CRCGN015_MCF10A.TP53.M_24H:C11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cimetidine 33.32 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

79 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:C11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 5.6632
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.218
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.70625
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.62045
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.22007
AGR2 anterior gradient 2 2.9455
MMP1 matrix metallopeptidase 1 2.80623
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 2.6431
ZNF22 zinc finger protein 22 2.57705
GRB7 growth factor receptor-bound protein 7 2.5445
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 2.539
CD1B CD1b molecule 2.5211
CGRRF1 cell growth regulator with ring finger domain 1 2.4975
ZNF180 zinc finger protein 180 2.47015
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.42015
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.418
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.41565
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.35045
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.3363
MAMLD1 mastermind-like domain containing 1 2.3033
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 2.2983
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 2.2914
ZNF32 zinc finger protein 32 2.2731
WDR3 WD repeat domain 3 2.2727
RLN1 relaxin 1 2.22365
BRD9 bromodomain containing 9 2.21885
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.21845
HAT1 histone acetyltransferase 1 2.2148
USB1 U6 snRNA biogenesis 1 2.21195
ZNF250 zinc finger protein 250 2.1949
TASL TLR adaptor interacting with endolysosomal SLC15A4 2.18505
ZNF197 zinc finger protein 197 2.14935
CCRL2 chemokine (C-C motif) receptor-like 2 2.14915
GTF2B general transcription factor IIB 2.1475
LRRC8B leucine rich repeat containing 8 family, member B 2.1471
NUP155 nucleoporin 155kDa 2.1377
MON1B MON1 secretory trafficking family member B 2.13285
ZNF45 zinc finger protein 45 2.11702
TBC1D31 TBC1 domain family, member 31 2.11345
ZFYVE16 zinc finger, FYVE domain containing 16 2.10845
MAGEH1 melanoma antigen family H1 2.09065
SLC26A3 solute carrier family 26 (anion exchanger), member 3 2.0619
SPDEF SAM pointed domain containing ETS transcription factor 2.0562
MAGEA11 melanoma antigen family A11 2.0057
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.0034

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -5.7988
COG2 component of oligomeric golgi complex 2 -5.0741
UFM1 ubiquitin-fold modifier 1 -4.84275
PCNA proliferating cell nuclear antigen -4.38165
TUBA4A tubulin, alpha 4a -4.00275
LYPLA1 lysophospholipase I -3.83413
CANT1 calcium activated nucleotidase 1 -3.77155
ANKRD10 ankyrin repeat domain 10 -3.2905
TRAP1 TNF receptor-associated protein 1 -2.9729
PCCB propionyl CoA carboxylase, beta polypeptide -2.83965
TBC1D16 TBC1 domain family, member 16 -2.72995
HSPA1A heat shock 70kDa protein 1A -2.6011
SUMO4 small ubiquitin-like modifier 4 -2.3123
PERP PERP, TP53 apoptosis effector -2.2357
MGST2 microsomal glutathione S-transferase 2 -2.2172
ACTN4 actinin, alpha 4 -2.21425
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.17855
MSX1 msh homeobox 1 -2.16415
IGF2R insulin-like growth factor 2 receptor -2.1622
HEATR1 HEAT repeat containing 1 -2.13685
MRPS2 mitochondrial ribosomal protein S2 -2.112
DRG2 developmentally regulated GTP binding protein 2 -2.10605
SORBS3 sorbin and SH3 domain containing 3 -2.09312
GAK cyclin G associated kinase -2.09183
NISCH nischarin -2.07625
COTL1 coactosin-like F-actin binding protein 1 -2.07555
TOB1 transducer of ERBB2, 1 -2.0728
TMEM230 transmembrane protein 230 -2.05835
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.05072
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) -2.03435
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.0205
EYA2 EYA transcriptional coactivator and phosphatase 2 -2.01905
MRPL15 mitochondrial ribosomal protein L15 -2.01495
SEC16A SEC16 homolog A (S. cerevisiae) -2.00305