CRCGN015_MCF10A.TP53.M_24H:B17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description beta-naphthoflavone 33.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

314 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:B17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.8192
E2F2 E2F transcription factor 2 5.3732
CASP2 caspase 2, apoptosis-related cysteine peptidase 5.17522
GRB10 growth factor receptor-bound protein 10 4.74623
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.5153
MAST2 microtubule associated serine/threonine kinase 2 4.07892
MTA2 metastasis associated 1 family, member 2 3.99665
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.9531
VGLL4 vestigial-like family member 4 3.9214
MDM4 MDM4, p53 regulator 3.90235
GPATCH8 G patch domain containing 8 3.38675
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.2238
PTPRS protein tyrosine phosphatase, receptor type, S 3.178
ZNF318 zinc finger protein 318 3.13735
GADD45A growth arrest and DNA-damage-inducible, alpha 3.066
TNN tenascin N 2.9973
KERA keratocan 2.91415
YOD1 YOD1 deubiquitinase 2.8076
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 2.78585
ZNF549 zinc finger protein 549 2.77725
IFNA2 interferon, alpha 2 2.74945
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 2.74
COMP cartilage oligomeric matrix protein 2.6936
LOC102724652 alpha-crystallin A chain 2.67225
ZNF460 zinc finger protein 460 2.629
ADGB androglobin 2.61345
DCAF1 DDB1 and CUL4 associated factor 1 2.61338
TXK TXK tyrosine kinase 2.55825
LDHAL6B lactate dehydrogenase A-like 6B 2.5495
KRT36 keratin 36, type I 2.53375
IMPG1 interphotoreceptor matrix proteoglycan 1 2.5278
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.5255
LARS2 leucyl-tRNA synthetase 2, mitochondrial 2.52043
NRDE2 NRDE-2, necessary for RNA interference, domain containing 2.516
ZNF780B zinc finger protein 780B 2.5147
ADRB1 adrenoceptor beta 1 2.50695
PARD6B par-6 family cell polarity regulator beta 2.50542
IL4 interleukin 4 2.50455
TBC1D22B TBC1 domain family, member 22B 2.49485
SLC35F5 solute carrier family 35, member F5 2.47575
TBC1D31 TBC1 domain family, member 31 2.4696
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 2.46775
DIAPH3 diaphanous-related formin 3 2.4641
FBXO24 F-box protein 24 2.4632
RBMXL2 RNA binding motif protein, X-linked-like 2 2.4565
ZNF234 zinc finger protein 234 2.44595
PRELID3A PRELI domain containing 3A 2.44065
HYAL4 hyaluronoglucosaminidase 4 2.43485
PPP4R3B protein phosphatase 4 regulatory subunit 3B 2.42875
PURG purine-rich element binding protein G 2.42875
ANKRD7 ankyrin repeat domain 7 2.42585
CABP5 calcium binding protein 5 2.42465
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 2.4181
PECR peroxisomal trans-2-enoyl-CoA reductase 2.4116
DBF4B DBF4 zinc finger B 2.41115
SEC14L4 SEC14-like 4 (S. cerevisiae) 2.4031
OR3A2 olfactory receptor, family 3, subfamily A, member 2 2.3991
BTG4 B-cell translocation gene 4 2.3832
ZNF471 zinc finger protein 471 2.382
ARHGAP28 Rho GTPase activating protein 28 2.38135
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.37905
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 2.37435
DCAKD dephospho-CoA kinase domain containing 2.37383
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.37085
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.355
RFX3 regulatory factor X, 3 (influences HLA class II expression) 2.355
SPO11 SPO11 meiotic protein covalently bound to DSB 2.35205
THAP9 THAP domain containing 9 2.34455
HKDC1 hexokinase domain containing 1 2.34345
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 2.33855
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 2.3374
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.33512
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 2.33425
ALOX12B arachidonate 12-lipoxygenase, 12R type 2.3314
WRNIP1 Werner helicase interacting protein 1 2.33115
DMRT1 doublesex and mab-3 related transcription factor 1 2.3311
UBQLN3 ubiquilin 3 2.32555
TLL1 tolloid-like 1 2.32535
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 2.32485
FOXL1 forkhead box L1 2.32385
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.3236
EPB41 erythrocyte membrane protein band 4.1 2.32028
GPR25 G protein-coupled receptor 25 2.31775
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.31325
ZNF254 zinc finger protein 254 2.3112
THRAP3 thyroid hormone receptor associated protein 3 2.30515
SOCS2 suppressor of cytokine signaling 2 2.30408
HOXA2 homeobox A2 2.30185
TEX28 testis expressed 28 2.30065
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.2996
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.29665
EFNA2 ephrin-A2 2.29295
TRMT9B tRNA methyltransferase 9B (putative) 2.29025
DAZL deleted in azoospermia-like 2.28785
MTRF1L mitochondrial translational release factor 1-like 2.28365
USH2A Usher syndrome 2A (autosomal recessive, mild) 2.2805
TSSK2 testis-specific serine kinase 2 2.2774
ACOXL acyl-CoA oxidase-like 2.27725
PDPN podoplanin 2.27058
INSL6 insulin-like 6 2.27035
LGALS12 lectin, galactoside-binding, soluble, 12 2.26875
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.267
ADAM2 ADAM metallopeptidase domain 2 2.2635
UNC93A unc-93 homolog A (C. elegans) 2.26145
TAS2R4 taste receptor, type 2, member 4 2.2583
AGBL3 ATP/GTP binding protein-like 3 2.25735
OR2W1 olfactory receptor, family 2, subfamily W, member 1 2.25565
TACR3 tachykinin receptor 3 2.25445
INCENP inner centromere protein antigens 135/155kDa 2.2516
CFAP68 cilia and flagella associated protein 68 2.25155
ZIC4 Zic family member 4 2.2501
PBOV1 prostate and breast cancer overexpressed 1 2.24995
ATXN3L ataxin 3-like 2.2499
MCHR1 melanin-concentrating hormone receptor 1 2.249
RXFP3 relaxin/insulin-like family peptide receptor 3 2.24875
CDC14A cell division cycle 14A 2.24831
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 2.24638
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 2.24045
JAK3 Janus kinase 3 2.23695
OR2J2 olfactory receptor, family 2, subfamily J, member 2 2.23685
SCN7A sodium channel, voltage gated, type VII alpha subunit 2.23515
ANP32D acidic (leucine-rich) nuclear phosphoprotein 32 family, member D 2.234
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 2.2328
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.2319
ZNF334 zinc finger protein 334 2.23015
ETV3 ets variant 3 2.2289
ACHE acetylcholinesterase (Yt blood group) 2.22853
RAVER2 ribonucleoprotein, PTB-binding 2 2.22835
DOT1L DOT1-like histone H3K79 methyltransferase 2.2259
DGKE diacylglycerol kinase, epsilon 64kDa 2.2255
HOXD12 homeobox D12 2.22395
ZNF157 zinc finger protein 157 2.2221
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 2.21795
NMBR neuromedin B receptor 2.21625
VCPKMT valosin containing protein lysine (K) methyltransferase 2.216
USP27X ubiquitin specific peptidase 27, X-linked 2.2133
CRYBA1 crystallin, beta A1 2.21165
ZBTB33 zinc finger and BTB domain containing 33 2.21105
MYLK3 myosin light chain kinase 3 2.2081
KDM4D lysine (K)-specific demethylase 4D 2.2063
LPAR4 lysophosphatidic acid receptor 4 2.20225
FGF18 fibroblast growth factor 18 2.19708
VPS50 VPS50 subunit of EARP/GARPII complex 2.1966
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.1913
IFT54 intraflagellar transport 54 2.1874
MC3R melanocortin 3 receptor 2.1823
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 2.18155
KRTAP2-3 keratin associated protein 2-3 2.1813
EPHA1 EPH receptor A1 2.17995
IFNA8 interferon, alpha 8 2.1729
JPH2 junctophilin 2 2.1693
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 2.16665
TNMD tenomodulin 2.1662
TBL1Y transducin (beta)-like 1, Y-linked 2.1646
RFPL1 ret finger protein-like 1 2.16395
KRT85 keratin 85, type II 2.1638
FOXD3 forkhead box D3 2.1633
HOXB8 homeobox B8 2.1594
MLNR motilin receptor 2.1581
ASB1 ankyrin repeat and SOCS box containing 1 2.15712
ZNF391 zinc finger protein 391 2.1568
WT1 Wilms tumor 1 2.1561
IFNA5 interferon, alpha 5 2.15325
PAEP progestagen-associated endometrial protein 2.15135
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 2.14992
SPATA31C1 SPATA31 subfamily C, member 1 2.14955
FAM13C family with sequence similarity 13, member C 2.1471
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 2.1456
SPACA1 sperm acrosome associated 1 2.14525
CCN6 cellular communication network factor 6 2.14445
LMX1B LIM homeobox transcription factor 1, beta 2.1442
TULP2 tubby like protein 2 2.1438
TRIM49B tripartite motif containing 49B 2.14155
S100G S100 calcium binding protein G 2.13835
XCR1 chemokine (C motif) receptor 1 2.1361
KLK15 kallikrein-related peptidase 15 2.13565
SNTG2 syntrophin, gamma 2 2.13415
GLRA1 glycine receptor, alpha 1 2.1329
CNTN6 contactin 6 2.129
SOX14 SRY (sex determining region Y)-box 14 2.12875
AMELX amelogenin, X-linked 2.12805
PDE12 phosphodiesterase 12 2.12485
OR11A1 olfactory receptor, family 11, subfamily A, member 1 2.12445
ZNF81 zinc finger protein 81 2.123
TRPC5 transient receptor potential cation channel, subfamily C, member 5 2.12285
OR2J3 olfactory receptor, family 2, subfamily J, member 3 2.12265
ASCL2 achaete-scute family bHLH transcription factor 2 2.12175
WNT1 wingless-type MMTV integration site family, member 1 2.11975
ZNF493 zinc finger protein 493 2.1193
KRT35 keratin 35, type I 2.11865
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.1176
RUNX2 runt-related transcription factor 2 2.11748
OR1D4 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) 2.1156
H2AP H2A.P histone 2.1153
POU1F1 POU class 1 homeobox 1 2.11365
GUCY2F guanylate cyclase 2F, retinal 2.1119
TAPT1 transmembrane anterior posterior transformation 1 2.11145
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.10865
WDR76 WD repeat domain 76 2.10775
EPHA5 EPH receptor A5 2.107
TAS2R7 taste receptor, type 2, member 7 2.10695
TEX12 testis expressed 12 2.1051
RBBP5 retinoblastoma binding protein 5 2.10345
GCM2 glial cells missing homolog 2 (Drosophila) 2.10275
PHAF1 phagosome assembly factor 1 2.1008
NOX3 NADPH oxidase 3 2.1006
DEGS1 delta(4)-desaturase, sphingolipid 1 2.09753
ADRA1D adrenoceptor alpha 1D 2.0917
H4C7 H4 clustered histone 7 2.0907
TAS2R9 taste receptor, type 2, member 9 2.08795
ZNF236 zinc finger protein 236 2.08745
ZNF749 zinc finger protein 749 2.08705
SLC25A30 solute carrier family 25, member 30 2.08655
TSSK1B testis-specific serine kinase 1B 2.086
TAS2R13 taste receptor, type 2, member 13 2.08525
RCVRN recoverin 2.0848
TEX14 testis expressed 14 2.08155
NEUROG3 neurogenin 3 2.08135
PRDM16 PR domain containing 16 2.0805
TRPC3 transient receptor potential cation channel, subfamily C, member 3 2.08037
CFAP46 cilia and flagella associated protein 46 2.0793
LIM2 lens intrinsic membrane protein 2, 19kDa 2.07795
BTC betacellulin 2.0779
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2.0773
GNRHR gonadotropin-releasing hormone receptor 2.07383
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 2.0727
NOSIP nitric oxide synthase interacting protein 2.07075
MYH15 myosin, heavy chain 15 2.06865
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.06755
ZNF286A zinc finger protein 286A 2.06725
RNF144A ring finger protein 144A 2.0669
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 2.0664
VIL1 villin 1 2.06255
NKX6-1 NK6 homeobox 1 2.05925
ZNF674 zinc finger protein 674 2.05875
BMP15 bone morphogenetic protein 15 2.05865
SHH sonic hedgehog 2.05855
POLR1F RNA polymerase I subunit F 2.05715
GPR135 G protein-coupled receptor 135 2.0551
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.0549
DRD3 dopamine receptor D3 2.0542
FGF8 fibroblast growth factor 8 (androgen-induced) 2.05375
GSC2 goosecoid homeobox 2 2.05345
GRIK3 glutamate receptor, ionotropic, kainate 3 2.0533
PKD2L2 polycystic kidney disease 2-like 2 2.0525
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide 2.0518
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 2.0513
TENM1 teneurin transmembrane protein 1 2.05095
KRTAP1-3 keratin associated protein 1-3 2.0508
SPATA1 spermatogenesis associated 1 2.0497
POU4F2 POU class 4 homeobox 2 2.0488
AGO4 argonaute RISC catalytic component 4 2.04845
KRTAP9-9 keratin associated protein 9-9 2.048
NOL10 nucleolar protein 10 2.04725
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.0444
NPBWR2 neuropeptides B/W receptor 2 2.0427
ELOA2 elongin A2 2.0415
LCOR ligand dependent nuclear receptor corepressor 2.0413
SPATA31A3 SPATA31 subfamily A, member 3 2.04065
ZNF257 zinc finger protein 257 2.0392
MYEF2 myelin expression factor 2 2.03745
CCNK cyclin K 2.03625
PDZRN4 PDZ domain containing ring finger 4 2.03465
ADAM18 ADAM metallopeptidase domain 18 2.03275
TSKS testis-specific serine kinase substrate 2.03023
GP5 glycoprotein V (platelet) 2.02795
TMOD2 tropomodulin 2 (neuronal) 2.0266
GSG1 germ cell associated 1 2.0263
MTMR7 myotubularin related protein 7 2.02565
BPHL biphenyl hydrolase-like (serine hydrolase) 2.0256
NLGN4Y neuroligin 4, Y-linked 2.0246
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.0237
PTGFR prostaglandin F receptor (FP) 2.02345
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.02165
AKAP5 A kinase (PRKA) anchor protein 5 2.0216
DNASE2B deoxyribonuclease II beta 2.0208
MAGEB3 melanoma antigen family B3 2.0207
FLT4 fms-related tyrosine kinase 4 2.01895
H3-4 H3.4 histone, cluster member 2.01895
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 2.01615
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.01585
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2.01585
H1-1 H1.1 linker histone, cluster member 2.01435
TRIM58 tripartite motif containing 58 2.0132
TRDN triadin 2.01275
GPR173 G protein-coupled receptor 173 2.01155
NR0B2 nuclear receptor subfamily 0, group B, member 2 2.01015
OR7E24 olfactory receptor, family 7, subfamily E, member 24 2.00995
LOC100996750 keratin-associated protein 4-7 2.00765
ACSM1 acyl-CoA synthetase medium-chain family member 1 2.0055
GTPBP10 GTP-binding protein 10 (putative) 2.00355
CCL15 chemokine (C-C motif) ligand 15 2.00085
PRPF39 pre-mRNA processing factor 39 2.00035

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -5.8522
TMEM109 transmembrane protein 109 -4.95615
HMG20B high mobility group 20B -4.4686
NT5DC2 5'-nucleotidase domain containing 2 -3.25295
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.1203
RAI14 retinoic acid induced 14 -3.0069
TOR1A torsin family 1, member A (torsin A) -2.79055
BASP1 brain abundant, membrane attached signal protein 1 -2.71215
REEP5 receptor accessory protein 5 -2.69543
IPO13 importin 13 -2.6139
RPA3 replication protein A3, 14kDa -2.60765
DPP8 dipeptidyl-peptidase 8 -2.41985
CBR3 carbonyl reductase 3 -2.353
TPD52L1 tumor protein D52-like 1 -2.3305
PIH1D1 PIH1 domain containing 1 -2.1705
ILK integrin-linked kinase -2.165
CLNS1A chloride channel, nucleotide-sensitive, 1A -2.06365
COTL1 coactosin-like F-actin binding protein 1 -2.0412
SYNGR2 synaptogyrin 2 -2.0321
HPCAL1 hippocalcin-like 1 -2.01067
HAUS4 HAUS augmin-like complex, subunit 4 -2.00575