CRCGN015_MCF10A.TP53.M_24H:D05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fm550 perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:D05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIAM1 T-cell lymphoma invasion and metastasis 1 4.00542
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.76454
AGR2 anterior gradient 2 3.72449
E2F2 E2F transcription factor 2 3.72128
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.59248
CNRIP1 cannabinoid receptor interacting protein 1 3.23792
PRKCH protein kinase C, eta 2.94799
LGMN legumain 2.5187
PYCR1 pyrroline-5-carboxylate reductase 1 2.45558
TSKU tsukushi, small leucine rich proteoglycan 2.41661
SYNE2 spectrin repeat containing, nuclear envelope 2 2.39407
AP5M1 adaptor-related protein complex 5, mu 1 subunit 2.37159
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.33279
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.27182
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.21608
LAGE3 L antigen family, member 3 2.21346
MTA2 metastasis associated 1 family, member 2 2.13128
DPH2 DPH2 homolog (S. cerevisiae) 2.11013
HOXA5 homeobox A5 2.06581
ECH1 enoyl CoA hydratase 1, peroxisomal 2.03015
MDM4 MDM4, p53 regulator 2.01181

decreased expression

Symbol Name Standardized Value
HAT1 histone acetyltransferase 1 -6.22452
TNIP1 TNFAIP3 interacting protein 1 -4.63352
BASP1 brain abundant, membrane attached signal protein 1 -4.07575
COTL1 coactosin-like F-actin binding protein 1 -4.02456
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.92732
DSG2 desmoglein 2 -3.59036
MTERF3 mitochondrial transcription termination factor 3 -3.25209
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.19833
NRIP1 nuclear receptor interacting protein 1 -2.80662
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.74323
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.45575
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.32016
FBN1 fibrillin 1 -2.20444
RAD51C RAD51 paralog C -2.17168
PSIP1 PC4 and SFRS1 interacting protein 1 -2.15983
RPA3 replication protein A3, 14kDa -2.13041
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -2.09159
RHOG ras homolog family member G -2.0124