CRCGN015_MCF10A.TP53.M_24H:C17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-nitronaphthalene 33.66 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

97 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:C17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LGMN legumain 7.01815
CCP110 centriolar coiled coil protein 110kDa 5.5214
WFS1 Wolfram syndrome 1 (wolframin) 4.93215
TIMP2 TIMP metallopeptidase inhibitor 2 4.6631
C2CD2 C2 calcium-dependent domain containing 2 4.01615
FKBP14 FK506 binding protein 14, 22 kDa 3.93105
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.56365
APOE apolipoprotein E 3.3082
TEX10 testis expressed 10 2.98205
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.96685
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.87295
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 2.71107
TFF3 trefoil factor 3 (intestinal) 2.69375
LYN LYN proto-oncogene, Src family tyrosine kinase 2.60405
STMN4 stathmin-like 4 2.5382
BMP6 bone morphogenetic protein 6 2.4724
ITFG1 integrin alpha FG-GAP repeat containing 1 2.45865
TH tyrosine hydroxylase 2.43015
MFSD1 major facilitator superfamily domain containing 1 2.42715
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 2.4004
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.34315
GLB1L2 galactosidase, beta 1-like 2 2.3374
CTSZ cathepsin Z 2.3186
SPA17 sperm autoantigenic protein 17 2.309
IL33 interleukin 33 2.3071
BLMH bleomycin hydrolase 2.26475
ISL1 ISL LIM homeobox 1 2.2635
CCNA1 cyclin A1 2.26065
BCR breakpoint cluster region 2.2481
FSD1 fibronectin type III and SPRY domain containing 1 2.24425
RPIA ribose 5-phosphate isomerase A 2.2318
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 2.2274
TSNAXIP1 translin-associated factor X interacting protein 1 2.19025
METTL4 methyltransferase like 4 2.17075
CCDC81 coiled-coil domain containing 81 2.1556
FRS2 fibroblast growth factor receptor substrate 2 2.1493
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.1321
TULP4 tubby like protein 4 2.12535
CEP170 centrosomal protein 170kDa 2.1103
IL20RA interleukin 20 receptor, alpha 2.10615
GCC1 GRIP and coiled-coil domain containing 1 2.06875
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.0655
SETD6 SET domain containing 6 2.05835
SSBP1 single-stranded DNA binding protein 1, mitochondrial 2.0572
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 2.05205
LY86 lymphocyte antigen 86 2.03235
CALML4 calmodulin-like 4 2.02945
ARC activity-regulated cytoskeleton-associated protein 2.02485
TERT telomerase reverse transcriptase 2.0244
EGLN1 egl-9 family hypoxia-inducible factor 1 2.02275
SYK spleen tyrosine kinase 2.02185
HMMR hyaluronan-mediated motility receptor (RHAMM) 2.0199
TMEM260 transmembrane protein 260 2.014
DBN1 drebrin 1 2.01298
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 2.0109

decreased expression

Symbol Name Standardized Value
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.77115
RNF167 ring finger protein 167 -4.58555
HAT1 histone acetyltransferase 1 -4.57785
NUP85 nucleoporin 85kDa -4.47365
LLGL2 lethal giant larvae homolog 2 (Drosophila) -3.7048
AMDHD2 amidohydrolase domain containing 2 -3.3833
MRPL58 mitochondrial ribosomal protein L58 -3.2629
KRT14 keratin 14, type I -3.09725
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.86715
TIMP1 TIMP metallopeptidase inhibitor 1 -2.8361
TUBA4A tubulin, alpha 4a -2.7264
MRPS7 mitochondrial ribosomal protein S7 -2.6662
KCTD2 potassium channel tetramerization domain containing 2 -2.65733
NT5C 5', 3'-nucleotidase, cytosolic -2.5879
CREB1 cAMP responsive element binding protein 1 -2.47356
TMEM94 transmembrane protein 94 -2.412
CASKIN2 CASK interacting protein 2 -2.40427
CCL17 chemokine (C-C motif) ligand 17 -2.3803
ETV7 ets variant 7 -2.37585
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 -2.36648
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.35375
PRCP prolylcarboxypeptidase (angiotensinase C) -2.34085
ACTN4 actinin, alpha 4 -2.3403
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 -2.3093
ZBED5 zinc finger, BED-type containing 5 -2.28185
CLUH clustered mitochondria (cluA/CLU1) homolog -2.2598
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) -2.2254
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -2.2184
AARS1 alanyl-tRNA synthetase 1 -2.1986
VMP1 vacuole membrane protein 1 -2.19795
PIEZO1 piezo-type mechanosensitive ion channel component 1 -2.15585
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -2.1492
TAC4 tachykinin 4 (hemokinin) -2.1049
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 -2.1015
CCNL2 cyclin L2 -2.06715
PRPF3 pre-mRNA processing factor 3 -2.06605
ZBTB32 zinc finger and BTB domain containing 32 -2.0621
CDR2L cerebellar degeneration-related protein 2-like -2.05605
SAP30BP SAP30 binding protein -2.05525
SUMO4 small ubiquitin-like modifier 4 -2.0227
EMD emerin -2.01465
PRX periaxin -2.01435