CRCGN015_MCF10A.TP53.M_24H:A14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 32.15 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

93 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:A14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 6.30885
ZNF586 zinc finger protein 586 5.56985
HMOX1 heme oxygenase 1 5.28
ZNF134 zinc finger protein 134 4.44735
ZNF551 zinc finger protein 551 3.93915
MELK maternal embryonic leucine zipper kinase 3.8
IGHMBP2 immunoglobulin mu binding protein 2 3.69185
ZNF211 zinc finger protein 211 3.68925
ZNF304 zinc finger protein 304 3.59505
ACAA1 acetyl-CoA acyltransferase 1 3.53635
ZNF587B zinc finger protein 587B 3.43595
ZNF419 zinc finger protein 419 3.40248
LYRM1 LYR motif containing 1 3.23885
TBPL1 TBP-like 1 3.18735
CNRIP1 cannabinoid receptor interacting protein 1 3.1617
ZNF761 zinc finger protein 761 3.1036
ZNF671 zinc finger protein 671 2.92385
ZNF587 zinc finger protein 587 2.8721
SYNGAP1 synaptic Ras GTPase activating protein 1 2.8217
SQSTM1 sequestosome 1 2.6033
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.4992
ADRB2 adrenoceptor beta 2, surface 2.48195
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 2.4507
AQP6 aquaporin 6, kidney specific 2.34998
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.3391
RPIA ribose 5-phosphate isomerase A 2.3243
XPOT exportin, tRNA 2.3189
AURKC aurora kinase C 2.3128
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 2.30638
BIRC2 baculoviral IAP repeat containing 2 2.2847
ALG3 ALG3, alpha-1,3- mannosyltransferase 2.2837
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 2.27565
TMEM208 transmembrane protein 208 2.25755
LOC128125814 uncharacterized LOC128125814 2.22765
TOMM34 translocase of outer mitochondrial membrane 34 2.22245
ODR4 odr-4 GPCR localization factor homolog 2.20335
COQ8A coenzyme Q8A 2.1576
ZNF562 zinc finger protein 562 2.15575
NRBF2 nuclear receptor binding factor 2 2.1369
RBM28 RNA binding motif protein 28 2.1347
RBBP8 retinoblastoma binding protein 8 2.11785
AGR2 anterior gradient 2 2.11755
ZNF8 zinc finger protein 8 2.1114
SPOUT1 SPOUT domain containing methyltransferase 1 2.1085
GOLGA7 golgin A7 2.0992
CDC73 cell division cycle 73 2.0952
CNOT7 CCR4-NOT transcription complex, subunit 7 2.0909
TEX10 testis expressed 10 2.0803
EMC7 ER membrane protein complex subunit 7 2.0763
TP53BP1 tumor protein p53 binding protein 1 2.07275
MFAP1 microfibrillar-associated protein 1 2.05825
EDC4 enhancer of mRNA decapping 4 2.0342
BAG4 BCL2-associated athanogene 4 2.0302
TICAM1 toll-like receptor adaptor molecule 1 2.0278
ZNF544 zinc finger protein 544 2.0047

decreased expression

Symbol Name Standardized Value
TCTA T-cell leukemia translocation altered -5.7178
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.45785
CCNB1 cyclin B1 -5.04835
ANXA2 annexin A2 -4.93545
HSPA8 heat shock 70kDa protein 8 -4.91505
HMG20B high mobility group 20B -4.85812
TUBB6 tubulin, beta 6 class V -4.57735
BPHL biphenyl hydrolase-like (serine hydrolase) -3.5696
DDIT4 DNA-damage-inducible transcript 4 -3.24315
BASP1 brain abundant, membrane attached signal protein 1 -3.19215
KDM3A lysine (K)-specific demethylase 3A -3.01305
NAGA N-acetylgalactosaminidase, alpha- -2.8165
MTMR14 myotubularin related protein 14 -2.73015
GRN granulin -2.66157
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.65773
ANKRD10 ankyrin repeat domain 10 -2.5309
DDB2 damage-specific DNA binding protein 2, 48kDa -2.51755
IRF8 interferon regulatory factor 8 -2.4569
PRSS23 protease, serine, 23 -2.36315
CORO1A coronin, actin binding protein, 1A -2.3228
CD81 CD81 molecule -2.3184
RNF130 ring finger protein 130 -2.29195
MAPK1 mitogen-activated protein kinase 1 -2.24705
HOXA5 homeobox A5 -2.2048
SPON2 spondin 2, extracellular matrix protein -2.1828
CCL5 chemokine (C-C motif) ligand 5 -2.17177
CENPA centromere protein A -2.13702
MYO16 myosin XVI -2.1329
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -2.11268
TUBB2A tubulin, beta 2A class IIa -2.11084
ATP11B ATPase, class VI, type 11B -2.0974
BLVRB biliverdin reductase B -2.0873
DGCR6L DiGeorge syndrome critical region gene 6-like -2.0826
RBX1 ring-box 1, E3 ubiquitin protein ligase -2.03505
CAB39 calcium binding protein 39 -2.0339
LNPEP leucyl/cystinyl aminopeptidase -2.0084
CD9 CD9 molecule -2.00255
RAP2A RAP2A, member of RAS oncogene family -2.00055