CRCGN015_MCF10A.TP53.M_24H:A15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 10.72 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

106 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:A15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 5.42015
GPER1 G protein-coupled estrogen receptor 1 5.24975
MEF2C myocyte enhancer factor 2C 5.20602
C2CD2 C2 calcium-dependent domain containing 2 5.19
CARMIL1 capping protein regulator and myosin 1 linker 1 5.0
ADAM10 ADAM metallopeptidase domain 10 4.99125
IDE insulin-degrading enzyme 4.61712
WIF1 WNT inhibitory factor 1 3.71115
HBB hemoglobin, beta 3.53643
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 3.49215
PRKCH protein kinase C, eta 3.45473
CCDC85B coiled-coil domain containing 85B 3.31775
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.12961
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.9671
MMP1 matrix metallopeptidase 1 2.93673
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.91185
TXNRD1 thioredoxin reductase 1 2.7948
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.7754
MMRN1 multimerin 1 2.7578
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.75385
LGMN legumain 2.6518
AK5 adenylate kinase 5 2.6377
BAX BCL2-associated X protein 2.62565
MANEA mannosidase, endo-alpha 2.56895
CYBA cytochrome b-245, alpha polypeptide 2.54985
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.5075
CALCRL calcitonin receptor-like 2.49907
DAND5 DAN domain family member 5, BMP antagonist 2.4862
PARVB parvin, beta 2.48019
TESPA1 thymocyte expressed, positive selection associated 1 2.47115
HIPK3 homeodomain interacting protein kinase 3 2.46677
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.4384
SENP7 SUMO1/sentrin specific peptidase 7 2.4243
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 2.4026
LIM2 lens intrinsic membrane protein 2, 19kDa 2.39155
RHOH ras homolog family member H 2.3791
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.35705
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2.33525
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 2.31935
GNA13 guanine nucleotide binding protein (G protein), alpha 13 2.28865
MINDY2 MINDY lysine 48 deubiquitinase 2 2.28822
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.26355
KIF5A kinesin family member 5A 2.26035
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 2.25758
ATP4B ATPase, H+/K+ exchanging, beta polypeptide 2.2491
ICAM2 intercellular adhesion molecule 2 2.24705
VNN1 vanin 1 2.23655
CBLIF cobalamin binding intrinsic factor 2.2339
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 2.224
GPATCH8 G patch domain containing 8 2.21958
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2.21435
TGFBR1 transforming growth factor, beta receptor 1 2.20745
GJA4 gap junction protein, alpha 4, 37kDa 2.20103
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 2.17882
KLK11 kallikrein-related peptidase 11 2.17465
RASIP1 Ras interacting protein 1 2.17055
ADPRH ADP-ribosylarginine hydrolase 2.16395
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.1549
TBPL1 TBP-like 1 2.14375
LIPF lipase, gastric 2.14275
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 2.12673
PECAM1 platelet/endothelial cell adhesion molecule 1 2.11212
RUNX2 runt-related transcription factor 2 2.1114
ALAS1 5'-aminolevulinate synthase 1 2.09255
KCTD20 potassium channel tetramerization domain containing 20 2.0767
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 2.07395
BAK1 BCL2-antagonist/killer 1 2.0479
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.04667
LIMD1 LIM domains containing 1 2.0454
ZNF747 zinc finger protein 747 2.04455
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 2.04058
VWF von Willebrand factor 2.02385
JUND jun D proto-oncogene 2.01053

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.3421
TCTA T-cell leukemia translocation altered -5.02575
DIPK1A divergent protein kinase domain 1A -4.62512
PCCB propionyl CoA carboxylase, beta polypeptide -3.978
PTK2 protein tyrosine kinase 2 -3.97552
BLCAP bladder cancer associated protein -3.3276
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.10395
ANKRD10 ankyrin repeat domain 10 -2.8691
PFN2 profilin 2 -2.8124
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.73455
PRCP prolylcarboxypeptidase (angiotensinase C) -2.7061
CD81 CD81 molecule -2.68365
RGS2 regulator of G-protein signaling 2 -2.593
OAT ornithine aminotransferase -2.54755
KRT5 keratin 5, type II -2.30045
VMP1 vacuole membrane protein 1 -2.289
ATP10D ATPase, class V, type 10D -2.2877
DDIT4 DNA-damage-inducible transcript 4 -2.2841
PIH1D1 PIH1 domain containing 1 -2.27465
HACD2 3-hydroxyacyl-CoA dehydratase 2 -2.27345
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) -2.19205
SGK1 serum/glucocorticoid regulated kinase 1 -2.1785
GMPR2 guanosine monophosphate reductase 2 -2.14825
GRN granulin -2.12805
DHRS1 dehydrogenase/reductase (SDR family) member 1 -2.1236
SGCE sarcoglycan, epsilon -2.1218
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.1135
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.10835
MAEA macrophage erythroblast attacher -2.09985
RHCG Rh family, C glycoprotein -2.0713
TCL1A T-cell leukemia/lymphoma 1A -2.06558
WDR5B WD repeat domain 5B -2.04615
S100A14 S100 calcium binding protein A14 -2.0356