CRCGN015_MCF10A.TP53.M_24H:B19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibenz(a,h)anthracene 98.59 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:B19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.0593
SPAG4 sperm associated antigen 4 4.8842
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.8779
CNRIP1 cannabinoid receptor interacting protein 1 4.6705
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.52843
KIF5C kinesin family member 5C 4.34622
SYNE2 spectrin repeat containing, nuclear envelope 2 3.80465
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.73215
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.72152
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.6733
ACAA1 acetyl-CoA acyltransferase 1 3.51375
WASF3 WAS protein family, member 3 3.4269
NOTCH1 notch 1 3.1625
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.46775
CHN1 chimerin 1 2.3925
CFI complement factor I 2.28795
TMEM204 transmembrane protein 204 2.26915
IGFBP3 insulin-like growth factor binding protein 3 2.16655
IL1B interleukin 1, beta 2.11485
TRAM2 translocation associated membrane protein 2 2.09337
ITGA9 integrin, alpha 9 2.067
TLCD3A TLC domain containing 3A 2.03945

decreased expression

Symbol Name Standardized Value
CCDC86 coiled-coil domain containing 86 -5.4236
HMG20B high mobility group 20B -5.19635
PRPF4 pre-mRNA processing factor 4 -4.7079
THAP11 THAP domain containing 11 -4.4852
GRWD1 glutamate-rich WD repeat containing 1 -3.39035
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.31638
KDM3A lysine (K)-specific demethylase 3A -3.14895
NLRP4 NLR family, pyrin domain containing 4 -3.09425
DSG2 desmoglein 2 -2.91985
CDKN2A cyclin-dependent kinase inhibitor 2A -2.78115
RPS5 ribosomal protein S5 -2.48945
RGS2 regulator of G-protein signaling 2 -2.46175
GFUS GDP-L-fucose synthase -2.45238
ABITRAM actin binding transcription modulator -2.44245
CRTAP cartilage associated protein -2.36155
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.35285
BASP1 brain abundant, membrane attached signal protein 1 -2.33925
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.29895
MRPS2 mitochondrial ribosomal protein S2 -2.24855
MAP2K2 mitogen-activated protein kinase kinase 2 -2.13793
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.10165
CBR1 carbonyl reductase 1 -2.069
CD320 CD320 molecule -2.06075
INTS12 integrator complex subunit 12 -2.0481
DGCR6L DiGeorge syndrome critical region gene 6-like -2.03385