CRCGN015_MCF10A.TP53.M_24H:A03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:A03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.3721
C2CD2 C2 calcium-dependent domain containing 2 5.26422
ACAA1 acetyl-CoA acyltransferase 1 3.44582
SLC4A2 solute carrier family 4 (anion exchanger), member 2 3.43686
MELK maternal embryonic leucine zipper kinase 3.36531
IGFBP3 insulin-like growth factor binding protein 3 2.76439
LSR lipolysis stimulated lipoprotein receptor 2.71107
HBA1 hemoglobin, alpha 1 2.64676
CCNF cyclin F 2.64627
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.59754
CHN1 chimerin 1 2.31589
TWNK twinkle mtDNA helicase 2.27025
TENT4A terminal nucleotidyltransferase 4A 2.25506
WASF3 WAS protein family, member 3 2.20508
ADRB2 adrenoceptor beta 2, surface 2.1996
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.19694
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 2.15644
SLC75A1 solute carrier family 75 member 1 2.14377
RTN2 reticulon 2 2.09105
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.06813
SLC61A1 solute carrier family 61 member 1 2.05787
FZD2 frizzled class receptor 2 2.01176

decreased expression

Symbol Name Standardized Value
KIF20A kinesin family member 20A -5.68739
MAPK13 mitogen-activated protein kinase 13 -5.43353
PTK2 protein tyrosine kinase 2 -3.85835
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -3.27132
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.17086
RALGDS ral guanine nucleotide dissociation stimulator -2.79431
ETFB electron-transfer-flavoprotein, beta polypeptide -2.62428
TSPAN3 tetraspanin 3 -2.48853
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.44875
CBR1 carbonyl reductase 1 -2.34083
IQGAP1 IQ motif containing GTPase activating protein 1 -2.24802
TREM1 triggering receptor expressed on myeloid cells 1 -2.24049
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.20527
RAD51C RAD51 paralog C -2.19065
HSPB2 heat shock 27kDa protein 2 -2.17729
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 -2.17584
JAKMIP2 janus kinase and microtubule interacting protein 2 -2.16197
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.11339
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.01331
AFF4 AF4/FMR2 family, member 4 -2.00068