CRCGN015_MCF10A.TP53.M_24H:D06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fm550 perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

72 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:D06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INTS3 integrator complex subunit 3 4.84611
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.36219
WFS1 Wolfram syndrome 1 (wolframin) 4.14345
PPARG peroxisome proliferator-activated receptor gamma 4.14096
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.61421
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.60625
MYO5C myosin VC 2.5894
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.54852
TLCD3A TLC domain containing 3A 2.53041
DPY19L4 dpy-19-like 4 (C. elegans) 2.35601
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2.32088
SNX17 sorting nexin 17 2.19931
SCML2 sex comb on midleg-like 2 (Drosophila) 2.19904
NBEAL2 neurobeachin-like 2 2.19774
SCAND1 SCAN domain containing 1 2.19768
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.18836
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 2.10519
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.09511
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.0932
LAMA2 laminin, alpha 2 2.09264
S100A4 S100 calcium binding protein A4 2.09013
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 2.06309
HSPA4L heat shock 70kDa protein 4-like 2.01465
ZNF106 zinc finger protein 106 2.00601

decreased expression

Symbol Name Standardized Value
MRPS2 mitochondrial ribosomal protein S2 -5.20161
FPGS folylpolyglutamate synthase -4.63485
CHMP4B charged multivesicular body protein 4B -4.62325
TNIP1 TNFAIP3 interacting protein 1 -4.59668
TES testin LIM domain protein -4.2081
PCNA proliferating cell nuclear antigen -4.18603
TXNDC9 thioredoxin domain containing 9 -3.945
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.8039
CD320 CD320 molecule -3.60263
PFN1 profilin 1 -3.23577
RBM34 RNA binding motif protein 34 -3.01895
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.9299
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.90886
TENT4A terminal nucleotidyltransferase 4A -2.8173
PAEP progestagen-associated endometrial protein -2.68127
TIMP1 TIMP metallopeptidase inhibitor 1 -2.68086
RAI14 retinoic acid induced 14 -2.60195
KCNK12 potassium channel, two pore domain subfamily K, member 12 -2.5555
MFGE8 milk fat globule-EGF factor 8 protein -2.5501
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.54754
TXNRD1 thioredoxin reductase 1 -2.5426
PANK2 pantothenate kinase 2 -2.54201
DCK deoxycytidine kinase -2.45501
TRIB3 tribbles pseudokinase 3 -2.4088
MSN moesin -2.37607
ENTR1 endosome associated trafficking regulator 1 -2.25232
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.21117
CSNK1G3 casein kinase 1, gamma 3 -2.20502
ZMAT3 zinc finger, matrin-type 3 -2.18875
BFAR bifunctional apoptosis regulator -2.15357
TMEM127 transmembrane protein 127 -2.14376
SEC16A SEC16 homolog A (S. cerevisiae) -2.14148
SOWAHC sosondowah ankyrin repeat domain family member C -2.13878
ZNF667 zinc finger protein 667 -2.1024
PARP6 poly (ADP-ribose) polymerase family, member 6 -2.10162
ORM1 orosomucoid 1 -2.09852
TBCC tubulin folding cofactor C -2.08263
OSTM1 osteopetrosis associated transmembrane protein 1 -2.07931
KRTAP1-1 keratin associated protein 1-1 -2.05406
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 -2.04835
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -2.02996
CEND1 cell cycle exit and neuronal differentiation 1 -2.02627
ZNF79 zinc finger protein 79 -2.02498
EXTL1 exostosin-like glycosyltransferase 1 -2.02297
TRAPPC10 trafficking protein particle complex 10 -2.01993
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.01913
ZFPM1 zinc finger protein, FOG family member 1 -2.01788
KCNK3 potassium channel, two pore domain subfamily K, member 3 -2.00856