CRCGN015_MCF10A.TP53.M_24H:B09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (2s)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid 10.77 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

219 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:B09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 5.8193
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.70995
TSEN2 TSEN2 tRNA splicing endonuclease subunit 5.0865
E2F2 E2F transcription factor 2 5.0
TLR4 toll-like receptor 4 4.82265
UGDH UDP-glucose 6-dehydrogenase 4.36695
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.2713
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 4.01652
KDM5D lysine (K)-specific demethylase 5D 3.82595
EPHB2 EPH receptor B2 3.72169
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.33115
AGO4 argonaute RISC catalytic component 4 3.2185
CDX2 caudal type homeobox 2 3.20765
SNCA synuclein, alpha (non A4 component of amyloid precursor) 3.08425
FPR2 formyl peptide receptor 2 2.96285
GUCY2C guanylate cyclase 2C 2.95615
TMEM186 transmembrane protein 186 2.9183
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.90317
GPA33 glycoprotein A33 (transmembrane) 2.8564
WASF3 WAS protein family, member 3 2.85185
SMG9 SMG9 nonsense mediated mRNA decay factor 2.83255
MCPH1 microcephalin 1 2.8094
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.77285
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.76935
NLGN4Y neuroligin 4, Y-linked 2.76455
SIRT3 sirtuin 3 2.75428
DPP6 dipeptidyl-peptidase 6 2.7341
ZFY zinc finger protein, Y-linked 2.69235
HBQ1 hemoglobin, theta 1 2.62965
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 2.6175
USP9Y ubiquitin specific peptidase 9, Y-linked 2.6126
DNAAF3 dynein, axonemal, assembly factor 3 2.60085
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.58178
STX11 syntaxin 11 2.5745
SLC68A1 solute carrier family 68 member 1 2.5644
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 2.54185
BLM Bloom syndrome, RecQ helicase-like 2.5347
TLR6 toll-like receptor 6 2.52475
PF4 platelet factor 4 2.5213
RUBCNL rubicon like autophagy enhancer 2.5201
NOX1 NADPH oxidase 1 2.50726
PRMT3 protein arginine methyltransferase 3 2.49165
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.48635
MSLN mesothelin 2.4851
CCN6 cellular communication network factor 6 2.48165
FABP1 fatty acid binding protein 1, liver 2.4765
TRAF3 TNF receptor-associated factor 3 2.4733
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.46605
LRRC61 leucine rich repeat containing 61 2.4642
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.43475
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.42645
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 2.4212
KANSL3 KAT8 regulatory NSL complex subunit 3 2.4182
SATB2 SATB homeobox 2 2.41547
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta 2.41465
TREM1 triggering receptor expressed on myeloid cells 1 2.4097
OMG oligodendrocyte myelin glycoprotein 2.4085
SAGE1 sarcoma antigen 1 2.3945
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 2.3901
BMP8B bone morphogenetic protein 8b 2.3825
GLRA2 glycine receptor, alpha 2 2.36605
HOXA2 homeobox A2 2.35615
AURKC aurora kinase C 2.34025
CBLN1 cerebellin 1 precursor 2.33355
CCDC88C coiled-coil domain containing 88C 2.32755
PTPRJ protein tyrosine phosphatase, receptor type, J 2.31575
MGMT O-6-methylguanine-DNA methyltransferase 2.31565
BLK BLK proto-oncogene, Src family tyrosine kinase 2.31465
PAX7 paired box 7 2.30775
SYNGR4 synaptogyrin 4 2.305
NRXN1 neurexin 1 2.29668
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 2.2966
MRPL11 mitochondrial ribosomal protein L11 2.27905
DAO D-amino-acid oxidase 2.2778
C5AR1 complement component 5a receptor 1 2.276
GTF2IRD1 GTF2I repeat domain containing 1 2.2701
EXOSC10 exosome component 10 2.2695
CDX1 caudal type homeobox 1 2.2678
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 2.2612
ERCC2 excision repair cross-complementation group 2 2.2511
KLHL7 kelch-like family member 7 2.24848
ATP9B ATPase, class II, type 9B 2.24145
TMOD2 tropomodulin 2 (neuronal) 2.22535
ZNF747 zinc finger protein 747 2.22315
DNMBP dynamin binding protein 2.21885
NTHL1 nth endonuclease III-like 1 (E. coli) 2.2154
MARCHF2 membrane associated ring-CH-type finger 2 2.2066
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 2.2049
FPR1 formyl peptide receptor 1 2.19963
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.1992
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.19705
CAMKMT calmodulin-lysine N-methyltransferase 2.1964
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 2.1954
DCAF4 DDB1 and CUL4 associated factor 4 2.1896
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 2.17817
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 2.1727
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 2.16862
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2.16665
TSHR thyroid stimulating hormone receptor 2.16155
TBCEL tubulin folding cofactor E-like 2.1593
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.15795
CAPN1 calpain 1, (mu/I) large subunit 2.1563
NT5M 5',3'-nucleotidase, mitochondrial 2.15155
HCRT hypocretin (orexin) neuropeptide precursor 2.14475
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.1331
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.12765
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 2.1242
RAG1 recombination activating gene 1 2.11755
MARK3 MAP/microtubule affinity-regulating kinase 3 2.1136
TUBAL3 tubulin, alpha-like 3 2.1111
GSPT1 G1 to S phase transition 1 2.1095
SLC26A3 solute carrier family 26 (anion exchanger), member 3 2.10945
MACROD1 MACRO domain containing 1 2.10875
ZNF428 zinc finger protein 428 2.0978
ZNHIT2 zinc finger, HIT-type containing 2 2.09695
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.0956
SIK3 SIK family kinase 3 2.09529
CAPN15 calpain 15 2.08485
TTI2 TELO2 interacting protein 2 2.0825
TRIM25 tripartite motif containing 25 2.0722
BEST2 bestrophin 2 2.069
HOXA10 homeobox A10 2.06572
KANK1 KN motif and ankyrin repeat domains 1 2.06085
METTL22 methyltransferase like 22 2.06075
UBE2D1 ubiquitin-conjugating enzyme E2D 1 2.05938
RBFA ribosome binding factor A (putative) 2.05825
ATOH1 atonal homolog 1 (Drosophila) 2.05795
UCKL1 uridine-cytidine kinase 1-like 1 2.05745
CA10 carbonic anhydrase X 2.05665
TMEM80 transmembrane protein 80 2.05495
RFX2 regulatory factor X, 2 (influences HLA class II expression) 2.0548
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 2.0538
POLR1G RNA polymerase I subunit G 2.05315
HOXB9 homeobox B9 2.0516
ARC activity-regulated cytoskeleton-associated protein 2.0494
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 2.0484
MCM10 minichromosome maintenance complex component 10 2.04795
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 2.0473
SQOR sulfide quinone oxidoreductase 2.0443
ADGRE2 adhesion G protein-coupled receptor E2 2.0443
SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1 2.04332
MEX3C mex-3 RNA binding family member C 2.038
HYI hydroxypyruvate isomerase (putative) 2.0373
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 2.0325
CCNP cyclin P 2.0302
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.0292
BMP3 bone morphogenetic protein 3 2.02415
FHIT fragile histidine triad 2.0239
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.02375
TM6SF1 transmembrane 6 superfamily member 1 2.0194
ZMAT3 zinc finger, matrin-type 3 2.0193
TLX1 T-cell leukemia homeobox 1 2.0187
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 2.01695
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 2.0103
IFNA21 interferon, alpha 21 2.0086
TMSB4Y thymosin beta 4, Y-linked 2.00685
CHD7 chromodomain helicase DNA binding protein 7 2.00575
OXTR oxytocin receptor 2.00335

decreased expression

Symbol Name Standardized Value
NUSAP1 nucleolar and spindle associated protein 1 -7.61422
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -5.17715
TUBB6 tubulin, beta 6 class V -5.0
RNF167 ring finger protein 167 -4.93725
DYNLT3 dynein, light chain, Tctex-type 3 -4.9064
CRTAP cartilage associated protein -4.3283
PSIP1 PC4 and SFRS1 interacting protein 1 -3.75758
KDM6A lysine (K)-specific demethylase 6A -2.9977
GFUS GDP-L-fucose synthase -2.85952
ZWINT ZW10 interacting kinetochore protein -2.82825
TUBA4A tubulin, alpha 4a -2.8233
UBA1 ubiquitin-like modifier activating enzyme 1 -2.80145
SMC1A structural maintenance of chromosomes 1A -2.79857
KDM3A lysine (K)-specific demethylase 3A -2.76895
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.70127
RRM2 ribonucleotide reductase M2 -2.6941
TOR1AIP2 torsin A interacting protein 2 -2.6841
PRKACB protein kinase, cAMP-dependent, catalytic, beta -2.63208
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.6193
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -2.56305
KDM5C lysine (K)-specific demethylase 5C -2.42005
RGS2 regulator of G-protein signaling 2 -2.3927
MFAP1 microfibrillar-associated protein 1 -2.35915
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.32645
HMGN1 high mobility group nucleosome binding domain 1 -2.3244
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -2.3061
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -2.29133
LIMA1 LIM domain and actin binding 1 -2.28005
ACTA2 actin, alpha 2, smooth muscle, aorta -2.22445
PCLAF PCNA clamp associated factor -2.22245
CDC37L1 cell division cycle 37-like 1 -2.19945
C1QBP complement component 1, q subcomponent binding protein -2.15902
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.15865
RACGAP1 Rac GTPase activating protein 1 -2.15605
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 -2.14715
WLS wntless Wnt ligand secretion mediator -2.1308
CD164 CD164 molecule, sialomucin -2.12598
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 -2.1204
TRAPPC2 trafficking protein particle complex 2 -2.11658
PRC1 protein regulator of cytokinesis 1 -2.11525
ARHGAP10 Rho GTPase activating protein 10 -2.11325
PROM1 prominin 1 -2.11295
CBR3 carbonyl reductase 3 -2.09385
MCM3 minichromosome maintenance complex component 3 -2.09375
SGK1 serum/glucocorticoid regulated kinase 1 -2.09295
LCN2 lipocalin 2 -2.0758
S100A7 S100 calcium binding protein A7 -2.06575
JAK1 Janus kinase 1 -2.0605
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -2.05585
MSN moesin -2.05515
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 -2.05265
AK4 adenylate kinase 4 -2.05097
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -2.0464
FAM32A family with sequence similarity 32, member A -2.0344
TSPOAP1 TSPO associated protein 1 -2.0286
LOC128125814 uncharacterized LOC128125814 -2.02805
TMEM47 transmembrane protein 47 -2.02238
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 -2.0191
PRR13 proline rich 13 -2.01115
TBC1D15 TBC1 domain family, member 15 -2.0086
GTF2A2 general transcription factor IIA, 2, 12kDa -2.0081