CRCGN015_MCF10A.TP53.M_24H:A07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description potassium 1h-indol-3-yl sulfate 104.28 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

262 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:A07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 9.60425
TXNRD1 thioredoxin reductase 1 7.5553
IL1B interleukin 1, beta 7.21058
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 6.86165
CXCL2 chemokine (C-X-C motif) ligand 2 6.34725
SQSTM1 sequestosome 1 6.00418
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.954
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 5.6578
CTSL cathepsin L 5.40995
PYCR1 pyrroline-5-carboxylate reductase 1 5.03595
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.90705
UGDH UDP-glucose 6-dehydrogenase 4.73125
TNIP1 TNFAIP3 interacting protein 1 4.61285
IER3 immediate early response 3 4.47885
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 4.32923
E2F2 E2F transcription factor 2 4.21325
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 4.1454
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.9736
GLRX glutaredoxin (thioltransferase) 3.97007
SYNGAP1 synaptic Ras GTPase activating protein 1 3.83275
PHGDH phosphoglycerate dehydrogenase 3.77903
CDPF1 cysteine-rich, DPF motif domain containing 1 3.77565
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 3.70055
MVP major vault protein 3.66425
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.628
ACAA1 acetyl-CoA acyltransferase 1 3.60675
PSAT1 phosphoserine aminotransferase 1 3.36395
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.35845
GSTZ1 glutathione S-transferase zeta 1 3.303
G0S2 G0/G1 switch 2 3.24935
IL6 interleukin 6 3.18535
GARS1 glycyl-tRNA synthetase 1 3.18295
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 3.16755
SQOR sulfide quinone oxidoreductase 3.0891
CEMIP2 cell migration inducing hyaluronidase 2 3.0763
TXLNA taxilin alpha 3.0562
CASP7 caspase 7, apoptosis-related cysteine peptidase 3.04055
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 3.01573
IL1A interleukin 1, alpha 2.97795
ALAS1 5'-aminolevulinate synthase 1 2.90845
TBPL1 TBP-like 1 2.8927
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.8427
KEAP1 kelch-like ECH-associated protein 1 2.83305
WASF3 WAS protein family, member 3 2.8177
VAT1 vesicle amine transport 1 2.8152
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.7893
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.76915
UBQLN2 ubiquilin 2 2.75145
LRP10 low density lipoprotein receptor-related protein 10 2.7455
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.74078
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.7326
C1S complement component 1, s subcomponent 2.6817
MCUR1 mitochondrial calcium uniporter regulator 1 2.6782
TICAM1 toll-like receptor adaptor molecule 1 2.67625
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.64175
GCLM glutamate-cysteine ligase, modifier subunit 2.63685
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2.58895
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 2.58315
BIRC2 baculoviral IAP repeat containing 2 2.5595
TALDO1 transaldolase 1 2.5575
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.5323
NARS1 asparaginyl-tRNA synthetase 1 2.5255
FHL2 four and a half LIM domains 2 2.52105
YARS1 tyrosyl-tRNA synthetase 1 2.51625
TRIB3 tribbles pseudokinase 3 2.49485
PARP12 poly (ADP-ribose) polymerase family, member 12 2.4793
SLC30A1 solute carrier family 30 (zinc transporter), member 1 2.4623
KCTD5 potassium channel tetramerization domain containing 5 2.44855
VSIG2 V-set and immunoglobulin domain containing 2 2.44627
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.44325
CAMTA2 calmodulin binding transcription activator 2 2.41155
CANT1 calcium activated nucleotidase 1 2.39717
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.38285
ECM1 extracellular matrix protein 1 2.35965
STC2 stanniocalcin 2 2.33068
SLC67A1 solute carrier family 67 member 1 2.3176
SAA2 serum amyloid A2 2.3173
GPR137B G protein-coupled receptor 137B 2.31475
ISG15 ISG15 ubiquitin-like modifier 2.31005
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.26905
HOXA10 homeobox A10 2.2657
GARRE1 granule associated Rac and RHOG effector 1 2.25945
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.23055
TBC1D2 TBC1 domain family, member 2 2.2152
SEC16A SEC16 homolog A (S. cerevisiae) 2.1941
TSC1 tuberous sclerosis 1 2.1927
S100PBP S100P binding protein 2.1927
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.1874
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 2.17675
TSC22D1 TSC22 domain family, member 1 2.1611
SOD2 superoxide dismutase 2, mitochondrial 2.15887
LAD1 ladinin 1 2.1551
COPB1 coatomer protein complex, subunit beta 1 2.1497
NUP58 nucleoporin 58 2.14895
DUSP4 dual specificity phosphatase 4 2.11985
STK10 serine/threonine kinase 10 2.11452
TLCD3A TLC domain containing 3A 2.106
PLK3 polo-like kinase 3 2.0996
MGLL monoglyceride lipase 2.09715
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.0896
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.08465
TP53BP2 tumor protein p53 binding protein 2 2.0687
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 2.06825
NUCB2 nucleobindin 2 2.06765
BHMT2 betaine--homocysteine S-methyltransferase 2 2.06395
GABARAPL1 GABA(A) receptor-associated protein like 1 2.0637
CH25H cholesterol 25-hydroxylase 2.05235
PPIF peptidylprolyl isomerase F 2.0296
GLRX2 glutaredoxin 2 2.0262
UBE3C ubiquitin protein ligase E3C 2.02445
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.0194
RPN1 ribophorin I 2.012
FTH1 ferritin, heavy polypeptide 1 2.0083

decreased expression

Symbol Name Standardized Value
STMN1 stathmin 1 -7.9413
NLRP4 NLR family, pyrin domain containing 4 -6.71675
CORO1A coronin, actin binding protein, 1A -5.65715
CCNB2 cyclin B2 -4.93075
PSRC1 proline/serine-rich coiled-coil 1 -4.82015
KDM3A lysine (K)-specific demethylase 3A -4.2297
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -3.92325
KIF20A kinesin family member 20A -3.91745
NUSAP1 nucleolar and spindle associated protein 1 -3.89062
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.82597
MTFR1 mitochondrial fission regulator 1 -3.81935
UBE2C ubiquitin-conjugating enzyme E2C -3.7705
KIF11 kinesin family member 11 -3.6835
GRWD1 glutamate-rich WD repeat containing 1 -3.5932
ARHGAP15 Rho GTPase activating protein 15 -3.49455
TOP2A topoisomerase (DNA) II alpha 170kDa -3.46578
BIRC5 baculoviral IAP repeat containing 5 -3.41633
CDK1 cyclin-dependent kinase 1 -3.379
BPHL biphenyl hydrolase-like (serine hydrolase) -3.3608
KIF14 kinesin family member 14 -3.3475
CCNA2 cyclin A2 -3.22075
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.21895
OXCT1 3-oxoacid CoA transferase 1 -3.14175
OIP5 Opa interacting protein 5 -3.1347
PRR15L proline rich 15-like -3.12865
S100A4 S100 calcium binding protein A4 -3.12505
EAPP E2F-associated phosphoprotein -3.1166
HADH hydroxyacyl-CoA dehydrogenase -3.11643
KIF18A kinesin family member 18A -3.0348
KIF15 kinesin family member 15 -3.03175
MPC2 mitochondrial pyruvate carrier 2 -2.9907
ELP4 elongator acetyltransferase complex subunit 4 -2.98255
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.96593
SPC25 SPC25, NDC80 kinetochore complex component -2.91695
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.89915
CCNB1 cyclin B1 -2.8983
ZNF274 zinc finger protein 274 -2.8892
RFC2 replication factor C (activator 1) 2, 40kDa -2.83637
PARPBP PARP1 binding protein -2.82735
PIMREG PICALM interacting mitotic regulator -2.824
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.817
TTC33 tetratricopeptide repeat domain 33 -2.7898
DENND1C DENN/MADD domain containing 1C -2.7777
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.7068
SPDL1 spindle apparatus coiled-coil protein 1 -2.7023
PIH1D1 PIH1 domain containing 1 -2.6906
MIS18A MIS18 kinetochore protein A -2.65975
GTF2A2 general transcription factor IIA, 2, 12kDa -2.65865
GTPBP8 GTP-binding protein 8 (putative) -2.65345
HOXC4 homeobox C4 -2.65045
CD96 CD96 molecule -2.6445
CDC25C cell division cycle 25C -2.6181
TSPAN6 tetraspanin 6 -2.59347
RAD51C RAD51 paralog C -2.5542
PSIP1 PC4 and SFRS1 interacting protein 1 -2.54383
ZNF253 zinc finger protein 253 -2.483
CDC23 cell division cycle 23 -2.46125
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.4449
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.44255
SESN1 sestrin 1 -2.43895
TROAP trophinin associated protein -2.436
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.43532
CENPA centromere protein A -2.40975
ADI1 acireductone dioxygenase 1 -2.40285
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) -2.401
PRAMEF26 PRAME family member 26 -2.39665
DNM1 dynamin 1 -2.3854
TTK TTK protein kinase -2.38045
NEK2 NIMA-related kinase 2 -2.3685
IFT46 intraflagellar transport 46 -2.36815
WDR70 WD repeat domain 70 -2.35995
CEP70 centrosomal protein 70kDa -2.3589
PRUNE1 prune exopolyphosphatase 1 -2.35835
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -2.34932
MCRS1 microspherule protein 1 -2.33395
SALL2 spalt-like transcription factor 2 -2.32955
AURKB aurora kinase B -2.328
VAV3 vav 3 guanine nucleotide exchange factor -2.30735
PRPF4B pre-mRNA processing factor 4B -2.30542
FAIM Fas apoptotic inhibitory molecule -2.3017
TARP TCR gamma alternate reading frame protein -2.30138
BNC2 basonuclin 2 -2.3004
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.29595
ACTL6A actin-like 6A -2.2937
LDHD lactate dehydrogenase D -2.2934
SARS2 seryl-tRNA synthetase 2, mitochondrial -2.262
CD2 CD2 molecule -2.26035
FAM200C family with sequence similarity 200 member C -2.2577
GMCL1 germ cell-less, spermatogenesis associated 1 -2.24945
GLI3 GLI family zinc finger 3 -2.2416
MORC3 MORC family CW-type zinc finger 3 -2.23405
MKS1 Meckel syndrome, type 1 -2.2275
MED21 mediator complex subunit 21 -2.21688
CDKN3 cyclin-dependent kinase inhibitor 3 -2.2132
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.20645
NEMP1 nuclear envelope integral membrane protein 1 -2.2001
ZNF551 zinc finger protein 551 -2.1674
KIF4A kinesin family member 4A -2.16665
ANGPTL7 angiopoietin-like 7 -2.16435
DEK DEK proto-oncogene -2.16235
AURKA aurora kinase A -2.16025
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.15925
PTGES3 prostaglandin E synthase 3 (cytosolic) -2.15705
MATN2 matrilin 2 -2.15565
SSBP3 single stranded DNA binding protein 3 -2.1512
HMGB2 high mobility group box 2 -2.14925
CAMTA1 calmodulin binding transcription activator 1 -2.14665
DSN1 DSN1, MIS12 kinetochore complex component -2.14425
PTTG1 pituitary tumor-transforming 1 -2.1439
NUP133 nucleoporin 133kDa -2.1403
MNS1 meiosis-specific nuclear structural 1 -2.13845
C1QBP complement component 1, q subcomponent binding protein -2.1365
NDC80 NDC80 kinetochore complex component -2.1357
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -2.13015
DERA deoxyribose-phosphate aldolase (putative) -2.1178
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 -2.11595
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -2.1138
ZNF692 zinc finger protein 692 -2.11225
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.1095
ABI3BP ABI family, member 3 (NESH) binding protein -2.108
SNRPC small nuclear ribonucleoprotein polypeptide C -2.0996
KIF23 kinesin family member 23 -2.0971
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -2.09325
RPL39L ribosomal protein L39-like -2.08915
CD3D CD3d molecule, delta (CD3-TCR complex) -2.0876
CXADR coxsackie virus and adenovirus receptor -2.0837
ELAVL4 ELAV like neuron-specific RNA binding protein 4 -2.08285
PAIP2B poly(A) binding protein interacting protein 2B -2.07765
CENPI centromere protein I -2.0707
TMLHE trimethyllysine hydroxylase, epsilon -2.0684
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 -2.06795
NCAPG non-SMC condensin I complex, subunit G -2.06582
TMEM230 transmembrane protein 230 -2.06435
TRDMT1 tRNA aspartic acid methyltransferase 1 -2.06305
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -2.05195
SAP30 Sin3A-associated protein, 30kDa -2.04233
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.0378
RAD51AP1 RAD51 associated protein 1 -2.0368
AUNIP aurora kinase A and ninein interacting protein -2.03045
SRSF3 serine/arginine-rich splicing factor 3 -2.02693
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide -2.02675
IFT52 intraflagellar transport 52 -2.02555
IKZF5 IKAROS family zinc finger 5 (Pegasus) -2.02485
MKKS McKusick-Kaufman syndrome -2.02425
TTC1 tetratricopeptide repeat domain 1 -2.015
ZNF83 zinc finger protein 83 -2.01325
SMIM8 small integral membrane protein 8 -2.00768
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -2.00725
ERCC2 excision repair cross-complementation group 2 -2.00535