CRCGN015_MCF10A.TP53.M_24H:C10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cimetidine 99.96 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 6.32635
ABHD6 abhydrolase domain containing 6 4.97627
KLHL9 kelch-like family member 9 4.2271
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.1799
TBX2 T-box 2 4.11168
HBB hemoglobin, beta 4.0144
ACAA1 acetyl-CoA acyltransferase 1 3.59963
HBA1 hemoglobin, alpha 1 2.92836
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.58015
TSKU tsukushi, small leucine rich proteoglycan 2.4144
DNASE1L3 deoxyribonuclease I-like 3 2.38875
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.2699
TMEM242 transmembrane protein 242 2.23315
AKR1D1 aldo-keto reductase family 1, member D1 2.22615
GSTZ1 glutathione S-transferase zeta 1 2.1587
PPIF peptidylprolyl isomerase F 2.12993
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2.1205
VILL villin-like 2.117
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.11
ATMIN ATM interactor 2.08827
ZNF222 zinc finger protein 222 2.0777
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 2.02218

decreased expression

Symbol Name Standardized Value
TRAPPC3 trafficking protein particle complex 3 -5.34962
TSPAN4 tetraspanin 4 -5.15728
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -4.48995
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.59388
BASP1 brain abundant, membrane attached signal protein 1 -3.0547
MEAF6 MYST/Esa1-associated factor 6 -2.834
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.76653
NGRN neugrin, neurite outgrowth associated -2.73105
ZMYM4 zinc finger, MYM-type 4 -2.40223
ANKRD10 ankyrin repeat domain 10 -2.2379
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -2.21718
IGFBP7 insulin-like growth factor binding protein 7 -2.20607
AGO1 argonaute RISC catalytic component 1 -2.1315
NPDC1 neural proliferation, differentiation and control, 1 -2.10335
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -2.0466
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -2.01402