CRCGN015_MCF10A.TP53.M_24H:B15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hp163 perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:B15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 5.66385
ALDOC aldolase C, fructose-bisphosphate 5.03805
INTS3 integrator complex subunit 3 4.9917
SSBP2 single-stranded DNA binding protein 2 4.53245
SPAG4 sperm associated antigen 4 4.4959
LGMN legumain 3.3786
TPD52L2 tumor protein D52-like 2 2.9737
TXNRD1 thioredoxin reductase 1 2.58255
TMEM47 transmembrane protein 47 2.41978
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.30285
TLCD3A TLC domain containing 3A 2.28715
MMP1 matrix metallopeptidase 1 2.03463
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 2.0211
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.01575

decreased expression

Symbol Name Standardized Value
GOLT1B golgi transport 1B -5.3869
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.0024
RPIA ribose 5-phosphate isomerase A -4.8912
HSPA8 heat shock 70kDa protein 8 -4.40833
CD58 CD58 molecule -3.82108
FOS FBJ murine osteosarcoma viral oncogene homolog -3.56155
CORO1A coronin, actin binding protein, 1A -3.37755
CLTB clathrin, light chain B -3.16169
TOR1A torsin family 1, member A (torsin A) -2.83057
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.6871
FAIM Fas apoptotic inhibitory molecule -2.60955
NT5DC2 5'-nucleotidase domain containing 2 -2.48305
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.46032
DUSP14 dual specificity phosphatase 14 -2.35725
CDK3 cyclin-dependent kinase 3 -2.3171
CCT8 chaperonin containing TCP1, subunit 8 (theta) -2.15625
DAPL1 death associated protein-like 1 -2.13685
LIN7B lin-7 homolog B (C. elegans) -2.13295
RECQL RecQ helicase-like -2.07371
RPS5 ribosomal protein S5 -2.0736
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 -2.0649
MRAS muscle RAS oncogene homolog -2.01575