CRCGN015_MCF10A.TP53.M_24H:A17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description shahrm perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:A17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ANO10 anoctamin 10 10.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 9.3397
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.5661
HEBP1 heme binding protein 1 3.5589
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 3.0964
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.0482
STAMBP STAM binding protein 2.9969
CCDC85B coiled-coil domain containing 85B 2.9466
PFAS phosphoribosylformylglycinamidine synthase 2.6513
LOC122526780 uncharacterized LOC122526780 2.628
TOMM34 translocase of outer mitochondrial membrane 34 2.572
PLS1 plastin 1 2.5363
RBM6 RNA binding motif protein 6 2.3853
HOXA5 homeobox A5 2.3571
ACTMAP actin maturation protease 2.3289
NANOS3 nanos homolog 3 (Drosophila) 2.3209
USP6NL USP6 N-terminal like 2.3168
CDC45 cell division cycle 45 2.2885
MRPL19 mitochondrial ribosomal protein L19 2.2881
MMRN1 multimerin 1 2.2801
ARL2 ADP-ribosylation factor-like 2 2.2401
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.2259
CCDC25 coiled-coil domain containing 25 2.2148
SCRIB scribbled planar cell polarity protein 2.1994
WRN Werner syndrome, RecQ helicase-like 2.1855
COQ8A coenzyme Q8A 2.1528
INTS9 integrator complex subunit 9 2.0394
PDIA2 protein disulfide isomerase family A, member 2 2.0288
ZNF334 zinc finger protein 334 2.0259
CLCC1 chloride channel CLIC-like 1 2.0121

decreased expression

Symbol Name Standardized Value
ANKRD10 ankyrin repeat domain 10 -5.8301
FPGS folylpolyglutamate synthase -5.3335
CD81 CD81 molecule -3.8294
RPS5 ribosomal protein S5 -3.5705
MPC2 mitochondrial pyruvate carrier 2 -3.5063
MYLK myosin light chain kinase -2.9482
FBXO7 F-box protein 7 -2.8924
S100A4 S100 calcium binding protein A4 -2.854
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.7791
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.7089
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.5177
MCF2L MCF.2 cell line derived transforming sequence-like -2.4844
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma -2.4586
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.4148
METRN meteorin, glial cell differentiation regulator -2.4005
SIAH2 siah E3 ubiquitin protein ligase 2 -2.2709
RBM7 RNA binding motif protein 7 -2.241
TPD52L2 tumor protein D52-like 2 -2.225
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) -2.2175
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.2127
SEC61G Sec61 gamma subunit -2.2009
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.1726
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -2.1693
CCND3 cyclin D3 -2.1601
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -2.1553
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.1528
ZPR1 ZPR1 zinc finger -2.1468
MVD mevalonate (diphospho) decarboxylase -2.1301
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like -2.1244
FOSL2 FOS-like antigen 2 -2.10613
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.1001
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) -2.089
KLF2 Kruppel-like factor 2 -2.0768
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.062
TMEM265 transmembrane protein 265 -2.0596
TNIP1 TNFAIP3 interacting protein 1 -2.0539
ITCH itchy E3 ubiquitin protein ligase -2.05283
PRSS23 protease, serine, 23 -2.0512
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.0475
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) -2.0406
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 -2.0391
ERH enhancer of rudimentary homolog (Drosophila) -2.0345
IL24 interleukin 24 -2.0324
CLTC clathrin, heavy chain (Hc) -2.0201
AFF4 AF4/FMR2 family, member 4 -2.0185
CNPY3 canopy FGF signaling regulator 3 -2.0177
TXNDC9 thioredoxin domain containing 9 -2.00965
TGFBR1 transforming growth factor, beta receptor 1 -2.0049