CRCGN015_MCF10A.TP53.M_24H:D03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description serotonin 11.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

287 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:D03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 7.82657
CASP2 caspase 2, apoptosis-related cysteine peptidase 6.91471
AGR2 anterior gradient 2 5.00396
MTA2 metastasis associated 1 family, member 2 4.60074
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 4.38173
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.36987
CXCR4 chemokine (C-X-C motif) receptor 4 4.24956
MDM4 MDM4, p53 regulator 4.11378
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 3.85851
NUTF2 nuclear transport factor 2 3.68156
MAST2 microtubule associated serine/threonine kinase 2 3.67528
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 3.58186
MAMLD1 mastermind-like domain containing 1 3.507
ANO10 anoctamin 10 3.48705
STX4 syntaxin 4 3.42455
RBBP5 retinoblastoma binding protein 5 3.42276
SPATA6 spermatogenesis associated 6 3.36635
RNF139 ring finger protein 139 3.30163
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 3.27857
COMP cartilage oligomeric matrix protein 3.22362
ACTR8 ARP8 actin-related protein 8 homolog (yeast) 3.18625
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 3.10814
CAPN5 calpain 5 3.08323
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 3.06419
PCCA propionyl CoA carboxylase, alpha polypeptide 3.04177
OPCML opioid binding protein/cell adhesion molecule-like 3.03651
OSTF1 osteoclast stimulating factor 1 2.98659
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 2.96749
FKBP14 FK506 binding protein 14, 22 kDa 2.94453
LYN LYN proto-oncogene, Src family tyrosine kinase 2.94054
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 2.93268
NKAPD1 NKAP domain containing 1 2.93048
ZNF365 zinc finger protein 365 2.9091
PTPRS protein tyrosine phosphatase, receptor type, S 2.89371
PRR5L proline rich 5 like 2.87076
STK17B serine/threonine kinase 17b 2.85335
KLRC1 killer cell lectin-like receptor subfamily C, member 1 2.85291
PDZD8 PDZ domain containing 8 2.84049
RAMP1 receptor (G protein-coupled) activity modifying protein 1 2.83563
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.81488
BBS10 Bardet-Biedl syndrome 10 2.80996
CEPT1 choline/ethanolamine phosphotransferase 1 2.80316
THRAP3 thyroid hormone receptor associated protein 3 2.75049
ADAM17 ADAM metallopeptidase domain 17 2.74754
KLRC3 killer cell lectin-like receptor subfamily C, member 3 2.74201
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.72862
NDP Norrie disease (pseudoglioma) 2.71099
CCL2 chemokine (C-C motif) ligand 2 2.68462
RIT2 Ras-like without CAAX 2 2.68341
STRN3 striatin, calmodulin binding protein 3 2.678
CILK1 ciliogenesis associated kinase 1 2.64933
SPATA20 spermatogenesis associated 20 2.63301
CHODL chondrolectin 2.62726
ZNF652 zinc finger protein 652 2.61648
BATF3 basic leucine zipper transcription factor, ATF-like 3 2.60795
TTC12 tetratricopeptide repeat domain 12 2.59261
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.58956
LSAMP limbic system-associated membrane protein 2.57897
GPR17 G protein-coupled receptor 17 2.56958
PTPRE protein tyrosine phosphatase, receptor type, E 2.54927
KRT19 keratin 19, type I 2.53056
ZNF529 zinc finger protein 529 2.51995
KRT36 keratin 36, type I 2.51561
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.50834
FAM131B family with sequence similarity 131, member B 2.5018
MOCS3 molybdenum cofactor synthesis 3 2.49899
PEDS1 plasmanylethanolamine desaturase 1 2.49495
TP53 tumor protein p53 2.48824
PID1 phosphotyrosine interaction domain containing 1 2.48115
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.45557
VIL1 villin 1 2.43923
STK10 serine/threonine kinase 10 2.43074
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 2.42858
NRBF2 nuclear receptor binding factor 2 2.42136
ZNF329 zinc finger protein 329 2.42112
MEGF8 multiple EGF-like-domains 8 2.42063
AOC1 amine oxidase, copper containing 1 2.40963
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.40416
PRR3 proline rich 3 2.39453
STAT2 signal transducer and activator of transcription 2, 113kDa 2.39262
CCL24 chemokine (C-C motif) ligand 24 2.38585
IL19 interleukin 19 2.37599
LGMN legumain 2.37575
HRC histidine rich calcium binding protein 2.36804
TWSG1 twisted gastrulation BMP signaling modulator 1 2.36533
SPDEF SAM pointed domain containing ETS transcription factor 2.36346
ZNF286A zinc finger protein 286A 2.35305
CA10 carbonic anhydrase X 2.35036
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 2.34987
FAM168A family with sequence similarity 168, member A 2.33036
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.33007
HBA1 hemoglobin, alpha 1 2.32862
RRAGB Ras-related GTP binding B 2.31945
LEMD3 LEM domain containing 3 2.31609
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.30989
ASB1 ankyrin repeat and SOCS box containing 1 2.30778
NUP155 nucleoporin 155kDa 2.30419
GLIPR1 GLI pathogenesis-related 1 2.29796
IL9 interleukin 9 2.2974
ATRNL1 attractin-like 1 2.29686
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.29177
REG1B regenerating islet-derived 1 beta 2.2852
LRP3 low density lipoprotein receptor-related protein 3 2.28122
ASTN1 astrotactin 1 2.28027
KLRC4 killer cell lectin-like receptor subfamily C, member 4 2.27742
MED18 mediator complex subunit 18 2.2703
MTM1 myotubularin 1 2.25365
JOSD1 Josephin domain containing 1 2.24865
IMPACT impact RWD domain protein 2.24509
IL26 interleukin 26 2.24384
TMLHE trimethyllysine hydroxylase, epsilon 2.23734
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.23681
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 2.23665
DPY19L1 dpy-19-like 1 (C. elegans) 2.23245
DEFA5 defensin, alpha 5, Paneth cell-specific 2.2316
SNTG1 syntrophin, gamma 1 2.22472
GSR glutathione reductase 2.22307
CASP6 caspase 6, apoptosis-related cysteine peptidase 2.22262
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.22124
LSM12 LSM12 homolog (S. cerevisiae) 2.2167
FLOT2 flotillin 2 2.21182
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.21108
DBF4B DBF4 zinc finger B 2.20981
AKAP3 A kinase (PRKA) anchor protein 3 2.20971
PIAS3 protein inhibitor of activated STAT, 3 2.19539
CNIH3 cornichon family AMPA receptor auxiliary protein 3 2.18864
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.18746
RNF170 ring finger protein 170 2.18653
CASP8 caspase 8, apoptosis-related cysteine peptidase 2.18591
REL v-rel avian reticuloendotheliosis viral oncogene homolog 2.18035
DENND5B DENN/MADD domain containing 5B 2.17999
ACSL5 acyl-CoA synthetase long-chain family member 5 2.17975
DCAKD dephospho-CoA kinase domain containing 2.1783
MAP2K6 mitogen-activated protein kinase kinase 6 2.17818
SMPX small muscle protein, X-linked 2.17032
DEFA6 defensin, alpha 6, Paneth cell-specific 2.16075
INSL6 insulin-like 6 2.16051
JMJD1C jumonji domain containing 1C 2.15603
CD160 CD160 molecule 2.15556
AGK acylglycerol kinase 2.14656
ZNF415 zinc finger protein 415 2.14609
TERF2 telomeric repeat binding factor 2 2.14537
GARRE1 granule associated Rac and RHOG effector 1 2.14278
PRR16 proline rich 16 2.13841
ANKRD44 ankyrin repeat domain 44 2.13166
COPG1 coatomer protein complex, subunit gamma 1 2.12738
KCNIP1 Kv channel interacting protein 1 2.12223
KLRD1 killer cell lectin-like receptor subfamily D, member 1 2.12097
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.11666
APLP2 amyloid beta (A4) precursor-like protein 2 2.11427
SOCS5 suppressor of cytokine signaling 5 2.11397
ZFP91 ZFP91 zinc finger protein 2.11237
SSPN sarcospan 2.10345
HOXC5 homeobox C5 2.10222
DACT1 dishevelled-binding antagonist of beta-catenin 1 2.10101
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.10043
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.09954
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.09619
PKN1 protein kinase N1 2.09609
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 2.09334
TYROBP TYRO protein tyrosine kinase binding protein 2.09241
SLC16A4 solute carrier family 16, member 4 2.0915
ZFC3H1 zinc finger, C3H1-type containing 2.09086
NLGN1 neuroligin 1 2.08668
GPX5 glutathione peroxidase 5 2.08136
RNF32 ring finger protein 32 2.08068
SIRT3 sirtuin 3 2.08019
MMP26 matrix metallopeptidase 26 2.07394
RSF1 remodeling and spacing factor 1 2.07284
ZNF667 zinc finger protein 667 2.07247
ZCCHC10 zinc finger, CCHC domain containing 10 2.07213
NRXN2 neurexin 2 2.07188
PRPF39 pre-mRNA processing factor 39 2.07172
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.07114
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.06399
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.06389
GOLGA8A golgin A8 family, member A 2.05587
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 2.053
FGF20 fibroblast growth factor 20 2.0474
NR2F1 nuclear receptor subfamily 2, group F, member 1 2.04608
TRIM68 tripartite motif containing 68 2.04084
TMBIM4 transmembrane BAX inhibitor motif containing 4 2.04033
PDE12 phosphodiesterase 12 2.03906
NME5 NME/NM23 family member 5 2.03855
TBL1Y transducin (beta)-like 1, Y-linked 2.03836
TRIL TLR4 interactor with leucine-rich repeats 2.033
LCT lactase 2.03281
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 2.02954
HBB hemoglobin, beta 2.02881
SENP7 SUMO1/sentrin specific peptidase 7 2.02594
FGF14 fibroblast growth factor 14 2.02482
KLHL35 kelch-like family member 35 2.02331
ZNF813 zinc finger protein 813 2.02088
ANKRD36C ankyrin repeat domain 36C 2.01899
TBC1D31 TBC1 domain family, member 31 2.01511
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like 2.01438
FGD2 FYVE, RhoGEF and PH domain containing 2 2.0121
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 2.01138
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 2.0081
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 2.00619
MYH7 myosin, heavy chain 7, cardiac muscle, beta 2.00565
TULP2 tubby like protein 2 2.00535
SPATA31C1 SPATA31 subfamily C, member 1 2.00509
TRIM24 tripartite motif containing 24 2.00475
SPACA9 sperm acrosome associated 9 2.00314
FHL5 four and a half LIM domains 5 2.00156
INCENP inner centromere protein antigens 135/155kDa 2.00117

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -5.70102
PCNA proliferating cell nuclear antigen -4.72394
PMM2 phosphomannomutase 2 -4.58873
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.57451
LAP3 leucine aminopeptidase 3 -4.48335
HMG20B high mobility group 20B -4.39696
TRAPPC3 trafficking protein particle complex 3 -3.58853
SNX5 sorting nexin 5 -3.45351
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -3.27856
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -3.23692
RPS5 ribosomal protein S5 -3.18063
ZNF133 zinc finger protein 133 -3.06906
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.04261
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.9493
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.80172
SECISBP2 SECIS binding protein 2 -2.78828
HAT1 histone acetyltransferase 1 -2.78704
NOP10 NOP10 ribonucleoprotein -2.76735
CD34 CD34 molecule -2.68776
HMOX2 heme oxygenase 2 -2.6836
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.67308
VAT1 vesicle amine transport 1 -2.6613
TLK2 tousled-like kinase 2 -2.66126
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.60895
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -2.60073
RBM47 RNA binding motif protein 47 -2.59906
ACAA1 acetyl-CoA acyltransferase 1 -2.58541
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.58526
SNRPN small nuclear ribonucleoprotein polypeptide N -2.57073
TMEM230 transmembrane protein 230 -2.55886
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.52849
AVPI1 arginine vasopressin-induced 1 -2.5189
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -2.51605
SEC23B Sec23 homolog B (S. cerevisiae) -2.51396
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -2.49687
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -2.47751
CASP8AP2 caspase 8 associated protein 2 -2.4282
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.4279
TMEM208 transmembrane protein 208 -2.36288
HSPA4L heat shock 70kDa protein 4-like -2.35529
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -2.35438
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.35163
SCYL3 SCY1-like 3 (S. cerevisiae) -2.34193
CA2 carbonic anhydrase II -2.33845
COTL1 coactosin-like F-actin binding protein 1 -2.32115
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.31476
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.31385
PYGB phosphorylase, glycogen; brain -2.3109
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.29366
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.27904
ZNF219 zinc finger protein 219 -2.26912
CLTB clathrin, light chain B -2.25901
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -2.24595
PARN poly(A)-specific ribonuclease -2.22741
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.21623
CRLF1 cytokine receptor-like factor 1 -2.21623
CXCL9 chemokine (C-X-C motif) ligand 9 -2.21126
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.2062
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -2.17774
CALML5 calmodulin-like 5 -2.17116
PANK2 pantothenate kinase 2 -2.15969
ZC3H7A zinc finger CCCH-type containing 7A -2.14826
DDRGK1 DDRGK domain containing 1 -2.12864
RHOB ras homolog family member B -2.11295
ACBD4 acyl-CoA binding domain containing 4 -2.11045
DUSP6 dual specificity phosphatase 6 -2.10182
SH3GL1 SH3-domain GRB2-like 1 -2.10123
ATOX1 antioxidant 1 copper chaperone -2.09863
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.09378
STXBP2 syntaxin binding protein 2 -2.09134
GSTO1 glutathione S-transferase omega 1 -2.08967
METTL22 methyltransferase like 22 -2.08261
OGDHL oxoglutarate dehydrogenase-like -2.07846
DND1 DND microRNA-mediated repression inhibitor 1 -2.0761
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.05644
MRPL34 mitochondrial ribosomal protein L34 -2.04052
ECSIT ECSIT signalling integrator -2.03953
UBE3C ubiquitin protein ligase E3C -2.03411
PAQR4 progestin and adipoQ receptor family member IV -2.02689
SEC61B Sec61 beta subunit -2.0113