CRCGN015_MCF10A.TP53.M_24H:B04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:B04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
COMP cartilage oligomeric matrix protein 5.56542
MAMLD1 mastermind-like domain containing 1 4.36168
GPATCH8 G patch domain containing 8 3.93486
HBA1 hemoglobin, alpha 1 3.89502
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.57951
FGFR4 fibroblast growth factor receptor 4 3.50647
GARRE1 granule associated Rac and RHOG effector 1 3.17644
GSTZ1 glutathione S-transferase zeta 1 2.83957
EAPP E2F-associated phosphoprotein 2.79255
ATP13A1 ATPase type 13A1 2.74172
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.40619
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 2.39787
ACAA1 acetyl-CoA acyltransferase 1 2.37295
PPARG peroxisome proliferator-activated receptor gamma 2.31265
P3H1 prolyl 3-hydroxylase 1 2.27602
ZMIZ1 zinc finger, MIZ-type containing 1 2.19649
LAMB1 laminin, beta 1 2.18346
WDR46 WD repeat domain 46 2.1514
IFT20 intraflagellar transport 20 2.11398
BIN3 bridging integrator 3 2.10399
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 2.08386
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.06851
INTS9 integrator complex subunit 9 2.05979
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.0538
DENND2D DENN/MADD domain containing 2D 2.04788
SQOR sulfide quinone oxidoreductase 2.01318
EGFL8 EGF-like-domain, multiple 8 2.0025

decreased expression

Symbol Name Standardized Value
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.93493
HSPD1 heat shock 60kDa protein 1 (chaperonin) -4.54561
KRT14 keratin 14, type I -4.35806
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.0326
CD81 CD81 molecule -3.92593
MSMO1 methylsterol monooxygenase 1 -3.62518
RBM34 RNA binding motif protein 34 -3.01887
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.95982
TLK2 tousled-like kinase 2 -2.89958
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.78456
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.58994
PRCP prolylcarboxypeptidase (angiotensinase C) -2.52233
CDK6 cyclin-dependent kinase 6 -2.42359
SOAT2 sterol O-acyltransferase 2 -2.42352
TBCE tubulin folding cofactor E -2.37975
GNPAT glyceronephosphate O-acyltransferase -2.33475
DYNLT1 dynein, light chain, Tctex-type 1 -2.32314
VAT1 vesicle amine transport 1 -2.23281
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.19521
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.18376
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -2.16942
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated -2.14108
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.08334
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.07606
NAE1 NEDD8 activating enzyme E1 subunit 1 -2.04301
KPNA5 karyopherin alpha 5 (importin alpha 6) -2.04057
GGPS1 geranylgeranyl diphosphate synthase 1 -2.03858