CRCGN015_MCF10A.TP53.M_24H:A09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description potassium 1h-indol-3-yl sulfate 11.59 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

132 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:A09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIAM1 T-cell lymphoma invasion and metastasis 1 6.21193
PPARG peroxisome proliferator-activated receptor gamma 5.51475
ANO10 anoctamin 10 5.39405
RPL39L ribosomal protein L39-like 4.5445
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 4.3464
ACAA1 acetyl-CoA acyltransferase 1 3.818
CNRIP1 cannabinoid receptor interacting protein 1 3.7957
NCK2 NCK adaptor protein 2 3.3932
MAST2 microtubule associated serine/threonine kinase 2 3.27923
HMOX1 heme oxygenase 1 3.26105
CCNF cyclin F 2.88925
TXNRD1 thioredoxin reductase 1 2.7727
LYRM1 LYR motif containing 1 2.57785
TCTN1 tectonic family member 1 2.55625
LGMN legumain 2.53155
TGFBR3 transforming growth factor, beta receptor III 2.4759
TSPAN7 tetraspanin 7 2.4639
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.4463
HBA1 hemoglobin, alpha 1 2.41032
IER3 immediate early response 3 2.40365
EPCAM epithelial cell adhesion molecule 2.38215
GADD45A growth arrest and DNA-damage-inducible, alpha 2.37905
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.3532
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.33615
AGO2 argonaute RISC catalytic component 2 2.334
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.31695
PRSS3 protease, serine, 3 2.26163
SLC39A4 solute carrier family 39 (zinc transporter), member 4 2.21985
LSR lipolysis stimulated lipoprotein receptor 2.1952
REEP4 receptor accessory protein 4 2.16595
PCOLCE procollagen C-endopeptidase enhancer 2.12145
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 2.115
COX6C cytochrome c oxidase subunit VIc 2.04265
RPIA ribose 5-phosphate isomerase A 2.0391
SCML1 sex comb on midleg-like 1 (Drosophila) 2.0384
CARM1 coactivator-associated arginine methyltransferase 1 2.0352
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) 2.03315
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.00825
BCL10 B-cell CLL/lymphoma 10 2.00345

decreased expression

Symbol Name Standardized Value
WASHC4 WASH complex subunit 4 -5.02827
KRT14 keratin 14, type I -5.0
PCNA proliferating cell nuclear antigen -5.0
HSPA8 heat shock 70kDa protein 8 -4.98637
HMG20B high mobility group 20B -4.94602
GRWD1 glutamate-rich WD repeat containing 1 -4.75785
TRAPPC3 trafficking protein particle complex 3 -4.58582
GADD45B growth arrest and DNA-damage-inducible, beta -3.30252
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.99877
NGRN neugrin, neurite outgrowth associated -2.9482
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.57205
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -2.55367
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -2.5233
NOPCHAP1 NOP protein chaperone 1 -2.4905
ZNF219 zinc finger protein 219 -2.47475
EXTL2 exostosin-like glycosyltransferase 2 -2.4617
DRAM1 DNA-damage regulated autophagy modulator 1 -2.4552
MKKS McKusick-Kaufman syndrome -2.4298
LRRC36 leucine rich repeat containing 36 -2.4269
TLK2 tousled-like kinase 2 -2.41625
TMEM230 transmembrane protein 230 -2.39455
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.34965
RFX2 regulatory factor X, 2 (influences HLA class II expression) -2.33525
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.32015
CYTH2 cytohesin 2 -2.31935
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 -2.3124
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.299
AGBL2 ATP/GTP binding protein-like 2 -2.29705
RPA3 replication protein A3, 14kDa -2.26205
C1QL1 complement component 1, q subcomponent-like 1 -2.24965
ACTR5 ARP5 actin-related protein 5 homolog (yeast) -2.24872
MYBPC3 myosin binding protein C, cardiac -2.2465
KRT37 keratin 37, type I -2.23715
NEIL1 nei endonuclease VIII-like 1 (E. coli) -2.23305
ARRB2 arrestin, beta 2 -2.2256
UFC1 ubiquitin-fold modifier conjugating enzyme 1 -2.2241
NPPB natriuretic peptide B -2.2141
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 -2.20765
AOAH acyloxyacyl hydrolase (neutrophil) -2.1975
STATH statherin -2.1887
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.17
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.1677
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 -2.16505
HBD hemoglobin, delta -2.1637
DNAH6 dynein, axonemal, heavy chain 6 -2.1631
CNTLN centlein, centrosomal protein -2.1625
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.16025
LIMD1 LIM domains containing 1 -2.15545
TSNAXIP1 translin-associated factor X interacting protein 1 -2.15255
ADAM20 ADAM metallopeptidase domain 20 -2.15045
TRMT9B tRNA methyltransferase 9B (putative) -2.13395
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus -2.1327
CCDC186 coiled-coil domain containing 186 -2.12985
STX11 syntaxin 11 -2.12095
YPEL5 yippee-like 5 (Drosophila) -2.113
STX7 syntaxin 7 -2.11242
RBBP9 retinoblastoma binding protein 9 -2.11185
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -2.10065
TGFBR1 transforming growth factor, beta receptor 1 -2.10005
TRAFD1 TRAF-type zinc finger domain containing 1 -2.09435
ARHGAP24 Rho GTPase activating protein 24 -2.091
MKS1 Meckel syndrome, type 1 -2.0888
KLK15 kallikrein-related peptidase 15 -2.0843
TP53 tumor protein p53 -2.08385
TMEM120B transmembrane protein 120B -2.08355
SCHIP1 schwannomin interacting protein 1 -2.08065
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -2.07715
RAG1 recombination activating gene 1 -2.07445
SLC35F5 solute carrier family 35, member F5 -2.0729
ZNF778 zinc finger protein 778 -2.06335
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -2.05993
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 -2.0579
FAM76A family with sequence similarity 76, member A -2.05435
INPP5B inositol polyphosphate-5-phosphatase, 75kDa -2.053
HTN3 histatin 3 -2.0498
CLCN6 chloride channel, voltage-sensitive 6 -2.04945
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled -2.0443
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.0422
ADPRH ADP-ribosylarginine hydrolase -2.0361
CLDN9 claudin 9 -2.0352
MSMB microseminoprotein, beta- -2.03355
RIMS1 regulating synaptic membrane exocytosis 1 -2.0292
HTN1 histatin 1 -2.0284
CCN5 cellular communication network factor 5 -2.02075
GP9 glycoprotein IX (platelet) -2.0204
ARMCX4 armadillo repeat containing, X-linked 4 -2.0197
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -2.01405
EP400 E1A binding protein p400 -2.01273
SP4 Sp4 transcription factor -2.01085
RARS1 arginyl-tRNA synthetase 1 -2.00725
CRYGB crystallin, gamma B -2.0068
ARHGAP5 Rho GTPase activating protein 5 -2.00545
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -2.0024