CRCGN015_MCF10A.TP53.M_24H:A19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-[4-(5-nitro-2-furyl)-2-thiazo?lyl]formamide 98.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:A19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 5.40475
ZBTB35 zinc finger and BTB domain containing 35 3.82372
CNRIP1 cannabinoid receptor interacting protein 1 3.4011
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 3.1458
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.0689
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.9124
TRAM2 translocation associated membrane protein 2 2.61398
CORO1A coronin, actin binding protein, 1A 2.5901
FCHO1 FCH domain only 1 2.52615
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.3935
RBM7 RNA binding motif protein 7 2.19185
TGFB3 transforming growth factor, beta 3 2.15665
CEP192 centrosomal protein 192kDa 2.14985
CCNA1 cyclin A1 2.1498
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 2.13975
SNX7 sorting nexin 7 2.13495
CEP57 centrosomal protein 57kDa 2.1205
ADRB2 adrenoceptor beta 2, surface 2.1026
ECHDC3 enoyl CoA hydratase domain containing 3 2.0287

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -5.58055
TRAPPC3 trafficking protein particle complex 3 -5.11975
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.0452
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -4.78798
CCNB1 cyclin B1 -4.70195
GRWD1 glutamate-rich WD repeat containing 1 -3.30085
FPGS folylpolyglutamate synthase -3.2456
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.1258
ANKRD10 ankyrin repeat domain 10 -3.1075
BASP1 brain abundant, membrane attached signal protein 1 -2.7364
CDKN2A cyclin-dependent kinase inhibitor 2A -2.54868
SGK1 serum/glucocorticoid regulated kinase 1 -2.43855
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.35278
MRPS15 mitochondrial ribosomal protein S15 -2.3141
ILK integrin-linked kinase -2.28355
AGO1 argonaute RISC catalytic component 1 -2.23365
CXCL5 chemokine (C-X-C motif) ligand 5 -2.21693
ERBIN erbb2 interacting protein -2.1364
ZYX zyxin -2.08015
MAP7D1 MAP7 domain containing 1 -2.0406