CRCGN015_MCF10A.TP53.M_24H:D13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1,1-trichloroethane, technical grade 98.44 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

151 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:D13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 5.63365
ZNF134 zinc finger protein 134 5.52
CASP2 caspase 2, apoptosis-related cysteine peptidase 5.06389
MAMLD1 mastermind-like domain containing 1 5.0
ZNF587B zinc finger protein 587B 4.9608
ZNF551 zinc finger protein 551 4.7221
SSBP2 single-stranded DNA binding protein 2 4.55813
AXIN1 axin 1 4.45865
HBA1 hemoglobin, alpha 1 4.28291
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.0188
FOS FBJ murine osteosarcoma viral oncogene homolog 3.9056
MTA2 metastasis associated 1 family, member 2 3.896
ZIM3 zinc finger, imprinted 3 3.83425
HLA-DRA major histocompatibility complex, class II, DR alpha 3.68932
IGHMBP2 immunoglobulin mu binding protein 2 3.61155
ZNF419 zinc finger protein 419 3.6097
ZNF587 zinc finger protein 587 3.55355
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 3.5274
TRAPPC2 trafficking protein particle complex 2 3.30883
ZNF671 zinc finger protein 671 3.2164
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 3.1271
ZNF665 zinc finger protein 665 3.0995
ZNF329 zinc finger protein 329 3.04065
ALS2CL ALS2 C-terminal like 3.017
ZNF304 zinc finger protein 304 2.98805
PRKCH protein kinase C, eta 2.92953
ZNF211 zinc finger protein 211 2.91185
MDM4 MDM4, p53 regulator 2.8786
ZNF544 zinc finger protein 544 2.86685
THRAP3 thyroid hormone receptor associated protein 3 2.7956
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) 2.7658
ZNF282 zinc finger protein 282 2.6591
ZNF253 zinc finger protein 253 2.6371
CNRIP1 cannabinoid receptor interacting protein 1 2.6204
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.59925
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.59365
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.58298
RTL10 retrotransposon Gag like 10 2.58075
LETM1 leucine zipper-EF-hand containing transmembrane protein 1 2.56168
ZNF652 zinc finger protein 652 2.5409
WDR33 WD repeat domain 33 2.52365
ERN2 endoplasmic reticulum to nucleus signaling 2 2.5223
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) 2.51765
RBBP5 retinoblastoma binding protein 5 2.5096
CHL1 cell adhesion molecule L1-like 2.44745
ZNF761 zinc finger protein 761 2.4456
GAST gastrin 2.43435
DENND2D DENN/MADD domain containing 2D 2.41625
ZNF8 zinc finger protein 8 2.41565
CELA3B chymotrypsin-like elastase family, member 3B 2.4099
ZNF93 zinc finger protein 93 2.40733
NOP14 NOP14 nucleolar protein 2.40675
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.39345
PRSS58 protease, serine, 58 2.3633
ZNF548 zinc finger protein 548 2.3554
NBPF19 neuroblastoma breakpoint family, member 19 2.32775
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa 2.2779
CPA2 carboxypeptidase A2 (pancreatic) 2.26275
KAT7 K(lysine) acetyltransferase 7 2.2512
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A 2.2489
RNF2 ring finger protein 2 2.2422
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.23983
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 2.2263
LOC122539214 Zinc finger protein LOC122539214 2.2215
CTRB2 chymotrypsinogen B2 2.21115
IL16 interleukin 16 2.20598
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 2.1967
HOXC8 homeobox C8 2.1765
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.17135
NFRKB nuclear factor related to kappaB binding protein 2.166
ZNF215 zinc finger protein 215 2.1646
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.1583
HIP1 huntingtin interacting protein 1 2.14132
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 2.1315
ASB7 ankyrin repeat and SOCS box containing 7 2.13055
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.11947
ZDHHC14 zinc finger, DHHC-type containing 14 2.11775
ZNF212 zinc finger protein 212 2.1071
AURKC aurora kinase C 2.09985
ZNF85 zinc finger protein 85 2.0952
COPG1 coatomer protein complex, subunit gamma 1 2.0937
TXNIP thioredoxin interacting protein 2.09285
ZNF273 zinc finger protein 273 2.08945
PEAK1 pseudopodium-enriched atypical kinase 1 2.0827
SH3BP1 SH3-domain binding protein 1 2.07655
RBM4 RNA binding motif protein 4 2.06375
WDR82 WD repeat domain 82 2.06135
BPIFA1 BPI fold containing family A, member 1 2.05225
REPIN1 replication initiator 1 2.0514
ZNF43 zinc finger protein 43 2.04575
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 2.044
LTK leukocyte receptor tyrosine kinase 2.04205
MMP1 matrix metallopeptidase 1 2.03395
USP19 ubiquitin specific peptidase 19 2.02725
ZNF783 zinc finger family member 783 2.02645
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma 2.0254
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.02397
ADPRH ADP-ribosylarginine hydrolase 2.02295
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2.02235
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.0209
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 2.01655
PCDHGA8 protocadherin gamma subfamily A, 8 2.0129
CTTN cortactin 2.00735

decreased expression

Symbol Name Standardized Value
ZDHHC6 zinc finger, DHHC-type containing 6 -5.4169
KRT14 keratin 14, type I -5.0
PGAM4 phosphoglycerate mutase family member 4 -4.9175
HMG20B high mobility group 20B -4.91383
KIF20A kinesin family member 20A -4.7828
COTL1 coactosin-like F-actin binding protein 1 -4.48665
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -3.41315
CEP55 centrosomal protein 55kDa -3.0806
MTERF3 mitochondrial transcription termination factor 3 -2.913
ACAA1 acetyl-CoA acyltransferase 1 -2.90445
CDA cytidine deaminase -2.8248
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -2.8182
MARCHF5 membrane associated ring-CH-type finger 5 -2.81095
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -2.78475
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -2.5978
THAP11 THAP domain containing 11 -2.5976
RIDA reactive intermediate imine deaminase A homolog -2.53455
CHUK conserved helix-loop-helix ubiquitous kinase -2.51975
P3H2 prolyl 3-hydroxylase 2 -2.4698
WBP1L WW domain binding protein 1-like -2.44095
CD34 CD34 molecule -2.37745
ZNF23 zinc finger protein 23 -2.3736
BASP1 brain abundant, membrane attached signal protein 1 -2.35965
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa -2.31093
CD320 CD320 molecule -2.28245
RAB23 RAB23, member RAS oncogene family -2.2652
KIF11 kinesin family member 11 -2.24645
RHOG ras homolog family member G -2.2072
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase -2.19245
ETNPPL ethanolamine-phosphate phospho-lyase -2.181
CHMP2B charged multivesicular body protein 2B -2.17505
TCTN3 tectonic family member 3 -2.17158
ACTA1 actin, alpha 1, skeletal muscle -2.1183
SCHIP1 schwannomin interacting protein 1 -2.1131
ZNF706 zinc finger protein 706 -2.09865
MLH1 mutL homolog 1 -2.0908
TGFBI transforming growth factor, beta-induced, 68kDa -2.08695
AVPI1 arginine vasopressin-induced 1 -2.0726
LIFR leukemia inhibitory factor receptor alpha -2.05815
NT5C2 5'-nucleotidase, cytosolic II -2.0311
REXO2 RNA exonuclease 2 -2.02885
CUTC cutC copper transporter -2.0269
EPHA2 EPH receptor A2 -2.0175
TOGARAM1 TOG array regulator of axonemal microtubules 1 -2.01175
CKM creatine kinase, muscle -2.00825
STK26 serine/threonine protein kinase 26 -2.00785
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 -2.00115
SNX7 sorting nexin 7 -2.00105