CRCGN015_MCF10A.TP53.M_24H:B16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description beta-naphthoflavone 100.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

92 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:B16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.29335
MEF2C myocyte enhancer factor 2C 5.25217
KDM5D lysine (K)-specific demethylase 5D 4.5363
CCL2 chemokine (C-C motif) ligand 2 4.1081
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 4.01552
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 4.00865
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.97242
CCDC92 coiled-coil domain containing 92 3.9569
ITFG1 integrin alpha FG-GAP repeat containing 1 3.77725
USP9Y ubiquitin specific peptidase 9, Y-linked 3.6341
STAMBP STAM binding protein 3.2457
EPN2 epsin 2 3.19712
NLGN4Y neuroligin 4, Y-linked 2.9879
MYL11 myosin light chain 11 2.92985
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 2.79585
CKM creatine kinase, muscle 2.69105
IL12RB2 interleukin 12 receptor, beta 2 2.6688
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.65645
GSTT1 glutathione S-transferase theta 1 2.6558
MYL1 myosin, light chain 1, alkali; skeletal, fast 2.64305
TNNI1 troponin I type 1 (skeletal, slow) 2.59945
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.56975
IL1B interleukin 1, beta 2.55872
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.53058
ZFY zinc finger protein, Y-linked 2.50125
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.50005
NRBF2 nuclear receptor binding factor 2 2.4388
GDF10 growth differentiation factor 10 2.4177
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.39857
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.34495
GPATCH1 G patch domain containing 1 2.33705
MMRN1 multimerin 1 2.3035
SYNPO2L synaptopodin 2-like 2.3018
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.29525
CADPS2 Ca++-dependent secretion activator 2 2.2552
PECR peroxisomal trans-2-enoyl-CoA reductase 2.2469
CD226 CD226 molecule 2.2448
TPM3 tropomyosin 3 2.22345
GPER1 G protein-coupled estrogen receptor 1 2.19012
ASTN1 astrotactin 1 2.15205
LRP1B low density lipoprotein receptor-related protein 1B 2.1519
KRT16 keratin 16, type I 2.1418
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 2.14105
PANK4 pantothenate kinase 4 2.13975
TLE2 transducin-like enhancer of split 2 2.13573
KRT6B keratin 6B, type II 2.1347
TNNC2 troponin C type 2 (fast) 2.12995
NISCH nischarin 2.1232
TBXA2R thromboxane A2 receptor 2.1033
RIT2 Ras-like without CAAX 2 2.08285
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 2.0763
TPD52L2 tumor protein D52-like 2 2.07315
TUBB4A tubulin, beta 4A class IVa 2.0605
GPR22 G protein-coupled receptor 22 2.0577
TNF tumor necrosis factor 2.0565
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.047
MYL2 myosin, light chain 2, regulatory, cardiac, slow 2.04005
MACROD1 MACRO domain containing 1 2.02325
ZNF365 zinc finger protein 365 2.0228
GRB7 growth factor receptor-bound protein 7 2.0103
ACTA1 actin, alpha 1, skeletal muscle 2.00105

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -5.44835
TUBB6 tubulin, beta 6 class V -5.1988
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.97625
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.78815
KDM5C lysine (K)-specific demethylase 5C -3.7546
NUSAP1 nucleolar and spindle associated protein 1 -3.46895
ANXA2 annexin A2 -3.1504
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -3.08465
CDK4 cyclin-dependent kinase 4 -3.0822
FPGS folylpolyglutamate synthase -3.03975
SMC1A structural maintenance of chromosomes 1A -2.8777
NGRN neugrin, neurite outgrowth associated -2.8568
BASP1 brain abundant, membrane attached signal protein 1 -2.54885
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.51997
OFD1 oral-facial-digital syndrome 1 -2.39375
GFUS GDP-L-fucose synthase -2.36845
IQCC IQ motif containing C -2.3192
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific -2.29965
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.2963
HSPA1A heat shock 70kDa protein 1A -2.2936
KDM6A lysine (K)-specific demethylase 6A -2.28997
OSR2 odd-skipped related transciption factor 2 -2.16255
ARB2A ARB2 cotranscriptional regulator A -2.14585
MTIF2 mitochondrial translational initiation factor 2 -2.13385
UBA1 ubiquitin-like modifier activating enzyme 1 -2.0778
PIH1D1 PIH1 domain containing 1 -2.0617
ADI1 acireductone dioxygenase 1 -2.06055
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 -2.0596
CPNE3 copine III -2.05578
STXBP2 syntaxin binding protein 2 -2.0237
MMD monocyte to macrophage differentiation-associated -2.0016