CRCGN015_MCF10A.TP53.M_24H:B08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2s)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid 32.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

128 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:B08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLSCR1 phospholipid scramblase 1 4.97832
KLHL21 kelch-like family member 21 4.97285
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 4.8843
ALG8 ALG8, alpha-1,3-glucosyltransferase 4.2827
CLNS1A chloride channel, nucleotide-sensitive, 1A 4.2793
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 4.0003
AAMDC adipogenesis associated, Mth938 domain containing 3.90623
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.76637
RSF1 remodeling and spacing factor 1 3.7166
TCTA T-cell leukemia translocation altered 3.2528
THAP12 THAP domain containing 12 3.1898
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.09565
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.8823
GAB2 GRB2-associated binding protein 2 2.88175
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.83085
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.7213
PRPS2 phosphoribosyl pyrophosphate synthetase 2 2.57125
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.54843
PKN1 protein kinase N1 2.54122
UBE2D1 ubiquitin-conjugating enzyme E2D 1 2.5311
PRPF3 pre-mRNA processing factor 3 2.43445
THAP1 THAP domain containing, apoptosis associated protein 1 2.39715
PARN poly(A)-specific ribonuclease 2.39665
VCP valosin containing protein 2.36153
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 2.3161
GAS6 growth arrest-specific 6 2.3047
TLCD3A TLC domain containing 3A 2.2489
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.2449
TMEM135 transmembrane protein 135 2.23865
SKA1 spindle and kinetochore associated complex subunit 1 2.2251
CARHSP1 calcium regulated heat stable protein 1, 24kDa 2.2229
MED17 mediator complex subunit 17 2.2173
RBM14-RBM4 RBM14-RBM4 readthrough 2.2119
TMEM186 transmembrane protein 186 2.21055
SLCO4C1 solute carrier organic anion transporter family, member 4C1 2.2085
LSR lipolysis stimulated lipoprotein receptor 2.191
PALM2AKAP2 PALM2 and AKAP2 fusion 2.1829
KRT16 keratin 16, type I 2.15315
WDR18 WD repeat domain 18 2.14945
PRMT7 protein arginine methyltransferase 7 2.14685
TSC1 tuberous sclerosis 1 2.1428
SP2 Sp2 transcription factor 2.13115
MAP3K8 mitogen-activated protein kinase kinase kinase 8 2.10345
UVRAG UV radiation resistance associated 2.1024
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 2.08468
GOLM1 golgi membrane protein 1 2.0704
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.05815
VPS35L VPS35 endosomal protein sorting factor like 2.03635
MYO5A myosin VA (heavy chain 12, myoxin) 2.01485
NDC1 NDC1 transmembrane nucleoporin 2.01405
AGR2 anterior gradient 2 2.011
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 2.00525
TCEA2 transcription elongation factor A (SII), 2 2.00425

decreased expression

Symbol Name Standardized Value
HAT1 histone acetyltransferase 1 -5.9483
ENOPH1 enolase-phosphatase 1 -5.6751
SCYL3 SCY1-like 3 (S. cerevisiae) -5.58908
NPDC1 neural proliferation, differentiation and control, 1 -5.0654
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.71925
LDHD lactate dehydrogenase D -4.66275
CD58 CD58 molecule -4.32213
GNAS GNAS complex locus -3.99684
COTL1 coactosin-like F-actin binding protein 1 -3.95765
LARP7 La ribonucleoprotein domain family, member 7 -3.1253
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -3.081
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -3.03067
GPR19 G protein-coupled receptor 19 -2.8294
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -2.75485
PTCD1 pentatricopeptide repeat domain 1 -2.7522
COG5 component of oligomeric golgi complex 5 -2.72662
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -2.72555
CKB creatine kinase, brain -2.7241
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -2.7159
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -2.71365
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.7077
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.488
CCT8 chaperonin containing TCP1, subunit 8 (theta) -2.44995
PPA1 pyrophosphatase (inorganic) 1 -2.4024
PMPCB peptidase (mitochondrial processing) beta -2.36893
PCCA propionyl CoA carboxylase, alpha polypeptide -2.366
PRELID3B PRELI domain containing 3B -2.3635
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -2.34965
COPS4 COP9 signalosome subunit 4 -2.34845
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.3269
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.31055
CTXND1 cortexin domain containing 1 -2.3103
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -2.30395
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.30095
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.29055
BUD31 BUD31 homolog (S. cerevisiae) -2.28385
IL1RAP interleukin 1 receptor accessory protein -2.28172
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide -2.2759
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -2.26705
ETFA electron-transfer-flavoprotein, alpha polypeptide -2.26155
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -2.2448
NAMPT nicotinamide phosphoribosyltransferase -2.2351
LAMB1 laminin, beta 1 -2.23172
GPR171 G protein-coupled receptor 171 -2.2062
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 -2.1962
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.1907
TMEM242 transmembrane protein 242 -2.1868
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 -2.1819
ISOC2 isochorismatase domain containing 2 -2.16535
QTMAN queuosine-tRNA mannosyltransferase -2.1648
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 -2.16205
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -2.1541
ATP5F1E ATP synthase F1 subunit epsilon -2.13145
HSF2BP heat shock transcription factor 2 binding protein -2.12725
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -2.1268
MXD3 MAX dimerization protein 3 -2.12115
MOSPD3 motile sperm domain containing 3 -2.11
IL2RB interleukin 2 receptor, beta -2.0977
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -2.09605
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific -2.09245
GRWD1 glutamate-rich WD repeat containing 1 -2.09145
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.0844
COL9A3 collagen, type IX, alpha 3 -2.0827
DYNLT1 dynein, light chain, Tctex-type 1 -2.0791
LRRN3 leucine rich repeat neuronal 3 -2.069
OMG oligodendrocyte myelin glycoprotein -2.06715
MEPE matrix extracellular phosphoglycoprotein -2.05205
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 -2.04383
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 -2.0425
HMGN1 high mobility group nucleosome binding domain 1 -2.01585
BCAP29 B-cell receptor-associated protein 29 -2.01075
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 -2.00985
S100B S100 calcium binding protein B -2.0038
SV2A synaptic vesicle glycoprotein 2A -2.00155
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.00145