CRCGN015_MCF10A.TP53.M_24H:C06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tranilast 11.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

28 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:C06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 4.11292
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.80151
SQOR sulfide quinone oxidoreductase 3.74723
BAMBI BMP and activin membrane-bound inhibitor 3.49455
CCDC92 coiled-coil domain containing 92 3.06213
SPAG4 sperm associated antigen 4 3.04019
ADAM10 ADAM metallopeptidase domain 10 3.03931
BID BH3 interacting domain death agonist 2.92224
NOTCH1 notch 1 2.77199
CCL2 chemokine (C-C motif) ligand 2 2.44114
CAPN1 calpain 1, (mu/I) large subunit 2.36501
SCAND1 SCAN domain containing 1 2.21071
PECR peroxisomal trans-2-enoyl-CoA reductase 2.14656

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -5.93137
CCNB2 cyclin B2 -4.13626
TIMP1 TIMP metallopeptidase inhibitor 1 -3.721
RPIA ribose 5-phosphate isomerase A -3.57179
MTERF3 mitochondrial transcription termination factor 3 -3.28693
NT5DC2 5'-nucleotidase domain containing 2 -2.91545
KDM3A lysine (K)-specific demethylase 3A -2.53248
PCNA proliferating cell nuclear antigen -2.52916
CD58 CD58 molecule -2.47653
ACAA1 acetyl-CoA acyltransferase 1 -2.31498
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.25861
CCNB1 cyclin B1 -2.2373
RAD51C RAD51 paralog C -2.10812
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.08356
SGK1 serum/glucocorticoid regulated kinase 1 -2.05935