CRCGN015_MCF10A.TP53.M_24H:C08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 15-delta-prostaglandin-j2 0.67 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

222 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:C08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 9.23165
TXNRD1 thioredoxin reductase 1 6.85155
ABHD4 abhydrolase domain containing 4 6.17265
UGDH UDP-glucose 6-dehydrogenase 6.10015
CARMIL1 capping protein regulator and myosin 1 linker 1 5.2663
SPAG4 sperm associated antigen 4 5.1051
CNPY3 canopy FGF signaling regulator 3 4.48525
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.4045
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 4.21445
SQOR sulfide quinone oxidoreductase 4.11315
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.7686
CTSL cathepsin L 3.71945
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.7029
NUCB2 nucleobindin 2 3.57125
GSR glutathione reductase 3.55615
SQSTM1 sequestosome 1 3.42793
SNF8 SNF8, ESCRT-II complex subunit 3.3716
TSKU tsukushi, small leucine rich proteoglycan 3.3448
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 3.27075
GCLM glutamate-cysteine ligase, modifier subunit 3.25605
BAMBI BMP and activin membrane-bound inhibitor 3.21125
NQO1 NAD(P)H dehydrogenase, quinone 1 3.13437
NADSYN1 NAD synthetase 1 2.9893
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.90745
ZMAT5 zinc finger, matrin-type 5 2.8632
PIR pirin (iron-binding nuclear protein) 2.8136
NOL7 nucleolar protein 7, 27kDa 2.74407
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 2.73973
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.6769
STK10 serine/threonine kinase 10 2.65202
CTSZ cathepsin Z 2.6412
LASP1 LIM and SH3 protein 1 2.51825
CANT1 calcium activated nucleotidase 1 2.48395
MCUR1 mitochondrial calcium uniporter regulator 1 2.46075
AKR1C3 aldo-keto reductase family 1, member C3 2.4433
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 2.43175
ETFB electron-transfer-flavoprotein, beta polypeptide 2.4314
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 2.4152
ALAS1 5'-aminolevulinate synthase 1 2.41235
SPA17 sperm autoantigenic protein 17 2.40215
KLHDC2 kelch domain containing 2 2.32455
AARSD1 alanyl-tRNA synthetase domain containing 1 2.32275
TRIM16 tripartite motif containing 16 2.32
PAMR1 peptidase domain containing associated with muscle regeneration 1 2.31475
LRRN3 leucine rich repeat neuronal 3 2.29717
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 2.28172
RABL3 RAB, member of RAS oncogene family-like 3 2.2798
TIMP4 TIMP metallopeptidase inhibitor 4 2.2651
SATB1 SATB homeobox 1 2.26325
CES1 carboxylesterase 1 2.2319
MTCH1 mitochondrial carrier 1 2.2238
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.20295
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.1717
LRP10 low density lipoprotein receptor-related protein 10 2.13165
CHMP2B charged multivesicular body protein 2B 2.11307
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 2.1089
GLRX glutaredoxin (thioltransferase) 2.10882
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.09685
RTN3 reticulon 3 2.0752
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.0653
CD248 CD248 molecule, endosialin 2.05755
COPB1 coatomer protein complex, subunit beta 1 2.04618
PPIB peptidylprolyl isomerase B (cyclophilin B) 2.0461
SMAP1 small ArfGAP 1 2.04025
PRR13 proline rich 13 2.0316
TDG thymine-DNA glycosylase 2.027
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.01685
ARCN1 archain 1 2.0138
FTH1 ferritin, heavy polypeptide 1 2.01113
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 2.0089
IFI35 interferon-induced protein 35 2.0041

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -8.8427
HMG20B high mobility group 20B -5.6037
MRPS2 mitochondrial ribosomal protein S2 -4.9808
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.77955
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.4682
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -4.40805
ARPP19 cAMP-regulated phosphoprotein, 19kDa -4.00277
VDAC1 voltage-dependent anion channel 1 -3.91812
ANKRD10 ankyrin repeat domain 10 -3.71995
MTERF3 mitochondrial transcription termination factor 3 -3.7171
HMOX2 heme oxygenase 2 -3.57917
TMEM186 transmembrane protein 186 -3.5318
RALGDS ral guanine nucleotide dissociation stimulator -3.44032
ZNF146 zinc finger protein 146 -3.27435
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -3.25285
UBA2 ubiquitin-like modifier activating enzyme 2 -3.24325
ZNF263 zinc finger protein 263 -3.23555
KIF18B kinesin family member 18B -3.23465
TBCB tubulin folding cofactor B -3.13222
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.06502
PIGG phosphatidylinositol glycan anchor biosynthesis, class G -3.00065
RAD51C RAD51 paralog C -2.92873
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.9216
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.84455
TMEM147 transmembrane protein 147 -2.8423
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 -2.77952
ATP5ME ATP synthase membrane subunit e -2.7423
UBN1 ubinuclein 1 -2.73933
MRPS27 mitochondrial ribosomal protein S27 -2.7375
BFAR bifunctional apoptosis regulator -2.70695
CA2 carbonic anhydrase II -2.6892
PARP16 poly (ADP-ribose) polymerase family, member 16 -2.6779
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.6751
CASP8AP2 caspase 8 associated protein 2 -2.6564
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.647
CRBN cereblon -2.6012
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 -2.5941
LRRC31 leucine rich repeat containing 31 -2.57105
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 -2.54065
STMN1 stathmin 1 -2.53225
CXCL12 chemokine (C-X-C motif) ligand 12 -2.51638
WDR62 WD repeat domain 62 -2.5108
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -2.5026
GRWD1 glutamate-rich WD repeat containing 1 -2.4865
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha -2.483
FHIT fragile histidine triad -2.4824
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -2.46718
SOX11 SRY (sex determining region Y)-box 11 -2.46652
WDR4 WD repeat domain 4 -2.4558
FKBP1B FK506 binding protein 1B, 12.6 kDa -2.44817
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.44545
STOM stomatin -2.4335
AQP1 aquaporin 1 (Colton blood group) -2.42462
DEXI Dexi homolog (mouse) -2.42255
RBM12B RNA binding motif protein 12B -2.4127
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.40525
ZNF768 zinc finger protein 768 -2.39425
CCNL2 cyclin L2 -2.39235
RNF40 ring finger protein 40, E3 ubiquitin protein ligase -2.37855
DDN dendrin -2.3709
PUM1 pumilio RNA-binding family member 1 -2.36495
CACTIN cactin, spliceosome C complex subunit -2.36143
PROX1 prospero homeobox 1 -2.3498
LMO3 LIM domain only 3 (rhombotin-like 2) -2.34755
ANAPC2 anaphase promoting complex subunit 2 -2.3475
PYGB phosphorylase, glycogen; brain -2.34485
ENO3 enolase 3 (beta, muscle) -2.34285
NPIPB5 nuclear pore complex interacting protein family, member B5 -2.33505
CDKN2AIP CDKN2A interacting protein -2.3325
SNX6 sorting nexin 6 -2.31485
SORBS3 sorbin and SH3 domain containing 3 -2.31157
MEX3D mex-3 RNA binding family member D -2.3009
PILRB paired immunoglobin-like type 2 receptor beta -2.2982
NPY neuropeptide Y -2.29705
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa -2.297
DVL1 dishevelled segment polarity protein 1 -2.29685
LCAT lecithin-cholesterol acyltransferase -2.2968
ART3 ADP-ribosyltransferase 3 -2.28855
C8A complement component 8, alpha polypeptide -2.2837
NOP14 NOP14 nucleolar protein -2.26985
SPTSSA serine palmitoyltransferase, small subunit A -2.26008
MBL2 mannose-binding lectin (protein C) 2, soluble -2.2568
MPHOSPH8 M-phase phosphoprotein 8 -2.2537
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -2.25297
LUM lumican -2.24985
GPATCH1 G patch domain containing 1 -2.2481
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type -2.23665
ZZZ3 zinc finger, ZZ-type containing 3 -2.2352
MFN2 mitofusin 2 -2.22925
HAUS3 HAUS augmin-like complex, subunit 3 -2.22545
CRLF1 cytokine receptor-like factor 1 -2.2237
RCL1 RNA terminal phosphate cyclase-like 1 -2.2231
NDC1 NDC1 transmembrane nucleoporin -2.22165
PLPP6 phospholipid phosphatase 6 -2.2205
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.21668
OXCT1 3-oxoacid CoA transferase 1 -2.2146
MAEA macrophage erythroblast attacher -2.21225
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -2.2085
ALLC allantoicase -2.20335
CBR4 carbonyl reductase 4 -2.19265
ZNF500 zinc finger protein 500 -2.19202
NUP43 nucleoporin 43kDa -2.1916
POGZ pogo transposable element with ZNF domain -2.19143
AUH AU RNA binding protein/enoyl-CoA hydratase -2.18575
RNF130 ring finger protein 130 -2.176
RYR1 ryanodine receptor 1 (skeletal) -2.17265
CLIC4 chloride intracellular channel 4 -2.17053
ANKRD46 ankyrin repeat domain 46 -2.16725
CRIP2 cysteine-rich protein 2 -2.16525
GPR171 G protein-coupled receptor 171 -2.1563
GALP galanin-like peptide -2.15405
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) -2.14905
NPY1R neuropeptide Y receptor Y1 -2.14585
PTGDR prostaglandin D2 receptor (DP) -2.14475
CRYZ crystallin, zeta (quinone reductase) -2.14235
HBD hemoglobin, delta -2.14035
EPHA4 EPH receptor A4 -2.13985
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -2.13867
CACFD1 calcium channel flower domain containing 1 -2.13153
RAD50 RAD50 homolog (S. cerevisiae) -2.12535
TMA16 translation machinery associated 16 homolog (S. cerevisiae) -2.1185
LECT2 leukocyte cell-derived chemotaxin 2 -2.1174
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) -2.11165
GEMIN6 gem (nuclear organelle) associated protein 6 -2.10915
MTFR1 mitochondrial fission regulator 1 -2.092
AKAP1 A kinase (PRKA) anchor protein 1 -2.09184
TNIK TRAF2 and NCK interacting kinase -2.08972
GSTCD glutathione S-transferase, C-terminal domain containing -2.0893
ARPP21 cAMP-regulated phosphoprotein, 21kDa -2.08785
MUL1 mitochondrial E3 ubiquitin protein ligase 1 -2.08575
CDC25B cell division cycle 25B -2.084
IVL involucrin -2.0752
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.0718
DEFA3 defensin, alpha 3, neutrophil-specific -2.068
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 -2.06355
CAPNS1 calpain, small subunit 1 -2.06015
CLSTN3 calsyntenin 3 -2.05915
TSC1 tuberous sclerosis 1 -2.0541
RPL36A ribosomal protein L36a -2.0513
FPGT fucose-1-phosphate guanylyltransferase -2.0493
PEF1 penta-EF-hand domain containing 1 -2.04165
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 -2.03585
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.03455
NR1H4 nuclear receptor subfamily 1, group H, member 4 -2.02785
BET1 Bet1 golgi vesicular membrane trafficking protein -2.02365
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase -2.0146
F9 coagulation factor IX -2.01415
NMU neuromedin U -2.0133
TMPRSS11E transmembrane protease, serine 11E -2.01175
PARP6 poly (ADP-ribose) polymerase family, member 6 -2.00655
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -2.00235