CRCGN015_MCF10A.TP53.M_24H:C01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tryptamine 100.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

97 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:C01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 7.24167
CNRIP1 cannabinoid receptor interacting protein 1 4.43965
STMN2 stathmin 2 4.18304
NUCB2 nucleobindin 2 4.0935
MAMLD1 mastermind-like domain containing 1 3.88192
BID BH3 interacting domain death agonist 3.26446
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.22472
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.13273
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.08475
SEZ6L seizure related 6 homolog (mouse)-like 3.07847
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 3.06272
NSG2 neuronal vesicle trafficking associated 2 3.01268
SNAP91 synaptosomal-associated protein, 91kDa 2.99089
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.97709
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.90837
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.85936
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.83529
TAGLN3 transgelin 3 2.81346
RPH3A rabphilin 3A 2.80289
CARTPT CART prepropeptide 2.77736
TAC1 tachykinin, precursor 1 2.76941
SYN1 synapsin I 2.73108
CHGB chromogranin B 2.67744
BEX2 brain expressed X-linked 2 2.67511
GNG4 guanine nucleotide binding protein (G protein), gamma 4 2.65338
VGLL4 vestigial-like family member 4 2.60171
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.58396
RUNDC3A RUN domain containing 3A 2.58222
ACTL6B actin-like 6B 2.53191
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.48079
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.47809
SCG2 secretogranin II 2.4182
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 2.41353
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.3796
INA internexin neuronal intermediate filament protein, alpha 2.37102
SYT1 synaptotagmin I 2.36044
TCTN1 tectonic family member 1 2.35454
SV2C synaptic vesicle glycoprotein 2C 2.34518
PDYN prodynorphin 2.33682
INSIG1 insulin induced gene 1 2.33088
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.32343
SCG3 secretogranin III 2.31616
ASPHD1 aspartate beta-hydroxylase domain containing 1 2.31532
SV2B synaptic vesicle glycoprotein 2B 2.29876
SNCB synuclein, beta 2.29392
PCSK2 proprotein convertase subtilisin/kexin type 2 2.26322
TMEM35A transmembrane protein 35A 2.22302
RFPL2 ret finger protein-like 2 2.21948
NGFR nerve growth factor receptor 2.21267
NEUROD1 neuronal differentiation 1 2.19088
TRIB3 tribbles pseudokinase 3 2.15323
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.15083
NEFL neurofilament, light polypeptide 2.13112
MTM1 myotubularin 1 2.1276
FRRS1L ferric-chelate reductase 1-like 2.12607
SCN1B sodium channel, voltage gated, type I beta subunit 2.11762
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 2.09512
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.08769
CPE carboxypeptidase E 2.08191
HMOX1 heme oxygenase 1 2.07411
PRSS58 protease, serine, 58 2.06612
RAB6B RAB6B, member RAS oncogene family 2.06002
MOSPD1 motile sperm domain containing 1 2.04309
AP3B2 adaptor-related protein complex 3, beta 2 subunit 2.0427
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 2.04021
SH3GL2 SH3-domain GRB2-like 2 2.03843
REEP1 receptor accessory protein 1 2.03731
PJA1 praja ring finger 1, E3 ubiquitin protein ligase 2.02602
FGF14 fibroblast growth factor 14 2.01126

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.54382
ACOT9 acyl-CoA thioesterase 9 -4.36482
TNIP1 TNFAIP3 interacting protein 1 -4.21823
MRPS2 mitochondrial ribosomal protein S2 -3.93657
ATF5 activating transcription factor 5 -3.80329
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.50335
CD58 CD58 molecule -3.16363
RPA3 replication protein A3, 14kDa -2.93453
NT5DC2 5'-nucleotidase domain containing 2 -2.89487
BAG3 BCL2-associated athanogene 3 -2.82466
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.65362
COTL1 coactosin-like F-actin binding protein 1 -2.64719
PNKP polynucleotide kinase 3'-phosphatase -2.57805
MRPL19 mitochondrial ribosomal protein L19 -2.51688
MTERF3 mitochondrial transcription termination factor 3 -2.46318
UFM1 ubiquitin-fold modifier 1 -2.46217
NPDC1 neural proliferation, differentiation and control, 1 -2.44393
IPO13 importin 13 -2.35366
PLSCR3 phospholipid scramblase 3 -2.31723
CHPT1 choline phosphotransferase 1 -2.24894
PARP1 poly (ADP-ribose) polymerase 1 -2.20157
ZNF274 zinc finger protein 274 -2.1489
TRAPPC3 trafficking protein particle complex 3 -2.14171
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.08868
KNTC1 kinetochore associated 1 -2.07468
UNG uracil-DNA glycosylase -2.04147
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.02298
GLT8D1 glycosyltransferase 8 domain containing 1 -2.01637