CRCGN015_MCF10A.TP53.M_24H:A22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (4-chloro-2-methylphenoxy)acetic acid 106.59 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

134 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:A22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
COMP cartilage oligomeric matrix protein 5.0
LAGE3 L antigen family, member 3 4.9504
MCOLN1 mucolipin 1 4.9137
MELK maternal embryonic leucine zipper kinase 3.96285
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.25005
TBPL1 TBP-like 1 3.19865
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 3.16253
CCDC85B coiled-coil domain containing 85B 3.04805
PDE2A phosphodiesterase 2A, cGMP-stimulated 2.8988
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.86685
FCHO1 FCH domain only 1 2.76205
PNPLA6 patatin-like phospholipase domain containing 6 2.75975
CNRIP1 cannabinoid receptor interacting protein 1 2.7165
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 2.5029
APTX aprataxin 2.48615
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.46513
UCKL1 uridine-cytidine kinase 1-like 1 2.46085
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 2.44825
COPS5 COP9 signalosome subunit 5 2.43365
FMO3 flavin containing monooxygenase 3 2.37357
TPD52L2 tumor protein D52-like 2 2.32575
CERS2 ceramide synthase 2 2.32285
STEEP1 STING1 ER exit protein 1 2.30115
CYCS cytochrome c, somatic 2.25925
PRMT3 protein arginine methyltransferase 3 2.25715
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.2458
LMBR1L limb development membrane protein 1-like 2.23495
PMVK phosphomevalonate kinase 2.2284
SLC35F5 solute carrier family 35, member F5 2.21805
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase 2.20605
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa 2.1806
SLC68A1 solute carrier family 68 member 1 2.16655
INTS9 integrator complex subunit 9 2.1336
SDCBP syndecan binding protein (syntenin) 2.1299
MYBBP1A MYB binding protein (P160) 1a 2.11885
CHEK1 checkpoint kinase 1 2.11212
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 2.0824
MEOX1 mesenchyme homeobox 1 2.0568
GPR183 G protein-coupled receptor 183 2.0318
PENK proenkephalin 2.02605
PEX13 peroxisomal biogenesis factor 13 2.0217
UNG uracil-DNA glycosylase 2.0154
MTX1 metaxin 1 2.0091
CD5L CD5 molecule-like 2.00475

decreased expression

Symbol Name Standardized Value
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -5.14885
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.0712
ANXA2 annexin A2 -4.92013
FASTKD5 FAST kinase domains 5 -4.27255
PPIC peptidylprolyl isomerase C (cyclophilin C) -3.91197
KDM3A lysine (K)-specific demethylase 3A -3.72455
RPS5 ribosomal protein S5 -3.43385
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.35936
BASP1 brain abundant, membrane attached signal protein 1 -3.32
SNCA synuclein, alpha (non A4 component of amyloid precursor) -3.24461
TCEA2 transcription elongation factor A (SII), 2 -3.09595
RFC2 replication factor C (activator 1) 2, 40kDa -3.08945
TCTA T-cell leukemia translocation altered -3.01035
MYL11 myosin light chain 11 -2.90505
MYBPC2 myosin binding protein C, fast type -2.81675
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.70105
XKR8 XK, Kell blood group complex subunit-related family, member 8 -2.65555
CAV3 caveolin 3 -2.63935
MTMR14 myotubularin related protein 14 -2.6257
AP1B1 adaptor-related protein complex 1, beta 1 subunit -2.611
CKM creatine kinase, muscle -2.5985
ANKRD10 ankyrin repeat domain 10 -2.5726
TNNI2 troponin I type 2 (skeletal, fast) -2.5715
AURKB aurora kinase B -2.5649
TNNC2 troponin C type 2 (fast) -2.56155
MRPL30 mitochondrial ribosomal protein L30 -2.55705
DNAH3 dynein, axonemal, heavy chain 3 -2.50635
MSRB1 methionine sulfoxide reductase B1 -2.5048
PIH1D1 PIH1 domain containing 1 -2.4443
HRC histidine rich calcium binding protein -2.41765
MYL1 myosin, light chain 1, alkali; skeletal, fast -2.406
ACTA1 actin, alpha 1, skeletal muscle -2.3902
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -2.3874
EYA4 EYA transcriptional coactivator and phosphatase 4 -2.38035
TNNI1 troponin I type 1 (skeletal, slow) -2.3732
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -2.3558
LMF2 lipase maturation factor 2 -2.34522
TUBB4B tubulin, beta 4B class IVb -2.33547
GRWD1 glutamate-rich WD repeat containing 1 -2.3175
TPSG1 tryptase gamma 1 -2.30675
RHOT2 ras homolog family member T2 -2.2976
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal -2.29743
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.29125
DRC4 dynein regulatory complex subunit 4 -2.2852
KRTAP5-2 keratin associated protein 5-2 -2.2834
ARMC7 armadillo repeat containing 7 -2.268
STAC SH3 and cysteine rich domain -2.25505
NEFL neurofilament, light polypeptide -2.24485
ZNF747 zinc finger protein 747 -2.24075
RAB3D RAB3D, member RAS oncogene family -2.23375
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -2.22615
KLHL41 kelch-like family member 41 -2.2245
LCN2 lipocalin 2 -2.22065
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -2.2116
GPC3 glypican 3 -2.20425
CX3CR1 chemokine (C-X3-C motif) receptor 1 -2.20385
INO80D INO80 complex subunit D -2.1933
MYBPH myosin binding protein H -2.19165
DES desmin -2.15632
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 -2.15395
QPCT glutaminyl-peptide cyclotransferase -2.15245
AVPR1B arginine vasopressin receptor 1B -2.1475
REEP1 receptor accessory protein 1 -2.1378
TNNT1 troponin T type 1 (skeletal, slow) -2.1296
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C -2.1275
SMPX small muscle protein, X-linked -2.12625
EFHC1 EF-hand domain (C-terminal) containing 1 -2.1046
ADSL adenylosuccinate lyase -2.09812
MYL4 myosin, light chain 4, alkali; atrial, embryonic -2.09693
GPR31 G protein-coupled receptor 31 -2.0943
MYO1F myosin IF -2.0905
MYOD1 myogenic differentiation 1 -2.08715
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.08535
CASQ2 calsequestrin 2 (cardiac muscle) -2.07925
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -2.07625
IFT46 intraflagellar transport 46 -2.0705
SYT2 synaptotagmin II -2.0692
MYOZ1 myozenin 1 -2.06895
PGM5 phosphoglucomutase 5 -2.06425
GSTCD glutathione S-transferase, C-terminal domain containing -2.0541
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) -2.0478
SNTA1 syntrophin, alpha 1 -2.0469
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 -2.0353
IL17RA interleukin 17 receptor A -2.0328
CD302 CD302 molecule -2.02935
MB myoglobin -2.0293
RNF167 ring finger protein 167 -2.0147
TUG1 taurine up-regulated 1 (non-protein coding) -2.00917
OGFRL1 opioid growth factor receptor-like 1 -2.0045
LGI2 leucine-rich repeat LGI family, member 2 -2.0013