CRCGN015_MCF10A.TP53.M_24H:B12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfuric acid compound with 2-methyl-1,4-benzenediamine (1:1) 11.15 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

76 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:B12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.6779
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.4922
PECR peroxisomal trans-2-enoyl-CoA reductase 2.9484
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.80353
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.77685
TXNRD1 thioredoxin reductase 1 2.6906
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.61485
LOC107987462 leukocyte immunoglobulin-like receptor subfamily B member 3 2.5757
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.54375
CTSL cathepsin L 2.4476
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 2.37448
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 2.3591
LRRC31 leucine rich repeat containing 31 2.33275
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 2.29295
CDC25B cell division cycle 25B 2.20165
TSKU tsukushi, small leucine rich proteoglycan 2.1791
TPGS1 tubulin polyglutamylase complex subunit 1 2.1729
FGL1 fibrinogen-like 1 2.16945
ASCC3 activating signal cointegrator 1 complex subunit 3 2.1485
CXCL14 chemokine (C-X-C motif) ligand 14 2.12745
SDCBP syndecan binding protein (syntenin) 2.1223
USF2 upstream transcription factor 2, c-fos interacting 2.09037
SLC35B1 solute carrier family 35, member B1 2.04465
SAA4 serum amyloid A4, constitutive 2.00605
RHOT2 ras homolog family member T2 2.0039
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.00345

decreased expression

Symbol Name Standardized Value
TUBB6 tubulin, beta 6 class V -10.0
BASP1 brain abundant, membrane attached signal protein 1 -6.15465
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -5.52837
ANXA2 annexin A2 -5.21892
TM9SF3 transmembrane 9 superfamily member 3 -4.93135
PRPF4 pre-mRNA processing factor 4 -4.6634
PCNA proliferating cell nuclear antigen -4.66275
COG2 component of oligomeric golgi complex 2 -4.58485
COTL1 coactosin-like F-actin binding protein 1 -4.45115
PSIP1 PC4 and SFRS1 interacting protein 1 -3.75578
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.47552
NXT1 nuclear transport factor 2-like export factor 1 -3.37325
CD320 CD320 molecule -3.08185
LINC02762 long intergenic non-protein coding RNA 2762 -2.8963
RGS2 regulator of G-protein signaling 2 -2.8734
NLRP4 NLR family, pyrin domain containing 4 -2.81675
PANK2 pantothenate kinase 2 -2.7297
TMEM230 transmembrane protein 230 -2.6008
NT5DC2 5'-nucleotidase domain containing 2 -2.50425
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -2.5016
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.49155
LGALS1 lectin, galactoside-binding, soluble, 1 -2.48835
RAB13 RAB13, member RAS oncogene family -2.4287
TOR1A torsin family 1, member A (torsin A) -2.4231
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.39005
GRWD1 glutamate-rich WD repeat containing 1 -2.33165
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.3138
MAGEH1 melanoma antigen family H1 -2.30715
RPS5 ribosomal protein S5 -2.30275
NR4A2 nuclear receptor subfamily 4, group A, member 2 -2.27468
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.26518
MXRA7 matrix-remodelling associated 7 -2.21945
DACH1 dachshund family transcription factor 1 -2.19723
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.1397
MRPL16 mitochondrial ribosomal protein L16 -2.13385
SPPL2A signal peptide peptidase like 2A -2.12305
ADIRF adipogenesis regulatory factor -2.1083
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.1044
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.1031
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.09905
EMC8 ER membrane protein complex subunit 8 -2.09865
TRAPPC4 trafficking protein particle complex 4 -2.07247
TRAPPC2L trafficking protein particle complex 2-like -2.05805
HMGN2 high mobility group nucleosomal binding domain 2 -2.05705
RPA3 replication protein A3, 14kDa -2.05675
CAV1 caveolin 1, caveolae protein, 22kDa -2.05605
UBE2A ubiquitin-conjugating enzyme E2A -2.04285
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.019
TKTL1 transketolase-like 1 -2.00592
CDKN2AIP CDKN2A interacting protein -2.0027