CRCGN015_MCF10A.TP53.M_24H:D10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description metronidazole 103.49 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

87 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:D10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 4.4233
CNRIP1 cannabinoid receptor interacting protein 1 4.34945
COMP cartilage oligomeric matrix protein 3.84865
MAST2 microtubule associated serine/threonine kinase 2 3.47878
WIF1 WNT inhibitory factor 1 3.01865
DENND2D DENN/MADD domain containing 2D 2.67265
PDLIM1 PDZ and LIM domain 1 2.61975
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 2.58555
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 2.57835
GSTZ1 glutathione S-transferase zeta 1 2.4732
SP3 Sp3 transcription factor 2.4607
TBPL1 TBP-like 1 2.42935
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 2.392
TRAPPC2L trafficking protein particle complex 2-like 2.3724
TLCD3A TLC domain containing 3A 2.28705
NUCB2 nucleobindin 2 2.23525
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 2.23405
YAF2 YY1 associated factor 2 2.15755
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 2.1568
GPX7 glutathione peroxidase 7 2.1424
PIAS3 protein inhibitor of activated STAT, 3 2.12795
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.09955
NAXD NAD(P)HX dehydratase 2.09915
FAF1 Fas (TNFRSF6) associated factor 1 2.08305
UTP11 UTP11 small subunit processome component 2.081
NIT2 nitrilase family, member 2 2.0467
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 2.0184
BAG2 BCL2-associated athanogene 2 2.01745
MRPL58 mitochondrial ribosomal protein L58 2.00285
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) 2.00035

decreased expression

Symbol Name Standardized Value
RNF167 ring finger protein 167 -10.0
TCTA T-cell leukemia translocation altered -5.33575
PCNA proliferating cell nuclear antigen -5.33015
BASP1 brain abundant, membrane attached signal protein 1 -5.08225
CHIC2 cysteine-rich hydrophobic domain 2 -4.7627
CCNB1 cyclin B1 -4.7371
HMG20B high mobility group 20B -4.52688
SGK1 serum/glucocorticoid regulated kinase 1 -4.5032
KIF20A kinesin family member 20A -4.4438
PFN1 profilin 1 -4.37525
CCNB2 cyclin B2 -4.2003
CANT1 calcium activated nucleotidase 1 -3.97648
FKBP1C FK506 binding protein 1C -3.22547
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 -2.81165
DDRGK1 DDRGK domain containing 1 -2.76115
MPDU1 mannose-P-dolichol utilization defect 1 -2.6118
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.5769
C1QBP complement component 1, q subcomponent binding protein -2.52945
COTL1 coactosin-like F-actin binding protein 1 -2.5127
PM20D1 peptidase M20 domain containing 1 -2.47248
CNPY4 canopy FGF signaling regulator 4 -2.38215
FKBP1A FK506 binding protein 1A, 12kDa -2.37133
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.35745
TMEM230 transmembrane protein 230 -2.354
CELF3 CUGBP, Elav-like family member 3 -2.31037
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -2.2704
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 -2.27005
ZBTB22 zinc finger and BTB domain containing 22 -2.26025
PCCB propionyl CoA carboxylase, beta polypeptide -2.25655
MMP8 matrix metallopeptidase 8 -2.24945
HTRA1 HtrA serine peptidase 1 -2.21695
SDC2 syndecan 2 -2.20733
PDCD6 programmed cell death 6 -2.1989
CREB5 cAMP responsive element binding protein 5 -2.19515
TRPV6 transient receptor potential cation channel, subfamily V, member 6 -2.193
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -2.1848
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 -2.181
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.16985
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon -2.15905
ZNF133 zinc finger protein 133 -2.15868
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -2.1537
FPR3 formyl peptide receptor 3 -2.14465
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.14125
DERL2 derlin 2 -2.138
TMEM254 transmembrane protein 254 -2.1309
PANK2 pantothenate kinase 2 -2.12925
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.09188
CALCOCO1 calcium binding and coiled-coil domain 1 -2.086
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.08057
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.07455
ANKH ANKH inorganic pyrophosphate transport regulator -2.05675
GJB1 gap junction protein, beta 1, 32kDa -2.05445
SCARA3 scavenger receptor class A, member 3 -2.038
LITAF lipopolysaccharide-induced TNF factor -2.02143
CTSD cathepsin D -2.0128
DDA1 DET1 and DDB1 associated 1 -2.00905
HLA-DMB major histocompatibility complex, class II, DM beta -2.00395