CRCGN015_MCF10A.TP53.M_24H:A21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-[4-(5-nitro-2-furyl)-2-thiazo?lyl]formamide 10.93 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

162 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:A21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PEX11A peroxisomal biogenesis factor 11 alpha 5.56087
CASP2 caspase 2, apoptosis-related cysteine peptidase 5.37861
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.3658
KIF5C kinesin family member 5C 5.22678
CCP110 centriolar coiled coil protein 110kDa 5.21865
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.1528
CCL2 chemokine (C-C motif) ligand 2 4.4715
KDM5A lysine (K)-specific demethylase 5A 4.24535
TBX2 T-box 2 4.08592
MTA2 metastasis associated 1 family, member 2 3.628
ACAA1 acetyl-CoA acyltransferase 1 3.56647
PDGFA platelet-derived growth factor alpha polypeptide 3.50002
MICALL1 MICAL-like 1 3.45913
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.18895
TUBA3E tubulin, alpha 3e 3.08575
CEPT1 choline/ethanolamine phosphotransferase 1 3.0757
RBBP5 retinoblastoma binding protein 5 2.99555
DDRGK1 DDRGK domain containing 1 2.93605
ZNF197 zinc finger protein 197 2.9208
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 2.72785
SATB1 SATB homeobox 1 2.68545
ETV6 ets variant 6 2.6726
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 2.66245
STRN3 striatin, calmodulin binding protein 3 2.6593
NUTF2 nuclear transport factor 2 2.63075
THRAP3 thyroid hormone receptor associated protein 3 2.63065
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.62935
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.62908
IFI6 interferon, alpha-inducible protein 6 2.62475
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.61827
INCENP inner centromere protein antigens 135/155kDa 2.6145
PGPEP1 pyroglutamyl-peptidase I 2.59665
ADRB2 adrenoceptor beta 2, surface 2.58885
ZNF35 zinc finger protein 35 2.5682
CHEK2 checkpoint kinase 2 2.56028
ATP13A1 ATPase type 13A1 2.5299
FSD1 fibronectin type III and SPRY domain containing 1 2.5149
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.5143
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 2.4964
ETNK1 ethanolamine kinase 1 2.46002
MCMBP minichromosome maintenance complex binding protein 2.44245
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 2.4391
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.4348
GCAT glycine C-acetyltransferase 2.42915
MDM4 MDM4, p53 regulator 2.3992
VWA1 von Willebrand factor A domain containing 1 2.3737
NTSR1 neurotensin receptor 1 (high affinity) 2.357
SRSF6 serine/arginine-rich splicing factor 6 2.35507
TASL TLR adaptor interacting with endolysosomal SLC15A4 2.32985
CD180 CD180 molecule 2.31985
NACAD NAC alpha domain containing 2.30375
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 2.28969
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 2.2895
TRIB3 tribbles pseudokinase 3 2.286
LYRM1 LYR motif containing 1 2.28535
ZCCHC2 zinc finger, CCHC domain containing 2 2.23875
KIAA0930 KIAA0930 2.23583
CCNE2 cyclin E2 2.22598
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 2.21993
STMN4 stathmin-like 4 2.2188
PANK2 pantothenate kinase 2 2.2182
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 2.2144
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 2.20952
TSPAN8 tetraspanin 8 2.2087
ZSCAN16 zinc finger and SCAN domain containing 16 2.20775
ZNF692 zinc finger protein 692 2.2021
ZNHIT2 zinc finger, HIT-type containing 2 2.20165
SEPHS2 selenophosphate synthetase 2 2.19905
FAM13B family with sequence similarity 13, member B 2.18135
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.1792
PRM2 protamine 2 2.1789
PRPF39 pre-mRNA processing factor 39 2.16505
DEFB1 defensin, beta 1 2.1597
SAA2 serum amyloid A2 2.15258
ZNF93 zinc finger protein 93 2.1508
TRIM66 tripartite motif containing 66 2.14795
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 2.1474
NUDC nudC nuclear distribution protein 2.14178
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.13743
DEPDC5 DEP domain containing 5 2.1355
FNBP1L formin binding protein 1-like 2.1344
ZNF180 zinc finger protein 180 2.13045
SAA4 serum amyloid A4, constitutive 2.12295
CENPB centromere protein B, 80kDa 2.1227
MAGEB2 melanoma antigen family B2 2.1213
ZNF239 zinc finger protein 239 2.1099
NCK2 NCK adaptor protein 2 2.10155
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 2.09885
TWNK twinkle mtDNA helicase 2.0916
TMEM121 transmembrane protein 121 2.08945
TMEM51 transmembrane protein 51 2.08835
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa 2.08768
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 2.081
LBP lipopolysaccharide binding protein 2.06227
RAD54L RAD54-like (S. cerevisiae) 2.0609
SOX12 SRY (sex determining region Y)-box 12 2.054
RANGAP1 Ran GTPase activating protein 1 2.04653
GSTT1 glutathione S-transferase theta 1 2.04155
ZBTB35 zinc finger and BTB domain containing 35 2.0375
ZFPM1 zinc finger protein, FOG family member 1 2.03745
ZNF112 zinc finger protein 112 2.022
LRP5 low density lipoprotein receptor-related protein 5 2.0199
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 2.00815
NME5 NME/NM23 family member 5 2.00485
GSTM3 glutathione S-transferase mu 3 (brain) 2.00445
TUBA3C tubulin, alpha 3c 2.00345
RABIF RAB interacting factor 2.0016

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -10.0
CCNB1 cyclin B1 -5.39775
ADI1 acireductone dioxygenase 1 -5.36795
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.22765
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -4.59093
BASP1 brain abundant, membrane attached signal protein 1 -4.38965
PTK2 protein tyrosine kinase 2 -4.36785
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -4.2348
LYPLA1 lysophospholipase I -4.15497
EXOSC8 exosome component 8 -4.0599
MTRF1 mitochondrial translational release factor 1 -3.3205
GADD45B growth arrest and DNA-damage-inducible, beta -3.06833
PSIP1 PC4 and SFRS1 interacting protein 1 -3.05205
ESD esterase D -2.93435
MTERF3 mitochondrial transcription termination factor 3 -2.91815
MRPS31 mitochondrial ribosomal protein S31 -2.84225
PROSER1 proline and serine rich 1 -2.7785
NELL1 NEL-like 1 (chicken) -2.75815
ATL2 atlastin GTPase 2 -2.7059
MOCS2 molybdenum cofactor synthesis 2 -2.67165
RBMX RNA binding motif protein, X-linked -2.59165
NCKAP1 NCK-associated protein 1 -2.45295
PHF11 PHD finger protein 11 -2.43635
DLAT dihydrolipoamide S-acetyltransferase -2.39727
KPNA3 karyopherin alpha 3 (importin alpha 4) -2.39077
STX1A syntaxin 1A (brain) -2.3755
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 -2.3596
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.3516
GRWD1 glutamate-rich WD repeat containing 1 -2.27395
FCN1 ficolin (collagen/fibrinogen domain containing) 1 -2.2548
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -2.25042
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) -2.24705
TESPA1 thymocyte expressed, positive selection associated 1 -2.23075
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.2297
RFC3 replication factor C (activator 1) 3, 38kDa -2.212
ITM2C integral membrane protein 2C -2.20865
RASA4B RAS p21 protein activator 4B -2.19845
RHOH ras homolog family member H -2.19765
GSTO1 glutathione S-transferase omega 1 -2.17935
RNF103-CHMP3 RNF103-CHMP3 readthrough -2.1752
DENND4C DENN/MADD domain containing 4C -2.17155
FNDC3A fibronectin type III domain containing 3A -2.17115
DCTD dCMP deaminase -2.14348
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -2.1403
ATRAID all-trans retinoic acid-induced differentiation factor -2.1236
PARP4 poly (ADP-ribose) polymerase family, member 4 -2.10895
SIDT1 SID1 transmembrane family, member 1 -2.10675
ADCY7 adenylate cyclase 7 -2.1058
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -2.08497
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) -2.07545
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.0736
TSC22D1 TSC22 domain family, member 1 -2.07255
GTF3A general transcription factor IIIA -2.06075
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -2.0286
SKIC3 SKI3 subunit of superkiller complex -2.02215