CRCGN015_MCF10A.TP53.M_24H:A20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-[4-(5-nitro-2-furyl)-2-thiazo?lyl]formamide 32.78 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

76 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:A20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 5.35765
LAGE3 L antigen family, member 3 5.30195
SSBP2 single-stranded DNA binding protein 2 5.28615
CARMIL1 capping protein regulator and myosin 1 linker 1 5.02795
FGFR4 fibroblast growth factor receptor 4 4.63225
ALAS1 5'-aminolevulinate synthase 1 4.6236
PRKCH protein kinase C, eta 4.37733
MEF2C myocyte enhancer factor 2C 4.25658
MCOLN1 mucolipin 1 4.1507
ACAA1 acetyl-CoA acyltransferase 1 3.41215
TIAM1 T-cell lymphoma invasion and metastasis 1 3.32835
GET1 guided entry of tail-anchored proteins factor 1 2.848
FAR2 fatty acyl CoA reductase 2 2.81655
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.79245
ADRB2 adrenoceptor beta 2, surface 2.76395
HBB hemoglobin, beta 2.51562
MRC1 mannose receptor, C type 1 2.491
PECR peroxisomal trans-2-enoyl-CoA reductase 2.478
NOSIP nitric oxide synthase interacting protein 2.42255
PXMP2 peroxisomal membrane protein 2, 22kDa 2.42112
ELP5 elongator acetyltransferase complex subunit 5 2.39005
ANGPT1 angiopoietin 1 2.32743
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 2.2468
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.2427
MMP1 matrix metallopeptidase 1 2.24228
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.22548
COMP cartilage oligomeric matrix protein 2.2184
ERVMER34-1 endogenous retrovirus group MER34, member 1 2.21625
LACTB2 lactamase, beta 2 2.2157
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 2.21195
MELK maternal embryonic leucine zipper kinase 2.14315
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 2.1127
ZNF557 zinc finger protein 557 2.11155
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.10545
MRPL19 mitochondrial ribosomal protein L19 2.08675
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.08055
CCL13 chemokine (C-C motif) ligand 13 2.07915
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 2.06825
HPSE heparanase 2.0644
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 2.06267
CERT1 ceramide transporter 1 2.05025
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 2.04913
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 2.0347
TMOD1 tropomodulin 1 2.0106

decreased expression

Symbol Name Standardized Value
BASP1 brain abundant, membrane attached signal protein 1 -6.18495
HMG20B high mobility group 20B -5.20778
KIF14 kinesin family member 14 -5.0984
PCNA proliferating cell nuclear antigen -4.66275
UFM1 ubiquitin-fold modifier 1 -4.56175
STXBP2 syntaxin binding protein 2 -3.7124
GRWD1 glutamate-rich WD repeat containing 1 -3.03255
SLC39A6 solute carrier family 39 (zinc transporter), member 6 -2.93453
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.70825
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -2.5955
DENND4C DENN/MADD domain containing 4C -2.5881
BPHL biphenyl hydrolase-like (serine hydrolase) -2.46705
TLK2 tousled-like kinase 2 -2.31993
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.31547
FMNL3 formin-like 3 -2.3014
SGK1 serum/glucocorticoid regulated kinase 1 -2.2903
CORO1A coronin, actin binding protein, 1A -2.21015
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.20365
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.20155
UBA5 ubiquitin-like modifier activating enzyme 5 -2.1872
RBBP8 retinoblastoma binding protein 8 -2.16115
RASA2 RAS p21 protein activator 2 -2.12795
POLI polymerase (DNA directed) iota -2.10455
MFSD12 major facilitator superfamily domain containing 12 -2.0978
ZNF516 zinc finger protein 516 -2.0836
ANKRD36C ankyrin repeat domain 36C -2.0787
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.06467
COTL1 coactosin-like F-actin binding protein 1 -2.0492
VAC14 Vac14 homolog (S. cerevisiae) -2.0484
RETN resistin -2.03205
RHOBTB1 Rho-related BTB domain containing 1 -2.0253
IER2 immediate early response 2 -2.0044