CRCGN015_MCF10A.TP53.M_24H:D01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description serotonin 100.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:D01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TBX2 T-box 2 6.27661
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.28603
GATA2 GATA binding protein 2 3.7276
HBB hemoglobin, beta 3.18765
RNF167 ring finger protein 167 2.79928
CYB5R1 cytochrome b5 reductase 1 2.79819
HBA1 hemoglobin, alpha 1 2.73987
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.71011
AGR2 anterior gradient 2 2.57205
NVL nuclear VCP-like 2.56351
ATAD3A ATPase family, AAA domain containing 3A 2.4314
DNM2 dynamin 2 2.3235
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.28506
F13A1 coagulation factor XIII, A1 polypeptide 2.27251
C1R complement component 1, r subcomponent 2.21672
TM7SF3 transmembrane 7 superfamily member 3 2.07473
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 2.0659
LAD1 ladinin 1 2.06168
EYA1 EYA transcriptional coactivator and phosphatase 1 2.00292
COQ8A coenzyme Q8A 2.00206

decreased expression

Symbol Name Standardized Value
PLK1 polo-like kinase 1 -5.24204
HMG20B high mobility group 20B -5.1764
PMM2 phosphomannomutase 2 -4.84343
NUP85 nucleoporin 85kDa -4.8077
RAI14 retinoic acid induced 14 -4.47027
SGK1 serum/glucocorticoid regulated kinase 1 -4.02224
CD44 CD44 molecule (Indian blood group) -3.88416
HEATR1 HEAT repeat containing 1 -3.6249
TOR1A torsin family 1, member A (torsin A) -3.52386
MRPL58 mitochondrial ribosomal protein L58 -3.01616
PALB2 partner and localizer of BRCA2 -2.78599
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.57984
NPTX1 neuronal pentraxin I -2.50373
ROPN1B rhophilin associated tail protein 1B -2.33333
ACTG2 actin, gamma 2, smooth muscle, enteric -2.29005
TSPAN3 tetraspanin 3 -2.17784
CALB2 calbindin 2 -2.11251
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.08244
ZC4H2 zinc finger, C4H2 domain containing -2.04293
S100A1 S100 calcium binding protein A1 -2.02694
PARN poly(A)-specific ribonuclease -2.01034