CRCGN015_MCF10A.TP53.M_24H:C15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxyquinoline 11.27 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:C15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 5.0
KLHL9 kelch-like family member 9 4.07478
TSEN2 TSEN2 tRNA splicing endonuclease subunit 4.0624
ACAA1 acetyl-CoA acyltransferase 1 3.33192
HLA-DRA major histocompatibility complex, class II, DR alpha 3.22165
BAMBI BMP and activin membrane-bound inhibitor 2.89995
CNRIP1 cannabinoid receptor interacting protein 1 2.77115
TLCD3A TLC domain containing 3A 2.63385
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.6261
PEX11B peroxisomal biogenesis factor 11 beta 2.51515
GSTZ1 glutathione S-transferase zeta 1 2.47595
EVL Enah/Vasp-like 2.4091
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.3205
METTL18 methyltransferase like 18 2.2417
CETN3 centrin, EF-hand protein, 3 2.1786
TEFM transcription elongation factor, mitochondrial 2.1711
OLFML2B olfactomedin-like 2B 2.05065
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 2.0375

decreased expression

Symbol Name Standardized Value
YME1L1 YME1-like 1 ATPase -5.1436
TCTA T-cell leukemia translocation altered -5.0376
PGAM4 phosphoglycerate mutase family member 4 -4.88405
HMG20B high mobility group 20B -4.69158
VDAC1 voltage-dependent anion channel 1 -4.0414
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 -2.78085
GRWD1 glutamate-rich WD repeat containing 1 -2.60225
POU2F1 POU class 2 homeobox 1 -2.5023
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.38168
AMOTL2 angiomotin like 2 -2.3679
FHL5 four and a half LIM domains 5 -2.32065
ATP11B ATPase, class VI, type 11B -2.21215
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 -2.07
PIH1D1 PIH1 domain containing 1 -2.03875
GSTT1 glutathione S-transferase theta 1 -2.01755