CRCGN015_MCF10A.TP53.M_24H:A24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (4-chloro-2-methylphenoxy)acetic acid 11.84 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

170 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:A24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCR4 chemokine (C-X-C motif) receptor 4 5.57935
ADGRE5 adhesion G protein-coupled receptor E5 5.5736
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.28045
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.218
CHEK1 checkpoint kinase 1 5.12165
STAP2 signal transducing adaptor family member 2 5.0506
CNRIP1 cannabinoid receptor interacting protein 1 5.0
AGR2 anterior gradient 2 5.0
HBA1 hemoglobin, alpha 1 4.19049
DNA2 DNA replication helicase/nuclease 2 3.6267
SPTAN1 spectrin, alpha, non-erythrocytic 1 3.15933
PARPBP PARP1 binding protein 3.1176
IL13RA1 interleukin 13 receptor, alpha 1 2.98435
CENPT centromere protein T 2.885
PLA2G12A phospholipase A2, group XIIA 2.8003
ERBIN erbb2 interacting protein 2.7262
UNC5B unc-5 homolog B (C. elegans) 2.65618
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.6557
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.65015
LOC128031832 uncharacterized LOC128031832 2.59715
PIEZO1 piezo-type mechanosensitive ion channel component 1 2.5786
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.57345
APOLD1 apolipoprotein L domain containing 1 2.5632
SKA1 spindle and kinetochore associated complex subunit 1 2.5159
CETN3 centrin, EF-hand protein, 3 2.4725
C1R complement component 1, r subcomponent 2.4447
S100A4 S100 calcium binding protein A4 2.43605
FBXL12 F-box and leucine-rich repeat protein 12 2.42995
CCNE2 cyclin E2 2.41398
CLDN1 claudin 1 2.4096
EVL Enah/Vasp-like 2.39835
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 2.36435
RAI14 retinoic acid induced 14 2.35405
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.3529
LOC102724428 serine/threonine-protein kinase SIK1 2.3383
HKDC1 hexokinase domain containing 1 2.33335
ITPRID2 ITPR interacting domain containing 2 2.33015
INSIG2 insulin induced gene 2 2.32525
DENND2D DENN/MADD domain containing 2D 2.31815
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.30745
SAC3D1 SAC3 domain containing 1 2.29
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 2.281
IGF2 insulin-like growth factor 2 2.27832
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.24032
DSCC1 DNA replication and sister chromatid cohesion 1 2.2136
PRELID3B PRELI domain containing 3B 2.21315
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 2.20715
RELN reelin 2.2031
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 2.2029
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 2.20105
PVRIG poliovirus receptor related immunoglobulin domain containing 2.19555
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.18935
KMT5A lysine methyltransferase 5A 2.17605
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 2.16245
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.145
KCTD9 potassium channel tetramerization domain containing 9 2.12
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.11725
XAB2 XPA binding protein 2 2.1172
H2AC19 H2A clustered histone 19 2.1063
CREG1 cellular repressor of E1A-stimulated genes 1 2.1024
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 2.08815
MICALL2 MICAL-like 2 2.0795
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.07843
AOPEP aminopeptidase O (putative) 2.0782
PTP4A2 protein tyrosine phosphatase type IVA, member 2 2.07733
RAG1 recombination activating gene 1 2.07185
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 2.0712
KLF5 Kruppel-like factor 5 (intestinal) 2.0542
DVL1 dishevelled segment polarity protein 1 2.04455
CADM1 cell adhesion molecule 1 2.0438
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.04245
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.03545
ARHGAP11A Rho GTPase activating protein 11A 2.03235
TOB1 transducer of ERBB2, 1 2.02645
COMP cartilage oligomeric matrix protein 2.0211
OLFML1 olfactomedin-like 1 2.00175

decreased expression

Symbol Name Standardized Value
COG7 component of oligomeric golgi complex 7 -6.0949
CAB39 calcium binding protein 39 -5.8278
PARP2 poly (ADP-ribose) polymerase 2 -5.72978
BAG3 BCL2-associated athanogene 3 -5.31185
CDC20 cell division cycle 20 -5.0
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.67815
ATP11B ATPase, class VI, type 11B -4.19555
TXNDC9 thioredoxin domain containing 9 -4.01202
SNCA synuclein, alpha (non A4 component of amyloid precursor) -3.87529
MRPL17 mitochondrial ribosomal protein L17 -3.442
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.35582
PPP4C protein phosphatase 4, catalytic subunit -3.08235
GRWD1 glutamate-rich WD repeat containing 1 -3.01975
NLRP4 NLR family, pyrin domain containing 4 -2.95975
LCMT1 leucine carboxyl methyltransferase 1 -2.94615
ACTG2 actin, gamma 2, smooth muscle, enteric -2.9427
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.91915
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -2.80255
BPHL biphenyl hydrolase-like (serine hydrolase) -2.79715
OARD1 O-acyl-ADP-ribose deacylase 1 -2.787
METTL17 methyltransferase like 17 -2.69985
INPP5F inositol polyphosphate-5-phosphatase F -2.65515
PPME1 protein phosphatase methylesterase 1 -2.6437
OSGEP O-sialoglycoprotein endopeptidase -2.60775
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough -2.554
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.55192
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -2.53475
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.5342
PALB2 partner and localizer of BRCA2 -2.5277
RAB3B RAB3B, member RAS oncogene family -2.49552
HEATR1 HEAT repeat containing 1 -2.49498
GMPPB GDP-mannose pyrophosphorylase B -2.4793
DVL2 dishevelled segment polarity protein 2 -2.47465
XYLT1 xylosyltransferase I -2.4671
ALCAM activated leukocyte cell adhesion molecule -2.46615
VPS35L VPS35 endosomal protein sorting factor like -2.46135
VRK1 vaccinia related kinase 1 -2.4319
CA14 carbonic anhydrase XIV -2.41045
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.3907
BBOF1 basal body orientation factor 1 -2.3852
BASP1 brain abundant, membrane attached signal protein 1 -2.3777
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 -2.36265
NUP107 nucleoporin 107kDa -2.34935
HIRIP3 HIRA interacting protein 3 -2.34665
ZNF91 zinc finger protein 91 -2.3378
PRMT5 protein arginine methyltransferase 5 -2.33685
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.30755
ALAS2 5'-aminolevulinate synthase 2 -2.29625
TBCC tubulin folding cofactor C -2.28345
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.28067
CERT1 ceramide transporter 1 -2.2805
TSPAN3 tetraspanin 3 -2.2798
MAP3K10 mitogen-activated protein kinase kinase kinase 10 -2.26165
ZNF764 zinc finger protein 764 -2.26095
TSG101 tumor susceptibility 101 -2.2607
SIGLEC5 sialic acid binding Ig-like lectin 5 -2.23925
DCTN5 dynactin 5 (p25) -2.2327
CRY2 cryptochrome circadian clock 2 -2.2273
MTERF3 mitochondrial transcription termination factor 3 -2.2186
EDA2R ectodysplasin A2 receptor -2.2084
CHPF chondroitin polymerizing factor -2.20245
RGS4 regulator of G-protein signaling 4 -2.20118
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.19925
EFHD1 EF-hand domain family, member D1 -2.1956
TUSC3 tumor suppressor candidate 3 -2.19312
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -2.1923
KAT8 K(lysine) acetyltransferase 8 -2.1855
CALY calcyon neuron-specific vesicular protein -2.1831
CSDC2 cold shock domain containing C2, RNA binding -2.18245
MUC4 mucin 4, cell surface associated -2.17365
LOC128125814 uncharacterized LOC128125814 -2.1556
CD81 CD81 molecule -2.1535
TPBG trophoblast glycoprotein -2.1374
GPHN gephyrin -2.1347
GRN granulin -2.12442
BPIFA1 BPI fold containing family A, member 1 -2.11995
COQ6 coenzyme Q6 monooxygenase -2.1175
ALOX15B arachidonate 15-lipoxygenase, type B -2.11535
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -2.1
SPATA7 spermatogenesis associated 7 -2.0932
CAND2 cullin-associated and neddylation-dissociated 2 (putative) -2.0909
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -2.08495
NPFFR1 neuropeptide FF receptor 1 -2.08385
TEP1 telomerase-associated protein 1 -2.0807
RMC1 regulator of MON1-CCZ1 -2.0761
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A -2.0388
PCDHGA10 protocadherin gamma subfamily A, 10 -2.0314
MT1E metallothionein 1E -2.0305
CCDC81 coiled-coil domain containing 81 -2.02845
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -2.0276
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.02555
SIRAL2 SIR2 antiphage like 2 -2.0182
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) -2.0082
RIMBP2 RIMS binding protein 2 -2.0006