CRCGN015_MCF10A.TP53.M_24H:B24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-(4-{2-[methyl(2-pyridinyl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione 11.65 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

275 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:B24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 7.61152
KCTD5 potassium channel tetramerization domain containing 5 5.4354
CCP110 centriolar coiled coil protein 110kDa 4.97555
STIMATE STIM activating enhancer 4.80635
VGLL4 vestigial-like family member 4 4.67333
TMEM186 transmembrane protein 186 4.6152
DENND2D DENN/MADD domain containing 2D 4.5109
SPAG4 sperm associated antigen 4 4.4959
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.4863
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.34775
SNX11 sorting nexin 11 3.94435
TLCD3A TLC domain containing 3A 3.49365
GARRE1 granule associated Rac and RHOG effector 1 3.19965
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 3.19685
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 3.18695
TSPAN6 tetraspanin 6 3.10423
METTL22 methyltransferase like 22 3.09065
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 3.0856
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa 3.04525
CEPT1 choline/ethanolamine phosphotransferase 1 3.03505
CARHSP1 calcium regulated heat stable protein 1, 24kDa 2.9949
MCUR1 mitochondrial calcium uniporter regulator 1 2.97535
PYCR1 pyrroline-5-carboxylate reductase 1 2.9094
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.8018
TBPL1 TBP-like 1 2.75025
DEXI Dexi homolog (mouse) 2.7157
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.6932
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.6574
FIP1L1 factor interacting with PAPOLA and CPSF1 2.60975
HBA1 hemoglobin, alpha 1 2.59162
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.5508
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 2.5425
RWDD1 RWD domain containing 1 2.53685
NCOA6 nuclear receptor coactivator 6 2.5337
FRG1 FSHD region gene 1 2.5185
EIF1B eukaryotic translation initiation factor 1B 2.50915
BOLA2B bolA family member 2B 2.498
SCAF8 SR-related CTD-associated factor 8 2.4911
WIF1 WNT inhibitory factor 1 2.491
CINP cyclin-dependent kinase 2 interacting protein 2.48605
CNRIP1 cannabinoid receptor interacting protein 1 2.47
TCF12 transcription factor 12 2.45815
PNKP polynucleotide kinase 3'-phosphatase 2.4326
ELP5 elongator acetyltransferase complex subunit 5 2.4217
NELFA negative elongation factor complex member A 2.4215
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 2.42105
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 2.4125
INPP1 inositol polyphosphate-1-phosphatase 2.40185
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 2.39455
SAP30 Sin3A-associated protein, 30kDa 2.3818
MOK MOK protein kinase 2.37015
ECH1 enoyl CoA hydratase 1, peroxisomal 2.3605
MED28 mediator complex subunit 28 2.35915
EMP2 epithelial membrane protein 2 2.3221
ATP5ME ATP synthase membrane subunit e 2.31532
ASTE1 asteroid homolog 1 (Drosophila) 2.3115
UTP11 UTP11 small subunit processome component 2.29645
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.2903
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 2.2809
MOB4 MOB family member 4, phocein 2.28038
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 2.2666
MMP1 matrix metallopeptidase 1 2.26358
MPZL1 myelin protein zero-like 1 2.25836
MRPL18 mitochondrial ribosomal protein L18 2.25835
TFB1M transcription factor B1, mitochondrial 2.25065
AGR2 anterior gradient 2 2.24435
REV1 REV1, polymerase (DNA directed) 2.22875
EXOSC4 exosome component 4 2.20965
SRSF4 serine/arginine-rich splicing factor 4 2.20145
PLSCR3 phospholipid scramblase 3 2.1995
TMEM11 transmembrane protein 11 2.197
HAPSTR1 HUWE1 associated protein modifying stress responses 2.1918
MARK3 MAP/microtubule affinity-regulating kinase 3 2.17705
CEP76 centrosomal protein 76kDa 2.1743
RBM22 RNA binding motif protein 22 2.15805
NARS1 asparaginyl-tRNA synthetase 1 2.1549
MYO5C myosin VC 2.154
CYFIP1 cytoplasmic FMR1 interacting protein 1 2.15375
EMC8 ER membrane protein complex subunit 8 2.14135
HSPA4L heat shock 70kDa protein 4-like 2.13205
JAM3 junctional adhesion molecule 3 2.12455
BLMH bleomycin hydrolase 2.12055
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.1203
BLVRA biliverdin reductase A 2.1123
TRAF3 TNF receptor-associated factor 3 2.10285
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.08245
EVA1B eva-1 homolog B (C. elegans) 2.08055
XPO6 exportin 6 2.07425
PAGR1 PAXIP1 associated glutamate-rich protein 1 2.0731
BEX2 brain expressed X-linked 2 2.0726
NPIPB5 nuclear pore complex interacting protein family, member B5 2.06365
GMPPB GDP-mannose pyrophosphorylase B 2.04835
FHL2 four and a half LIM domains 2 2.0482
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.04225
CPM carboxypeptidase M 2.04205
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 2.0332
CHMP2A charged multivesicular body protein 2A 2.0132
SNRPF small nuclear ribonucleoprotein polypeptide F 2.00535

decreased expression

Symbol Name Standardized Value
DYNLT3 dynein, light chain, Tctex-type 3 -5.23745
CCNB1 cyclin B1 -5.21455
ATF5 activating transcription factor 5 -4.8428
KRT14 keratin 14, type I -4.6081
SLC35F2 solute carrier family 35, member F2 -4.52575
ACOT9 acyl-CoA thioesterase 9 -4.229
MRPS2 mitochondrial ribosomal protein S2 -3.90745
PTK2 protein tyrosine kinase 2 -3.68702
MED22 mediator complex subunit 22 -3.62915
CAPN2 calpain 2, (m/II) large subunit -3.42967
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -3.2419
PAEP progestagen-associated endometrial protein -3.07235
PRDX4 peroxiredoxin 4 -3.05415
RGS2 regulator of G-protein signaling 2 -2.9157
SLC14A2 solute carrier family 14 (urea transporter), member 2 -2.8962
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) -2.79905
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.798
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 -2.7938
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 -2.7676
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 -2.7625
CLCNKA chloride channel, voltage-sensitive Ka -2.7444
C1QBP complement component 1, q subcomponent binding protein -2.7003
LOC127933115 uncharacterized LOC127933115 -2.69855
COQ4 coenzyme Q4 -2.6956
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.673
CAVIN3 caveolae associated protein 3 -2.66755
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled -2.65845
CASQ2 calsequestrin 2 (cardiac muscle) -2.64985
ATF3 activating transcription factor 3 -2.6452
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.64218
ACKR5 atypical chemokine receptor 5 -2.64175
KRT38 keratin 38, type I -2.63675
NMRK1 nicotinamide riboside kinase 1 -2.62985
RFPL3 ret finger protein-like 3 -2.6271
BFSP2 beaded filament structural protein 2, phakinin -2.58725
CSDC2 cold shock domain containing C2, RNA binding -2.58245
GFRA4 GDNF family receptor alpha 4 -2.5728
STAB2 stabilin 2 -2.55715
KRT76 keratin 76, type II -2.55305
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 -2.54535
FTCD formimidoyltransferase cyclodeaminase -2.54395
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.5427
PRCP prolylcarboxypeptidase (angiotensinase C) -2.5351
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene) -2.50625
RNF208 ring finger protein 208 -2.4713
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 -2.44985
EYA4 EYA transcriptional coactivator and phosphatase 4 -2.4239
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -2.417
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7 -2.41633
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 -2.4154
TRPV5 transient receptor potential cation channel, subfamily V, member 5 -2.41365
MAPK8 mitogen-activated protein kinase 8 -2.41218
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 -2.4075
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 -2.4042
GRWD1 glutamate-rich WD repeat containing 1 -2.3952
SLC17A4 solute carrier family 17, member 4 -2.39145
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -2.3842
ATL2 atlastin GTPase 2 -2.37635
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 -2.37433
FOXL1 forkhead box L1 -2.37315
OLFML2A olfactomedin-like 2A -2.36155
VAV1 vav 1 guanine nucleotide exchange factor -2.3561
PPP1R13L protein phosphatase 1, regulatory subunit 13 like -2.35365
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.3354
GLRA2 glycine receptor, alpha 2 -2.32095
CA14 carbonic anhydrase XIV -2.3191
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) -2.3163
IFNA13 interferon, alpha 13 -2.30735
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 -2.29925
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.2938
PTPN7 protein tyrosine phosphatase, non-receptor type 7 -2.2889
BASP1 brain abundant, membrane attached signal protein 1 -2.28785
APOO apolipoprotein O -2.28465
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -2.2832
KLHL35 kelch-like family member 35 -2.27565
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) -2.2712
DENND1C DENN/MADD domain containing 1C -2.26945
ATP11B ATPase, class VI, type 11B -2.2691
THUMPD2 THUMP domain containing 2 -2.2638
PRKG2 protein kinase, cGMP-dependent, type II -2.2557
ERN1 endoplasmic reticulum to nucleus signaling 1 -2.25285
IQCE IQ motif containing E -2.24825
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -2.2431
ACADL acyl-CoA dehydrogenase, long chain -2.2374
TSPOAP1 TSPO associated protein 1 -2.23305
BIN2 bridging integrator 2 -2.22945
RAP1GAP2 RAP1 GTPase activating protein 2 -2.228
PBLD phenazine biosynthesis-like protein domain containing -2.22645
GABARAPL1 GABA(A) receptor-associated protein like 1 -2.22577
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -2.22355
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 -2.21125
CRHBP corticotropin releasing hormone binding protein -2.2075
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 -2.20025
PDE1B phosphodiesterase 1B, calmodulin-dependent -2.1906
NME8 NME/NM23 family member 8 -2.1852
GCGR glucagon receptor -2.18135
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -2.17085
CHAD chondroadherin -2.1669
CDC37L1 cell division cycle 37-like 1 -2.16005
TRPM6 transient receptor potential cation channel, subfamily M, member 6 -2.1583
ASS1 argininosuccinate synthase 1 -2.15385
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 -2.1456
GFI1B growth factor independent 1B transcription repressor -2.14435
KRT8 keratin 8, type II -2.14155
YPEL5 yippee-like 5 (Drosophila) -2.1407
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -2.1339
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled -2.13285
IFNA21 interferon, alpha 21 -2.1327
ATXN10 ataxin 10 -2.12385
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -2.123
AKR1D1 aldo-keto reductase family 1, member D1 -2.1228
OTC ornithine carbamoyltransferase -2.11995
SLC38A10 solute carrier family 38, member 10 -2.11945
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -2.11925
TSC1 tuberous sclerosis 1 -2.11835
CSRP1 cysteine and glycine-rich protein 1 -2.10873
SYT2 synaptotagmin II -2.10825
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.1049
OGDHL oxoglutarate dehydrogenase-like -2.10005
CBX2 chromobox homolog 2 -2.0987
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 -2.09705
ZNF507 zinc finger protein 507 -2.09655
OR7C2 olfactory receptor, family 7, subfamily C, member 2 -2.09495
NELFB negative elongation factor complex member B -2.09425
IDO1 indoleamine 2,3-dioxygenase 1 -2.09345
WDR55 WD repeat domain 55 -2.09267
TLR6 toll-like receptor 6 -2.09155
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic -2.09013
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -2.0854
LUZP4 leucine zipper protein 4 -2.08465
DNAH3 dynein, axonemal, heavy chain 3 -2.0827
TTLL7 tubulin tyrosine ligase-like family member 7 -2.07885
VNN1 vanin 1 -2.078
CYTH4 cytohesin 4 -2.0744
GJD2 gap junction protein, delta 2, 36kDa -2.07405
NTN1 netrin 1 -2.07255
PTPRT protein tyrosine phosphatase, receptor type, T -2.0716
CHRM2 cholinergic receptor, muscarinic 2 -2.0706
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) -2.069
GBX1 gastrulation brain homeobox 1 -2.06725
IGFBP7 insulin-like growth factor binding protein 7 -2.05985
NQO2 NAD(P)H dehydrogenase, quinone 2 -2.05205
FLRT3 fibronectin leucine rich transmembrane protein 3 -2.0493
SARS2 seryl-tRNA synthetase 2, mitochondrial -2.04505
ZC4H2 zinc finger, C4H2 domain containing -2.0433
CTRL chymotrypsin-like -2.0404
DIPK2B divergent protein kinase domain 2B -2.03805
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 -2.03805
ZNF318 zinc finger protein 318 -2.03795
ZMAT4 zinc finger, matrin-type 4 -2.0367
ZFR2 zinc finger RNA binding protein 2 -2.03225
GOLT1A golgi transport 1A -2.0317
MED31 mediator complex subunit 31 -2.0312
CUBN cubilin (intrinsic factor-cobalamin receptor) -2.0303
CNPY3-GNMT CNPY3-GNMT readthrough -2.02835
PLK2 polo-like kinase 2 -2.02785
RAB3D RAB3D, member RAS oncogene family -2.02435
UPB1 ureidopropionase, beta -2.02355
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 -2.02323
CFAP74 cilia and flagella associated protein 74 -2.023
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -2.02175
FAN1 FANCD2/FANCI-associated nuclease 1 -2.0214
TTLL1 tubulin tyrosine ligase-like family member 1 -2.0208
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 -2.0208
PRRC2B proline-rich coiled-coil 2B -2.01655
HAO2 hydroxyacid oxidase 2 (long chain) -2.01505
SEC16A SEC16 homolog A (S. cerevisiae) -2.0132
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.00995
SLC38A2 solute carrier family 38, member 2 -2.00988
LY9 lymphocyte antigen 9 -2.00987
MYO1F myosin IF -2.0097
SAMD4A sterile alpha motif domain containing 4A -2.00848
PLEKHA6 pleckstrin homology domain containing, family A member 6 -2.007
PZP pregnancy-zone protein -2.00535
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) -2.00405
CLCNKB chloride channel, voltage-sensitive Kb -2.00115
ASCL3 achaete-scute family bHLH transcription factor 3 -2.00055