CRCGN015_MCF10A.TP53.M_24H:C13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxyquinoline 101.47 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

130 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:C13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STAP2 signal transducing adaptor family member 2 5.08085
E2F2 E2F transcription factor 2 4.8779
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.76895
AMDHD2 amidohydrolase domain containing 2 4.47995
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 4.03255
ACAA1 acetyl-CoA acyltransferase 1 3.76585
ADGRB1 adhesion G protein-coupled receptor B1 3.30615
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.15128
LHX5 LIM homeobox 5 3.0556
PRMT7 protein arginine methyltransferase 7 3.01145
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.9945
PRM2 protamine 2 2.9846
MTA2 metastasis associated 1 family, member 2 2.9729
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.87235
PRDM8 PR domain containing 8 2.83575
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.8288
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 2.80055
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.65395
SSTR5 somatostatin receptor 5 2.6415
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.59215
MGMT O-6-methylguanine-DNA methyltransferase 2.5897
NKX2-8 NK2 homeobox 8 2.5575
PDCD1 programmed cell death 1 2.5361
CBARP CACN subunit beta associated regulatory protein 2.53575
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.50175
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.4846
NTN3 netrin 3 2.47285
TLE6 transducin-like enhancer of split 6 2.46545
IGHMBP2 immunoglobulin mu binding protein 2 2.45977
SCT secretin 2.4578
ZBTB7B zinc finger and BTB domain containing 7B 2.4562
NPAS1 neuronal PAS domain protein 1 2.4407
CORO1A coronin, actin binding protein, 1A 2.4303
KRT3 keratin 3, type II 2.40775
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.405
ATP5PB ATP synthase peripheral stalk-membrane subunit b 2.3841
PXDNL peroxidasin-like 2.3747
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 2.36985
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.36955
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 2.36088
WASF1 WAS protein family, member 1 2.35615
SPEF1 sperm flagellar 1 2.3487
CGRRF1 cell growth regulator with ring finger domain 1 2.34495
CHAF1B chromatin assembly factor 1, subunit B (p60) 2.3431
HOXD10 homeobox D10 2.33495
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.31925
THAP3 THAP domain containing, apoptosis associated protein 3 2.31235
TULP1 tubby like protein 1 2.29025
OXT oxytocin/neurophysin I prepropeptide 2.2863
CCDC70 coiled-coil domain containing 70 2.2697
MORN1 MORN repeat containing 1 2.2619
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 2.25705
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 2.25705
APOA4 apolipoprotein A-IV 2.24415
TJP3 tight junction protein 3 2.24318
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 2.23415
PSPN persephin 2.23375
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.23245
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.2302
SHH sonic hedgehog 2.22615
HCRT hypocretin (orexin) neuropeptide precursor 2.2237
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 2.22283
SORBS1 sorbin and SH3 domain containing 1 2.2204
MYH13 myosin, heavy chain 13, skeletal muscle 2.2164
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.21035
LCN1 lipocalin 1 2.2097
GRM2 glutamate receptor, metabotropic 2 2.2036
MLANA melan-A 2.18218
ABHD8 abhydrolase domain containing 8 2.1651
MAPK4 mitogen-activated protein kinase 4 2.16145
DUX4 double homeobox 4 2.14375
NEIL1 nei endonuclease VIII-like 1 (E. coli) 2.1406
TRIM11 tripartite motif containing 11 2.14055
STK11 serine/threonine kinase 11 2.13473
MTCH2 mitochondrial carrier 2 2.1346
AP4M1 adaptor-related protein complex 4, mu 1 subunit 2.1277
PIERCE1 piercer of microtubule wall 1 2.12313
PCDHA10 protocadherin alpha 10 2.1145
H1-1 H1.1 linker histone, cluster member 2.11155
GPR37L1 G protein-coupled receptor 37 like 1 2.1091
TPST1 tyrosylprotein sulfotransferase 1 2.10905
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.09805
TYR tyrosinase 2.09045
POMC proopiomelanocortin 2.08685
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 2.0798
CD79B CD79b molecule, immunoglobulin-associated beta 2.07265
CAPN3 calpain 3, (p94) 2.06418
ZBED1 zinc finger, BED-type containing 1 2.0534
RAMP1 receptor (G protein-coupled) activity modifying protein 1 2.04405
SIGLEC15 sialic acid binding Ig-like lectin 15 2.0299
PGLYRP1 peptidoglycan recognition protein 1 2.0291
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.026
NMUR1 neuromedin U receptor 1 2.02585
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 2.02425
GPR25 G protein-coupled receptor 25 2.02385
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 2.02338
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.01465
GJA3 gap junction protein, alpha 3, 46kDa 2.01425
RAB40C RAB40C, member RAS oncogene family 2.01195
PELI2 pellino E3 ubiquitin protein ligase family member 2 2.0112
LMO1 LIM domain only 1 (rhombotin 1) 2.009
CSNK1G1 casein kinase 1, gamma 1 2.00402
CATSPERH catsper channel auxiliary subunit eta 2.0019

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.53285
TUBB6 tubulin, beta 6 class V -5.2358
TMEM109 transmembrane protein 109 -5.1519
TM9SF3 transmembrane 9 superfamily member 3 -4.67195
GOLT1B golgi transport 1B -4.2916
ANXA2 annexin A2 -3.65837
RECQL RecQ helicase-like -3.51466
BASP1 brain abundant, membrane attached signal protein 1 -3.4617
KRT14 keratin 14, type I -3.0723
TMED9 transmembrane emp24 protein transport domain containing 9 -2.51178
STAT1 signal transducer and activator of transcription 1, 91kDa -2.48563
M6PR mannose-6-phosphate receptor (cation dependent) -2.45967
METTL1 methyltransferase like 1 -2.4044
CREB3L2 cAMP responsive element binding protein 3-like 2 -2.38445
NEMP1 nuclear envelope integral membrane protein 1 -2.36385
NGRN neugrin, neurite outgrowth associated -2.3402
NT5DC2 5'-nucleotidase domain containing 2 -2.31955
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) -2.301
RPA3 replication protein A3, 14kDa -2.24565
EEF1AKMT3 EEF1A lysine methyltransferase 3 -2.20235
LGALS1 lectin, galactoside-binding, soluble, 1 -2.1366
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.13173
THADA thyroid adenoma associated -2.13142
TIMP1 TIMP metallopeptidase inhibitor 1 -2.1057
GATAD1 GATA zinc finger domain containing 1 -2.06507
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.0435
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) -2.0248