CRCGN015_MCF10A.TP53.M_24H:A08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description potassium 1h-indol-3-yl sulfate 34.76 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

89 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:A08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.38005
CASP2 caspase 2, apoptosis-related cysteine peptidase 5.19729
STIMATE STIM activating enhancer 5.1969
AMDHD2 amidohydrolase domain containing 2 5.00565
MAP7 microtubule-associated protein 7 4.94577
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 4.34075
MAST2 microtubule associated serine/threonine kinase 2 4.0447
MTA2 metastasis associated 1 family, member 2 3.8487
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 3.76695
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.58838
ACAA1 acetyl-CoA acyltransferase 1 3.55778
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.3528
PTPRS protein tyrosine phosphatase, receptor type, S 2.94605
NUTF2 nuclear transport factor 2 2.85175
CNRIP1 cannabinoid receptor interacting protein 1 2.82675
OLFML2B olfactomedin-like 2B 2.8263
RBBP5 retinoblastoma binding protein 5 2.70185
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.697
EVA1B eva-1 homolog B (C. elegans) 2.62825
TBC1D31 TBC1 domain family, member 31 2.62205
SLC39A7 solute carrier family 39 (zinc transporter), member 7 2.621
XPO4 exportin 4 2.6194
ODF2 outer dense fiber of sperm tails 2 2.5684
VSTM4 V-set and transmembrane domain containing 4 2.56465
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.5414
GADD45A growth arrest and DNA-damage-inducible, alpha 2.48255
ALAS1 5'-aminolevulinate synthase 1 2.4726
TSKU tsukushi, small leucine rich proteoglycan 2.4725
PTDSS2 phosphatidylserine synthase 2 2.4686
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.4651
IER3 immediate early response 3 2.43775
PRH1 proline-rich protein HaeIII subfamily 1 2.3938
RXYLT1 ribitol xylosyltransferase 1 2.3211
CEPT1 choline/ethanolamine phosphotransferase 1 2.31315
RBM28 RNA binding motif protein 28 2.3114
HMOX1 heme oxygenase 1 2.3101
COMP cartilage oligomeric matrix protein 2.2626
RWDD1 RWD domain containing 1 2.20025
PTCD1 pentatricopeptide repeat domain 1 2.1711
NTM neurotrimin 2.1514
GMPPB GDP-mannose pyrophosphorylase B 2.1499
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.1386
TBL3 transducin (beta)-like 3 2.13392
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.1228
TLE2 transducin-like enhancer of split 2 2.1187
FOXC1 forkhead box C1 2.1181
TBXT T-box transcription factor T 2.11575
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.10605
NPIPA6 nuclear pore complex interacting protein family, member A6 2.0986
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.09355
OSGIN1 oxidative stress induced growth inhibitor 1 2.0923
COPG1 coatomer protein complex, subunit gamma 1 2.0777
SBNO1 strawberry notch homolog 1 (Drosophila) 2.0775
IL1B interleukin 1, beta 2.05897
DPH2 DPH2 homolog (S. cerevisiae) 2.04105
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.0401

decreased expression

Symbol Name Standardized Value
FOS FBJ murine osteosarcoma viral oncogene homolog -4.93735
RGS2 regulator of G-protein signaling 2 -3.07025
SLC35E2B solute carrier family 35, member E2B -2.9111
FAIM Fas apoptotic inhibitory molecule -2.782
ATP11B ATPase, class VI, type 11B -2.7558
KIF11 kinesin family member 11 -2.61525
BASP1 brain abundant, membrane attached signal protein 1 -2.6093
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -2.5891
AGA aspartylglucosaminidase -2.38687
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.38077
RAD51C RAD51 paralog C -2.3744
CD1D CD1d molecule -2.3179
OLFML2A olfactomedin-like 2A -2.30385
RBMS3 RNA binding motif, single stranded interacting protein 3 -2.24215
THAP1 THAP domain containing, apoptosis associated protein 1 -2.2191
CAV1 caveolin 1, caveolae protein, 22kDa -2.2177
RGS4 regulator of G-protein signaling 4 -2.20725
RNF170 ring finger protein 170 -2.14585
CENPC centromere protein C -2.1441
GNG4 guanine nucleotide binding protein (G protein), gamma 4 -2.14085
ADSS2 adenylosuccinate synthase 2 -2.1359
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 -2.12415
ALCAM activated leukocyte cell adhesion molecule -2.1116
FBXO21 F-box protein 21 -2.10088
CNPY3 canopy FGF signaling regulator 3 -2.0806
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -2.05535
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -2.0545
LRRC40 leucine rich repeat containing 40 -2.0418
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -2.0218
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 -2.0177
TK1 thymidine kinase 1, soluble -2.01215
LY9 lymphocyte antigen 9 -2.00612
NDC80 NDC80 kinetochore complex component -2.001