CRCGN015_MCF10A.TP53.M_24H:A13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 96.45 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:A13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 7.7999
TXNRD1 thioredoxin reductase 1 6.63055
MAP7 microtubule-associated protein 7 5.15412
ZBTB35 zinc finger and BTB domain containing 35 3.59415
KLHL21 kelch-like family member 21 3.48865
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.8649
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.63705
AGR2 anterior gradient 2 2.60355
KEAP1 kelch-like ECH-associated protein 1 2.5542
NUP155 nucleoporin 155kDa 2.47635
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.3355
NOLC1 nucleolar and coiled-body phosphoprotein 1 2.29515
SQSTM1 sequestosome 1 2.2434
STAMBP STAM binding protein 2.19485
PDLIM1 PDZ and LIM domain 1 2.1849
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.11738
CTSL cathepsin L 2.0774
RPIA ribose 5-phosphate isomerase A 2.07415
AARS1 alanyl-tRNA synthetase 1 2.07325
OXSR1 oxidative stress responsive 1 2.0675
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.02875
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.02795

decreased expression

Symbol Name Standardized Value
HOXA5 homeobox A5 -5.7747
PMM2 phosphomannomutase 2 -5.38165
GRN granulin -4.68485
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.98705
ANKRD10 ankyrin repeat domain 10 -3.23655
FPGS folylpolyglutamate synthase -3.2309
DDB2 damage-specific DNA binding protein 2, 48kDa -2.7583
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.4225
HOXA4 homeobox A4 -2.374
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.34025
CD81 CD81 molecule -2.2985
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.21513
MAN2B2 mannosidase, alpha, class 2B, member 2 -2.21185
PYGL phosphorylase, glycogen, liver -2.2027
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.20055
DYNLT3 dynein, light chain, Tctex-type 3 -2.1587
RPA3 replication protein A3, 14kDa -2.14055
DDIT4 DNA-damage-inducible transcript 4 -2.08105
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) -2.03932