniporter dominant negative subunit beta -2.18015
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -2.17989
ARHGAP19 Rho GTPase activating protein 19 -2.16566
CCNA2 cyclin A2 -2.16145
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.14242
BOLA1 bolA family member 1 -2.13997
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.13875
CENPM centromere protein M -2.13434
HELLS helicase, lymphoid-specific -2.12955
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.12645
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -2.11203
SPAG4 sperm associated antigen 4 -2.11129
CEP55 centrosomal protein 55kDa -2.10598
FOXM1 forkhead box M1 -2.09972
DHFR dihydrofolate reductase -2.09341
TUBA1B tubulin, alpha 1b -2.09065
MTERF3 mitochondrial transcription termination factor 3 -2.08487
RFXANK regulatory factor X-associated ankyrin-containing protein -2.08299
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.07479
CCNB2 cyclin B2 -2.0745
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.0672
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -2.06682
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -2.06268
GGCT gamma-glutamylcyclotransferase -2.06014
CGREF1 cell growth regulator with EF-hand domain 1 -2.05348
GJB1 gap junction protein, beta 1, 32kDa -2.05314
TMEM14B transmembrane protein 14B -2.05171
ARF5 ADP-ribosylation factor 5 -2.0508
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.03997
GOLGA3 golgin A3 -2.03809
BRCA1 breast cancer 1, early onset -2.03639
HMBS hydroxymethylbilane synthase -2.03623
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -2.03381
GSTZ1 glutathione S-transferase zeta 1 -2.02216
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.02079
MCM6 minichromosome maintenance complex component 6 -2.00606
STIL SCL/TAL1 interrupting locus -2.00352