CRCGN015_MCF10A.TP53.M_24H:B06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

128 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:B06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 6.63619
CHMP6 charged multivesicular body protein 6 4.70403
E2F2 E2F transcription factor 2 4.59897
CERK ceramide kinase 4.51023
PEX11A peroxisomal biogenesis factor 11 alpha 4.34504
UBQLN2 ubiquilin 2 4.29097
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.26258
COMP cartilage oligomeric matrix protein 4.09696
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.01422
PPARG peroxisome proliferator-activated receptor gamma 3.8001
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.76341
GGT5 gamma-glutamyltransferase 5 3.34786
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.34036
IGHMBP2 immunoglobulin mu binding protein 2 3.11768
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 3.06932
GARRE1 granule associated Rac and RHOG effector 1 2.99438
WDR76 WD repeat domain 76 2.97123
HBB hemoglobin, beta 2.84327
GATA2 GATA binding protein 2 2.73041
ANXA10 annexin A10 2.54636
CPA1 carboxypeptidase A1 (pancreatic) 2.50046
GOLGA8A golgin A8 family, member A 2.46161
AADAC arylacetamide deacetylase 2.44949
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.39436
TRAPPC6A trafficking protein particle complex 6A 2.38015
TRIM46 tripartite motif containing 46 2.37774
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.35738
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.34823
HPR haptoglobin-related protein 2.34709
APMAP adipocyte plasma membrane associated protein 2.34467
STK10 serine/threonine kinase 10 2.33582
NOD1 nucleotide-binding oligomerization domain containing 1 2.33167
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.32451
HSFX2 heat shock transcription factor family, X linked 2 2.32426
HOXA10 homeobox A10 2.32145
PRR7 proline rich 7 (synaptic) 2.31582
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.30777
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.29742
KLHL35 kelch-like family member 35 2.29165
RGSL1 regulator of G-protein signaling like 1 2.28471
NTSR1 neurotensin receptor 1 (high affinity) 2.27932
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 2.26924
FOXE3 forkhead box E3 2.2674
RAG2 recombination activating gene 2 2.25912
ALOX15 arachidonate 15-lipoxygenase 2.25728
NME8 NME/NM23 family member 8 2.25091
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.24809
C8A complement component 8, alpha polypeptide 2.24421
RUSC2 RUN and SH3 domain containing 2 2.24284
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.23867
H2AB2 H2A.B variant histone 2 2.23548
NDOR1 NADPH dependent diflavin oxidoreductase 1 2.23443
USP29 ubiquitin specific peptidase 29 2.22009
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.21468
LMOD1 leiomodin 1 (smooth muscle) 2.20592
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 2.20343
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.19277
OR2B2 olfactory receptor, family 2, subfamily B, member 2 2.18811
SLC17A2 solute carrier family 17, member 2 2.17329
NALF2 NALCN channel auxiliary factor 2 2.17041
AQP7 aquaporin 7 2.16557
OTC ornithine carbamoyltransferase 2.1598
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.1559
APCS amyloid P component, serum 2.15454
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.15439
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.15187
NEIL1 nei endonuclease VIII-like 1 (E. coli) 2.14982
ASGR1 asialoglycoprotein receptor 1 2.14276
RRH retinal pigment epithelium-derived rhodopsin homolog 2.14191
LOC100996750 keratin-associated protein 4-7 2.13425
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.13017
POM121L2 POM121 transmembrane nucleoporin-like 2 2.12731
CISH cytokine inducible SH2-containing protein 2.1238
INTS1 integrator complex subunit 1 2.1209
NBEAL2 neurobeachin-like 2 2.11769
IL19 interleukin 19 2.10249
LECT2 leukocyte cell-derived chemotaxin 2 2.10083
TNN tenascin N 2.09343
MMP1 matrix metallopeptidase 1 2.08927
ARC activity-regulated cytoskeleton-associated protein 2.08846
SLC66A3 solute carrier family 66 member 3 2.08485
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.08141
ZFR2 zinc finger RNA binding protein 2 2.07957
CAPN11 calpain 11 2.07191
FAM120C family with sequence similarity 120C 2.06809
BRDT bromodomain, testis-specific 2.06796
IAPP islet amyloid polypeptide 2.06258
MDM4 MDM4, p53 regulator 2.05502
ZNF221 zinc finger protein 221 2.05467
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 2.05288
DUSP28 dual specificity phosphatase 28 2.04569
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 2.04519
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.04491
OR7A17 olfactory receptor, family 7, subfamily A, member 17 2.04333
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 2.04218
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 2.04189
HHEX hematopoietically expressed homeobox 2.03591
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 2.03464
MTA2 metastasis associated 1 family, member 2 2.03094
GRK4 G protein-coupled receptor kinase 4 2.02849
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 2.02808
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.02766
IFNA21 interferon, alpha 21 2.02246
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 2.01962
S1PR2 sphingosine-1-phosphate receptor 2 2.01892
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.01699
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 2.01452
ANGPTL3 angiopoietin-like 3 2.00552
GYS2 glycogen synthase 2 (liver) 2.00481
FAM76A family with sequence similarity 76, member A 2.00476

decreased expression

Symbol Name Standardized Value
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -6.17587
COTL1 coactosin-like F-actin binding protein 1 -4.52059
BAG3 BCL2-associated athanogene 3 -4.38452
UFM1 ubiquitin-fold modifier 1 -3.85486
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.50787
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.32734
NT5DC2 5'-nucleotidase domain containing 2 -3.10418
RPS5 ribosomal protein S5 -2.85115
EXOSC8 exosome component 8 -2.79568
CCNB2 cyclin B2 -2.49374
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.35072
ANXA2 annexin A2 -2.33782
PROSER1 proline and serine rich 1 -2.23766
TRIM44 tripartite motif containing 44 -2.16723
BASP1 brain abundant, membrane attached signal protein 1 -2.11399
CAPZB capping protein (actin filament) muscle Z-line, beta -2.07789
TSPAN3 tetraspanin 3 -2.05832
PTX3 pentraxin 3, long -2.02233