CRCGN015_MCF10A.TP53.M_24H:B21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibenz(a,h)anthracene 10.95 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

351 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:B21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HYOU1 hypoxia up-regulated 1 6.1541
BDH1 3-hydroxybutyrate dehydrogenase, type 1 5.4642
CCDC92 coiled-coil domain containing 92 5.413
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.3097
TLR4 toll-like receptor 4 5.24535
RPL39L ribosomal protein L39-like 5.14975
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.8651
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 4.46795
CCL2 chemokine (C-C motif) ligand 2 4.4514
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.26715
TBX2 T-box 2 4.10035
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.7387
EVL Enah/Vasp-like 3.50975
BEST1 bestrophin 1 3.506
AGR2 anterior gradient 2 3.4787
HBA1 hemoglobin, alpha 1 3.37715
SAMD9 sterile alpha motif domain containing 9 3.36615
OASL 2'-5'-oligoadenylate synthetase-like 3.33558
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.3261
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.18235
TPPP tubulin polymerization promoting protein 3.17415
RIN2 Ras and Rab interactor 2 3.17115
CD1D CD1d molecule 3.1703
SNX11 sorting nexin 11 3.08302
PDIA4 protein disulfide isomerase family A, member 4 3.01185
ADAMDEC1 ADAM-like, decysin 1 2.98745
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.98585
TLCD3A TLC domain containing 3A 2.98115
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.91255
IL33 interleukin 33 2.9058
PTAFR platelet-activating factor receptor 2.86885
RTP4 receptor (chemosensory) transporter protein 4 2.8531
CCDC88C coiled-coil domain containing 88C 2.84435
CCR1 chemokine (C-C motif) receptor 1 2.81472
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.8012
SMAD9 SMAD family member 9 2.7955
MX2 MX dynamin-like GTPase 2 2.77765
CNRIP1 cannabinoid receptor interacting protein 1 2.77385
CADM1 cell adhesion molecule 1 2.76892
MARK2 MAP/microtubule affinity-regulating kinase 2 2.7661
MFAP4 microfibrillar-associated protein 4 2.75965
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.73045
CCL15 chemokine (C-C motif) ligand 15 2.72225
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.7123
MUC13 mucin 13, cell surface associated 2.7119
RSAD2 radical S-adenosyl methionine domain containing 2 2.68035
C3AR1 complement component 3a receptor 1 2.6743
ADIRF adipogenesis regulatory factor 2.67045
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.66765
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.645
STX11 syntaxin 11 2.6438
CD300C CD300c molecule 2.6357
PRPF3 pre-mRNA processing factor 3 2.62975
TLR8 toll-like receptor 8 2.6036
PCDHA10 protocadherin alpha 10 2.6029
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2.6005
NT5M 5',3'-nucleotidase, mitochondrial 2.59745
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 2.5902
NINL ninein-like 2.5851
TCIM transcriptional and immune response regulator 2.57065
CCRL2 chemokine (C-C motif) receptor-like 2 2.568
GASK1B golgi associated kinase 1B 2.5606
CXCL11 chemokine (C-X-C motif) ligand 11 2.54655
LDOC1 leucine zipper, down-regulated in cancer 1 2.54635
SNX7 sorting nexin 7 2.5447
MX1 MX dynamin-like GTPase 1 2.54195
FPR2 formyl peptide receptor 2 2.5312
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.52415
POGK pogo transposable element with KRAB domain 2.5127
MMRN2 multimerin 2 2.51245
FGL2 fibrinogen-like 2 2.5124
SNN stannin 2.49573
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough 2.49533
CLEC7A C-type lectin domain family 7, member A 2.4952
RHOBTB2 Rho-related BTB domain containing 2 2.49335
RNF170 ring finger protein 170 2.4866
RGS5 regulator of G-protein signaling 5 2.48457
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.48135
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 2.48065
ST20-MTHFS ST20-MTHFS readthrough 2.47915
RNASE6 ribonuclease, RNase A family, k6 2.4762
ZNF467 zinc finger protein 467 2.4642
POLM polymerase (DNA directed), mu 2.46115
PRH1 proline-rich protein HaeIII subfamily 1 2.4497
RIGI RNA sensor RIG-I 2.4456
PLCH2 phospholipase C, eta 2 2.44525
SAMHD1 SAM domain and HD domain 1 2.43855
ARPP21 cAMP-regulated phosphoprotein, 21kDa 2.4249
MUC4 mucin 4, cell surface associated 2.42438
TLR1 toll-like receptor 1 2.4192
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.40935
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.4077
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 2.40592
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.3955
IFI27 interferon, alpha-inducible protein 27 2.39445
GPR132 G protein-coupled receptor 132 2.3883
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.3841
IL1B interleukin 1, beta 2.37435
GIMAP6 GTPase, IMAP family member 6 2.37385
DUOX2 dual oxidase 2 2.3705
ZNHIT2 zinc finger, HIT-type containing 2 2.36335
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 2.35655
CPE carboxypeptidase E 2.3563
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.3509
WT1 Wilms tumor 1 2.34777
GPR25 G protein-coupled receptor 25 2.3467
WDR7 WD repeat domain 7 2.3446
CAPN1 calpain 1, (mu/I) large subunit 2.34205
NPTN neuroplastin 2.3414
AOC3 amine oxidase, copper containing 3 2.3329
SLC44A1 solute carrier family 44 (choline transporter), member 1 2.33205
TMEM50B transmembrane protein 50B 2.3308
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.32625
PIGR polymeric immunoglobulin receptor 2.32255
NR0B2 nuclear receptor subfamily 0, group B, member 2 2.3045
TTI2 TELO2 interacting protein 2 2.3036
CAPN5 calpain 5 2.30065
NCF2 neutrophil cytosolic factor 2 2.29655
GULP1 GULP, engulfment adaptor PTB domain containing 1 2.29652
MANF mesencephalic astrocyte-derived neurotrophic factor 2.2962
CASP5 caspase 5, apoptosis-related cysteine peptidase 2.2948
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.27205
LYPD1 LY6/PLAUR domain containing 1 2.2714
PSKH1 protein serine kinase H1 2.27025
SIRPA signal-regulatory protein alpha 2.26557
HMG20A high mobility group 20A 2.2588
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.2553
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 2.25465
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.25338
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.2527
SYNPO synaptopodin 2.247
GDF10 growth differentiation factor 10 2.23995
PTPRJ protein tyrosine phosphatase, receptor type, J 2.23685
MYH10 myosin, heavy chain 10, non-muscle 2.2362
ADAMTSL2 ADAMTS-like 2 2.232
MAP2K5 mitogen-activated protein kinase kinase 5 2.23113
SCN7A sodium channel, voltage gated, type VII alpha subunit 2.21405
AOAH acyloxyacyl hydrolase (neutrophil) 2.21085
PDGFD platelet derived growth factor D 2.21005
UBASH3A ubiquitin associated and SH3 domain containing A 2.2083
CAPN9 calpain 9 2.20758
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.1981
STAU2 staufen double-stranded RNA binding protein 2 2.18985
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.18248
CLCA1 chloride channel accessory 1 2.18075
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 2.1795
GPR137B G protein-coupled receptor 137B 2.1727
TRIM22 tripartite motif containing 22 2.17005
CCL7 chemokine (C-C motif) ligand 7 2.16255
DPP8 dipeptidyl-peptidase 8 2.16155
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.15957
PANK2 pantothenate kinase 2 2.1585
NRIP2 nuclear receptor interacting protein 2 2.15535
ADRA2A adrenoceptor alpha 2A 2.15525
DMBT1 deleted in malignant brain tumors 1 2.1527
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.1511
TCF15 transcription factor 15 (basic helix-loop-helix) 2.14985
TREM1 triggering receptor expressed on myeloid cells 1 2.1473
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 2.14695
CYBB cytochrome b-245, beta polypeptide 2.14692
RGS9BP regulator of G protein signaling 9 binding protein 2.1426
JAG1 jagged 1 2.14016
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 2.13405
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.13065
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.12945
ZNF253 zinc finger protein 253 2.1292
IFI44L interferon-induced protein 44-like 2.1243
NAIP NLR family, apoptosis inhibitory protein 2.12385
CD86 CD86 molecule 2.12378
EDNRA endothelin receptor type A 2.1196
NEUROG3 neurogenin 3 2.1195
IL13RA1 interleukin 13 receptor, alpha 1 2.11324
MARCHF1 membrane associated ring-CH-type finger 1 2.11015
FABP2 fatty acid binding protein 2, intestinal 2.10915
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.1091
CORO7-PAM16 CORO7-PAM16 readthrough 2.10885
CCL11 chemokine (C-C motif) ligand 11 2.10715
FPR3 formyl peptide receptor 3 2.10495
BDKRB2 bradykinin receptor B2 2.10375
PRCC papillary renal cell carcinoma (translocation-associated) 2.10365
ADAP1 ArfGAP with dual PH domains 1 2.09667
ACE angiotensin I converting enzyme 2.09485
RSPH14 radial spoke head 14 homolog (Chlamydomonas) 2.09335
FHL5 four and a half LIM domains 5 2.09135
TLR7 toll-like receptor 7 2.08985
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.0885
LRRC19 leucine rich repeat containing 19 2.08605
TRIP4 thyroid hormone receptor interactor 4 2.0847
TRAPPC13 trafficking protein particle complex 13 2.08425
UBE2G1 ubiquitin-conjugating enzyme E2G 1 2.0801
DCAF10 DDB1 and CUL4 associated factor 10 2.0791
EPN3 epsin 3 2.0779
LRRC61 leucine rich repeat containing 61 2.0729
CD4 CD4 molecule 2.06105
PMM2 phosphomannomutase 2 2.0585
ZEB2 zinc finger E-box binding homeobox 2 2.0566
EXOC2 exocyst complex component 2 2.05595
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 2.05307
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 2.05285
TMEM144 transmembrane protein 144 2.0527
C5AR1 complement component 5a receptor 1 2.04975
SLC38A12 solute carrier family 38 member 12 2.0487
GTF2IRD2B GTF2I repeat domain containing 2B 2.04675
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 2.0463
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I 2.04455
SIGLEC9 sialic acid binding Ig-like lectin 9 2.04445
CKS1B CDC28 protein kinase regulatory subunit 1B 2.044
KIF16B kinesin family member 16B 2.0352
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 2.0351
PLEKHA6 pleckstrin homology domain containing, family A member 6 2.0347
MAP3K11 mitogen-activated protein kinase kinase kinase 11 2.0304
FKBP5 FK506 binding protein 5 2.0294
DEDD death effector domain containing 2.02732
UVRAG UV radiation resistance associated 2.0271
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.02685
TMC7 transmembrane channel-like 7 2.01795
XAF1 XIAP associated factor 1 2.0168
RNF111 ring finger protein 111 2.01545
ZNF646 zinc finger protein 646 2.00485

decreased expression

Symbol Name Standardized Value
NUSAP1 nucleolar and spindle associated protein 1 -7.46903
ADI1 acireductone dioxygenase 1 -5.5319
MRPS2 mitochondrial ribosomal protein S2 -5.41415
KIF20A kinesin family member 20A -5.39005
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.33705
NPDC1 neural proliferation, differentiation and control, 1 -4.9332
TRAPPC3 trafficking protein particle complex 3 -4.89587
HMG20B high mobility group 20B -4.77115
CANT1 calcium activated nucleotidase 1 -4.49832
CD44 CD44 molecule (Indian blood group) -4.25069
PPIC peptidylprolyl isomerase C (cyclophilin C) -4.21817
SORBS3 sorbin and SH3 domain containing 3 -3.56483
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.50885
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -3.46235
ENTR1 endosome associated trafficking regulator 1 -3.43545
PRC1 protein regulator of cytokinesis 1 -3.365
PMPCA peptidase (mitochondrial processing) alpha -3.2173
NELFB negative elongation factor complex member B -3.18395
TUBA4A tubulin, alpha 4a -3.1584
ACAA1 acetyl-CoA acyltransferase 1 -3.09495
RPS5 ribosomal protein S5 -3.0553
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.0403
FXYD5 FXYD domain containing ion transport regulator 5 -3.03385
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -2.937
KRT14 keratin 14, type I -2.87335
PGM1 phosphoglucomutase 1 -2.871
RGS2 regulator of G-protein signaling 2 -2.8698
FLG filaggrin -2.81265
CD81 CD81 molecule -2.81145
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.8025
KDM3A lysine (K)-specific demethylase 3A -2.782
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -2.72495
EIF3I eukaryotic translation initiation factor 3, subunit I -2.7205
SORD sorbitol dehydrogenase -2.71435
EDF1 endothelial differentiation-related factor 1 -2.69845
TMED9 transmembrane emp24 protein transport domain containing 9 -2.67867
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.66335
COQ4 coenzyme Q4 -2.66135
RRM2 ribonucleotide reductase M2 -2.65648
RABAC1 Rab acceptor 1 (prenylated) -2.6403
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -2.62805
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 -2.6247
RCC1 regulator of chromosome condensation 1 -2.58162
RAD23B RAD23 homolog B (S. cerevisiae) -2.56428
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.5475
TCHH trichohyalin -2.5438
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -2.54268
NOP10 NOP10 ribonucleoprotein -2.5094
EMC7 ER membrane protein complex subunit 7 -2.50575
GRWD1 glutamate-rich WD repeat containing 1 -2.4967
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 -2.47465
CRAT carnitine O-acetyltransferase -2.45958
ETHE1 ethylmalonic encephalopathy 1 -2.4469
ERP29 endoplasmic reticulum protein 29 -2.44235
CD34 CD34 molecule -2.43275
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -2.4314
MCOLN3 mucolipin 3 -2.408
SH3YL1 SH3 and SYLF domain containing 1 -2.39945
AGO1 argonaute RISC catalytic component 1 -2.3951
COTL1 coactosin-like F-actin binding protein 1 -2.38895
SPATA5L1 spermatogenesis associated 5-like 1 -2.38875
SYF2 SYF2 pre-mRNA-splicing factor -2.3761
TCP11L1 t-complex 11, testis-specific-like 1 -2.3639
RHOC ras homolog family member C -2.3334
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.3332
TOR1AIP2 torsin A interacting protein 2 -2.3327
CAPN2 calpain 2, (m/II) large subunit -2.32908
FOXD1 forkhead box D1 -2.31835
S100A7 S100 calcium binding protein A7 -2.3162
TMEM87A transmembrane protein 87A -2.31142
LAPTM4A lysosomal protein transmembrane 4 alpha -2.30315
PTCD3 pentatricopeptide repeat domain 3 -2.30285
PRRC2B proline-rich coiled-coil 2B -2.30203
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.29285
GYS1 glycogen synthase 1 (muscle) -2.2896
RPL18 ribosomal protein L18 -2.27455
REEP5 receptor accessory protein 5 -2.27362
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -2.26267
NME2 NME/NM23 nucleoside diphosphate kinase 2 -2.25675
GNG7 guanine nucleotide binding protein (G protein), gamma 7 -2.2544
DENR density-regulated protein -2.2471
MPV17L-BMERB1 MPV17L-BMERB1 readthrough -2.24625
MRPS15 mitochondrial ribosomal protein S15 -2.243
UBAC1 UBA domain containing 1 -2.2418
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.23095
MEMO1 mediator of cell motility 1 -2.22905
GGCT gamma-glutamylcyclotransferase -2.2178
NUP43 nucleoporin 43kDa -2.21245
XYLT1 xylosyltransferase I -2.21235
RCN1 reticulocalbin 1, EF-hand calcium binding domain -2.2122
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.2045
MFAP1 microfibrillar-associated protein 1 -2.2043
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -2.20295
JMJD7 jumonji domain containing 7 -2.1959
PTDSS1 phosphatidylserine synthase 1 -2.19205
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 -2.1908
HEXIM1 hexamethylene bis-acetamide inducible 1 -2.18895
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta -2.1879
ZBED1 zinc finger, BED-type containing 1 -2.1778
ASMTL acetylserotonin O-methyltransferase-like -2.1669
BMAL2 basic helix-loop-helix ARNT like 2 -2.1599
TUBB4B tubulin, beta 4B class IVb -2.15267
EEF2 eukaryotic translation elongation factor 2 -2.14322
TMEM147 transmembrane protein 147 -2.13635
TALDO1 transaldolase 1 -2.12245
PXMP4 peroxisomal membrane protein 4, 24kDa -2.1164
RNF11 ring finger protein 11 -2.1137
CCT8 chaperonin containing TCP1, subunit 8 (theta) -2.10765
CTSV cathepsin V -2.10345
UBE2S ubiquitin-conjugating enzyme E2S -2.09885
CDA cytidine deaminase -2.09625
AMOTL2 angiomotin like 2 -2.09495
QARS1 glutaminyl-tRNA synthetase 1 -2.09235
ATG14 autophagy related 14 -2.09015
TEX10 testis expressed 10 -2.08205
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -2.07905
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -2.078
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.07725
AOX1 aldehyde oxidase 1 -2.074
TYR tyrosinase -2.0732
PUM1 pumilio RNA-binding family member 1 -2.07
PPP6C protein phosphatase 6, catalytic subunit -2.06163
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -2.05957
ZWINT ZW10 interacting kinetochore protein -2.05835
IVD isovaleryl-CoA dehydrogenase -2.0437
TMEM208 transmembrane protein 208 -2.0343
PDLIM2 PDZ and LIM domain 2 (mystique) -2.0296
HARS1 histidyl-tRNA synthetase 1 -2.0294
ACSF2 acyl-CoA synthetase family member 2 -2.02835
PILRB paired immunoglobin-like type 2 receptor beta -2.0103
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -2.006
SRPX sushi-repeat containing protein, X-linked -2.0023