CRCGN015_MCF10A.TP53.M_24H:A12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (e)-3h-indol-3-ylidenemethanol 11.32 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

89 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:A12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 5.70255
PPARG peroxisome proliferator-activated receptor gamma 5.46155
CNRIP1 cannabinoid receptor interacting protein 1 4.8088
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.72755
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 4.65845
GATA3 GATA binding protein 3 4.5252
GADD45A growth arrest and DNA-damage-inducible, alpha 3.3663
PDLIM1 PDZ and LIM domain 1 3.0852
MCUR1 mitochondrial calcium uniporter regulator 1 2.8971
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.71785
ZBTB35 zinc finger and BTB domain containing 35 2.69333
PIERCE1 piercer of microtubule wall 1 2.60738
SKA1 spindle and kinetochore associated complex subunit 1 2.455
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 2.4364
RAB1B RAB1B, member RAS oncogene family 2.2347
RPGR retinitis pigmentosa GTPase regulator 2.2195
LZTFL1 leucine zipper transcription factor-like 1 2.19805
QARS1 glutaminyl-tRNA synthetase 1 2.1808
SYNJ2BP synaptojanin 2 binding protein 2.172
DENND2D DENN/MADD domain containing 2D 2.16555
PTGES prostaglandin E synthase 2.15488
IGFALS insulin-like growth factor binding protein, acid labile subunit 2.1447
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 2.1436
SPC25 SPC25, NDC80 kinetochore complex component 2.10065
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 2.0971
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.0961
WIF1 WNT inhibitory factor 1 2.089
COPS7A COP9 signalosome subunit 7A 2.078
TPGS1 tubulin polyglutamylase complex subunit 1 2.0748
DNAAF11 dynein axonemal assembly factor 11 2.03605
TBC1D10C TBC1 domain family, member 10C 2.00985
APOO apolipoprotein O 2.0016

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.1245
SLC35F2 solute carrier family 35, member F2 -4.91775
PCNA proliferating cell nuclear antigen -4.66275
CDC20 cell division cycle 20 -4.66275
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -4.5982
HMG20B high mobility group 20B -4.28328
GRN granulin -3.4315
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -2.61255
TRIB3 tribbles pseudokinase 3 -2.5639
AHSP alpha hemoglobin stabilizing protein -2.5391
MORC2 MORC family CW-type zinc finger 2 -2.50185
BSG basigin (Ok blood group) -2.4483
TRAF1 TNF receptor-associated factor 1 -2.414
IL5 interleukin 5 -2.3967
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -2.38755
HBD hemoglobin, delta -2.3765
CCDC68 coiled-coil domain containing 68 -2.35865
TMEM230 transmembrane protein 230 -2.35355
ELOVL1 ELOVL fatty acid elongase 1 -2.33433
ZNF665 zinc finger protein 665 -2.3341
MAVS mitochondrial antiviral signaling protein -2.3259
GDF7 growth differentiation factor 7 -2.294
VRK2 vaccinia related kinase 2 -2.26425
PANK2 pantothenate kinase 2 -2.25565
DAZL deleted in azoospermia-like -2.2468
CDIP1 cell death-inducing p53 target 1 -2.2455
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.19975
NR4A2 nuclear receptor subfamily 4, group A, member 2 -2.16783
UROD uroporphyrinogen decarboxylase -2.15073
SZT2 seizure threshold 2 homolog (mouse) -2.14355
VEZT vezatin, adherens junctions transmembrane protein -2.134
GPR65 G protein-coupled receptor 65 -2.1337
PCDHGA10 protocadherin gamma subfamily A, 10 -2.1289
ATP8B4 ATPase, class I, type 8B, member 4 -2.1273
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.1266
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -2.1109
ZNF141 zinc finger protein 141 -2.11005
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough -2.1091
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.10585
CD86 CD86 molecule -2.09935
INF2 inverted formin, FH2 and WH2 domain containing -2.09545
SCRN1 secernin 1 -2.09295
ZNF701 zinc finger protein 701 -2.09275
F2RL2 coagulation factor II (thrombin) receptor-like 2 -2.08825
SENP7 SUMO1/sentrin specific peptidase 7 -2.0857
RABGGTA Rab geranylgeranyltransferase, alpha subunit -2.06665
SLC30A4 solute carrier family 30 (zinc transporter), member 4 -2.06025
CTBS chitobiase, di-N-acetyl- -2.05612
CORO1A coronin, actin binding protein, 1A -2.05425
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 -2.05385
FICD FIC domain containing -2.05055
TREM1 triggering receptor expressed on myeloid cells 1 -2.05025
SMCO4 single-pass membrane protein with coiled-coil domains 4 -2.04495
NABP1 nucleic acid binding protein 1 -2.03755
ADA2 adenosine deaminase 2 -2.0303
PCDHGA3 protocadherin gamma subfamily A, 3 -2.0078
OVOL2 ovo-like zinc finger 2 -2.00775