| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 5-(4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione 34.95 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
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154 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:B23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ELAC2 | elaC ribonuclease Z 2 | 5.95745 |
| NCK2 | NCK adaptor protein 2 | 4.9801 |
| STAP2 | signal transducing adaptor family member 2 | 4.9607 |
| MAMLD1 | mastermind-like domain containing 1 | 4.66275 |
| TESK1 | testis-specific kinase 1 | 3.43295 |
| HMGA2 | high mobility group AT-hook 2 | 3.30005 |
| TBPL1 | TBP-like 1 | 3.23845 |
| MMP2 | matrix metallopeptidase 2 | 3.1319 |
| ANAPC10 | anaphase promoting complex subunit 10 | 2.9923 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | 2.8843 |
| ZAP70 | zeta-chain (TCR) associated protein kinase 70kDa | 2.81065 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 2.786 |
| EGR1 | early growth response 1 | 2.77755 |
| OXSR1 | oxidative stress responsive 1 | 2.7649 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | 2.76205 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.7402 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 2.6901 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 2.68 |
| SPRY2 | sprouty homolog 2 (Drosophila) | 2.6624 |
| CRABP2 | cellular retinoic acid binding protein 2 | 2.65615 |
| GPC3 | glypican 3 | 2.6401 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 2.6185 |
| MTM1 | myotubularin 1 | 2.53327 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 2.5142 |
| LSM14B | LSM14B, SCD6 homolog B (S. cerevisiae) | 2.5096 |
| PUDP | pseudouridine 5'-phosphatase | 2.5079 |
| THBD | thrombomodulin | 2.50465 |
| UCKL1 | uridine-cytidine kinase 1-like 1 | 2.4823 |
| ECH1 | enoyl CoA hydratase 1, peroxisomal | 2.47975 |
| TTC19 | tetratricopeptide repeat domain 19 | 2.47365 |
| IL1B | interleukin 1, beta | 2.46443 |
| MAOB | monoamine oxidase B | 2.4622 |
| CLIC2 | chloride intracellular channel 2 | 2.4466 |
| CPB1 | carboxypeptidase B1 (tissue) | 2.40365 |
| TMEM267 | transmembrane protein 267 | 2.4017 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.39513 |
| HMGXB4 | HMG box domain containing 4 | 2.39012 |
| VAMP4 | vesicle-associated membrane protein 4 | 2.37908 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 2.33175 |
| LSM8 | LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 2.2914 |
| USP13 | ubiquitin specific peptidase 13 (isopeptidase T-3) | 2.28805 |
| SEPTIN10 | septin 10 | 2.28715 |
| RSF1 | remodeling and spacing factor 1 | 2.2533 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 2.2418 |
| KDM7A | lysine (K)-specific demethylase 7A | 2.2363 |
| SOWAHC | sosondowah ankyrin repeat domain family member C | 2.23575 |
| G0S2 | G0/G1 switch 2 | 2.23365 |
| RTN4 | reticulon 4 | 2.23045 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 2.2304 |
| MCFD2 | multiple coagulation factor deficiency 2 | 2.22802 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | 2.22622 |
| SNRNP27 | small nuclear ribonucleoprotein 27kDa (U4/U6.U5) | 2.21693 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 2.1995 |
| GPATCH2 | G patch domain containing 2 | 2.1808 |
| DGAT1 | diacylglycerol O-acyltransferase 1 | 2.1727 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 2.16645 |
| PRKRA | protein kinase, interferon-inducible double stranded RNA dependent activator | 2.16245 |
| IRS1 | insulin receptor substrate 1 | 2.16085 |
| ADAMTS3 | ADAM metallopeptidase with thrombospondin type 1 motif, 3 | 2.1438 |
| MFSD6 | major facilitator superfamily domain containing 6 | 2.1379 |
| RGPD1 | RANBP2-like and GRIP domain containing 1 | 2.1345 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | 2.13365 |
| CAMTA2 | calmodulin binding transcription activator 2 | 2.1216 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 2.10755 |
| PNKP | polynucleotide kinase 3'-phosphatase | 2.10505 |
| DUSP4 | dual specificity phosphatase 4 | 2.1044 |
| EOLA1 | endothelium and lymphocyte associated ASCH domain 1 | 2.09785 |
| SIN3B | SIN3 transcription regulator family member B | 2.09613 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 2.09253 |
| CLCC1 | chloride channel CLIC-like 1 | 2.06545 |
| UVRAG | UV radiation resistance associated | 2.0442 |
| CTSO | cathepsin O | 2.0388 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | 2.03845 |
| DVL1 | dishevelled segment polarity protein 1 | 2.03415 |
| DKK2 | dickkopf WNT signaling pathway inhibitor 2 | 2.02705 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.02435 |
| ZNF514 | zinc finger protein 514 | 2.01855 |
| NLRP4 | NLR family, pyrin domain containing 4 | 2.0171 |
| WAPL | WAPL cohesin release factor | 2.00533 |
| EEF1AKMT3 | EEF1A lysine methyltransferase 3 | 2.00005 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GADD45B | growth arrest and DNA-damage-inducible, beta | -6.94392 |
| COG4 | component of oligomeric golgi complex 4 | -5.8431 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -5.62595 |
| HOXA5 | homeobox A5 | -5.5799 |
| YARS2 | tyrosyl-tRNA synthetase 2, mitochondrial | -5.3346 |
| WASHC4 | WASH complex subunit 4 | -4.81773 |
| CCNB1 | cyclin B1 | -4.53245 |
| DNM1L | dynamin 1-like | -4.4176 |
| MRPS2 | mitochondrial ribosomal protein S2 | -4.17275 |
| PCNA | proliferating cell nuclear antigen | -4.12385 |
| GTPBP8 | GTP-binding protein 8 (putative) | -3.48035 |
| RPA3 | replication protein A3, 14kDa | -3.38875 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -3.18595 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -3.15972 |
| ASB6 | ankyrin repeat and SOCS box containing 6 | -3.1353 |
| COMMD9 | COMM domain containing 9 | -3.07825 |
| CD81 | CD81 molecule | -3.0249 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -2.94145 |
| HSPA1A | heat shock 70kDa protein 1A | -2.928 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -2.89925 |
| SNRNP25 | small nuclear ribonucleoprotein 25kDa (U11/U12) | -2.842 |
| C1QBP | complement component 1, q subcomponent binding protein | -2.7419 |
| COX6A1 | cytochrome c oxidase subunit VIa polypeptide 1 | -2.699 |
| DBNDD1 | dysbindin (dystrobrevin binding protein 1) domain containing 1 | -2.6031 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -2.5779 |
| ZSCAN5A | zinc finger and SCAN domain containing 5A | -2.519 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | -2.51045 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | -2.4826 |
| ATP8B4 | ATPase, class I, type 8B, member 4 | -2.46655 |
| FAIM | Fas apoptotic inhibitory molecule | -2.4413 |
| KIFC3 | kinesin family member C3 | -2.3843 |
| CTSF | cathepsin F | -2.37735 |
| CDS2 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 | -2.36855 |
| MISP | mitotic spindle positioning | -2.36305 |
| MTX1 | metaxin 1 | -2.343 |
| HOXA4 | homeobox A4 | -2.3418 |
| HOXA10-HOXA9 | HOXA10-HOXA9 readthrough | -2.3268 |
| UNG | uracil-DNA glycosylase | -2.3157 |
| MED21 | mediator complex subunit 21 | -2.29565 |
| TKT | transketolase | -2.29173 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -2.2696 |
| ABHD4 | abhydrolase domain containing 4 | -2.23055 |
| CD9 | CD9 molecule | -2.2248 |
| SLC39A1 | solute carrier family 39 (zinc transporter), member 1 | -2.22065 |
| ZFY | zinc finger protein, Y-linked | -2.21495 |
| R3HCC1 | R3H domain and coiled-coil containing 1 | -2.19495 |
| ILK | integrin-linked kinase | -2.18005 |
| SINHCAF | SIN3-HDAC complex associated factor | -2.17175 |
| TBK1 | TANK-binding kinase 1 | -2.15985 |
| INTS5 | integrator complex subunit 5 | -2.15705 |
| KIF3C | kinesin family member 3C | -2.15422 |
| USP5 | ubiquitin specific peptidase 5 (isopeptidase T) | -2.12065 |
| STMN1 | stathmin 1 | -2.11895 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -2.11455 |
| COTL1 | coactosin-like F-actin binding protein 1 | -2.11375 |
| TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | -2.09305 |
| TTC27 | tetratricopeptide repeat domain 27 | -2.0881 |
| ERP29 | endoplasmic reticulum protein 29 | -2.0828 |
| GNG3 | guanine nucleotide binding protein (G protein), gamma 3 | -2.06935 |
| PRR15L | proline rich 15-like | -2.06595 |
| ECSIT | ECSIT signalling integrator | -2.06005 |
| PSMB5 | proteasome (prosome, macropain) subunit, beta type, 5 | -2.05835 |
| RNF34 | ring finger protein 34, E3 ubiquitin protein ligase | -2.05425 |
| PYDC1 | PYD (pyrin domain) containing 1 | -2.05245 |
| MCM6 | minichromosome maintenance complex component 6 | -2.0494 |
| CAPRIN2 | caprin family member 2 | -2.0388 |
| CHCHD7 | coiled-coil-helix-coiled-coil-helix domain containing 7 | -2.025 |
| AKTIP | AKT interacting protein | -2.0248 |
| PHB1 | prohibitin 1 | -2.02415 |
| WDR74 | WD repeat domain 74 | -2.02067 |
| NABP2 | nucleic acid binding protein 2 | -2.01095 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | -2.00695 |
| FAIM2 | Fas apoptotic inhibitory molecule 2 | -2.00367 |
| BSCL2 | Berardinelli-Seip congenital lipodystrophy 2 (seipin) | -2.0026 |
