CRCGN015_MCF10A.TP53.M_24H:D14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1,1-trichloroethane, technical grade 32.81 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

212 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:D14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCDC92 coiled-coil domain containing 92 5.4832
CCP110 centriolar coiled coil protein 110kDa 4.6997
CCL2 chemokine (C-C motif) ligand 2 4.18155
CTR9 CTR9, Paf1/RNA polymerase II complex component 3.9946
WIF1 WNT inhibitory factor 1 3.92295
CH25H cholesterol 25-hydroxylase 3.6447
VGLL4 vestigial-like family member 4 3.62335
COMP cartilage oligomeric matrix protein 3.40755
SIRT3 sirtuin 3 3.36678
KLHL9 kelch-like family member 9 3.2144
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.15395
EPHA3 EPH receptor A3 2.97347
SEC61B Sec61 beta subunit 2.85465
THADA thyroid adenoma associated 2.76618
OBI1 ORC ubiquitin ligase 1 2.7498
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.70855
MRPL17 mitochondrial ribosomal protein L17 2.67445
AGR2 anterior gradient 2 2.6646
DEAF1 DEAF1 transcription factor 2.65855
SLIT2 slit homolog 2 (Drosophila) 2.6373
ARHGAP19 Rho GTPase activating protein 19 2.62685
ZNF184 zinc finger protein 184 2.6088
NCK1 NCK adaptor protein 1 2.60445
COQ8A coenzyme Q8A 2.6018
TMEM267 transmembrane protein 267 2.57745
TBC1D2 TBC1 domain family, member 2 2.5553
TALDO1 transaldolase 1 2.5531
TIAM1 T-cell lymphoma invasion and metastasis 1 2.54338
BAALC brain and acute leukemia, cytoplasmic 2.53355
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 2.531
GPM6A glycoprotein M6A 2.52185
MBIP MAP3K12 binding inhibitory protein 1 2.51705
ALG9 ALG9, alpha-1,2-mannosyltransferase 2.5118
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.50815
TMEM9B TMEM9 domain family, member B 2.48485
MEX3C mex-3 RNA binding family member C 2.4775
ZDHHC7 zinc finger, DHHC-type containing 7 2.44585
AP2M1 adaptor-related protein complex 2, mu 1 subunit 2.43395
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.42565
MEPCE methylphosphate capping enzyme 2.42405
BLVRA biliverdin reductase A 2.4202
ZNF226 zinc finger protein 226 2.4176
PHC2 polyhomeotic homolog 2 (Drosophila) 2.41395
POU4F1 POU class 4 homeobox 1 2.4115
TMPRSS11D transmembrane protease, serine 11D 2.4055
CD151 CD151 molecule (Raph blood group) 2.40195
THYN1 thymocyte nuclear protein 1 2.39865
ING1 inhibitor of growth family, member 1 2.3969
MARCHF5 membrane associated ring-CH-type finger 5 2.3949
ZNHIT1 zinc finger, HIT-type containing 1 2.37015
GLTP glycolipid transfer protein 2.3673
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.3537
RIC8A RIC8 guanine nucleotide exchange factor A 2.3486
ATP9A ATPase, class II, type 9A 2.3392
FBXO3 F-box protein 3 2.3295
ARID4A AT rich interactive domain 4A (RBP1-like) 2.31695
GPM6B glycoprotein M6B 2.2923
EMC2 ER membrane protein complex subunit 2 2.27335
IPO7 importin 7 2.27191
SNX24 sorting nexin 24 2.2542
DENND2D DENN/MADD domain containing 2D 2.25075
PMM1 phosphomannomutase 1 2.24905
FAM168A family with sequence similarity 168, member A 2.24155
CALCB calcitonin-related polypeptide beta 2.2376
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.2331
CRIPT cysteine-rich PDZ-binding protein 2.22725
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.21775
SAC3D1 SAC3 domain containing 1 2.2058
GLUL glutamate-ammonia ligase 2.20433
ZNF189 zinc finger protein 189 2.19585
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 2.19555
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 2.18875
PEX12 peroxisomal biogenesis factor 12 2.18825
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 2.18788
MAP1S microtubule-associated protein 1S 2.1767
PENK proenkephalin 2.17085
MED7 mediator complex subunit 7 2.16908
EXD2 exonuclease 3'-5' domain containing 2 2.1647
SERINC5 serine incorporator 5 2.15975
HNRNPF heterogeneous nuclear ribonucleoprotein F 2.14125
VAMP5 vesicle-associated membrane protein 5 2.14125
BTN3A2 butyrophilin, subfamily 3, member A2 2.13432
MPV17L-BMERB1 MPV17L-BMERB1 readthrough 2.1335
SIX1 SIX homeobox 1 2.129
NPC1 Niemann-Pick disease, type C1 2.11873
SLC35H1 solute carrier family 35 member H1 2.11295
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 2.1129
SIK3 SIK family kinase 3 2.10881
RBM48 RNA binding motif protein 48 2.09713
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 2.08565
COLGALT1 collagen beta(1-O)galactosyltransferase 1 2.0787
XPA xeroderma pigmentosum, complementation group A 2.0784
DPF2 D4, zinc and double PHD fingers family 2 2.0781
RMI1 RecQ mediated genome instability 1 2.07405
RPH3AL rabphilin 3A-like (without C2 domains) 2.07335
TUT7 terminal uridylyl transferase 7 2.0721
PHF2 PHD finger protein 2 2.052
PMP2 peripheral myelin protein 2 2.0309
GOLPH3L golgi phosphoprotein 3-like 2.02215
PI3 peptidase inhibitor 3, skin-derived 2.0148
SLC9D1 solute carrier family 9 member D1 2.01325
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa 2.0128
CUEDC2 CUE domain containing 2 2.011
GOLGA6L9 golgin A6 family-like 9 2.00885
MCUR1 mitochondrial calcium uniporter regulator 1 2.00535
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 2.0036
ITPKC inositol-trisphosphate 3-kinase C 2.0003

decreased expression

Symbol Name Standardized Value
PMM2 phosphomannomutase 2 -5.5777
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -4.91075
TUBB6 tubulin, beta 6 class V -4.88255
COG2 component of oligomeric golgi complex 2 -4.7821
CAB39 calcium binding protein 39 -4.75255
DNM1L dynamin 1-like -4.73445
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -4.673
LYPLA1 lysophospholipase I -3.93012
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.8301
NGRN neugrin, neurite outgrowth associated -3.7718
C1QBP complement component 1, q subcomponent binding protein -3.6199
CDC45 cell division cycle 45 -3.5902
MCAM melanoma cell adhesion molecule -3.10436
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -3.03075
PTK2 protein tyrosine kinase 2 -2.964
ITGB7 integrin, beta 7 -2.9084
TSPOAP1 TSPO associated protein 1 -2.87485
SNX7 sorting nexin 7 -2.8411
PKP2 plakophilin 2 -2.81187
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.79617
CAPRIN2 caprin family member 2 -2.75805
ACTG2 actin, gamma 2, smooth muscle, enteric -2.74035
CARD10 caspase recruitment domain family, member 10 -2.6639
ACKR3 atypical chemokine receptor 3 -2.6476
FKBP9 FK506 binding protein 9, 63 kDa -2.63555
SAMHD1 SAM domain and HD domain 1 -2.62665
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -2.62541
PPP1R17 protein phosphatase 1, regulatory subunit 17 -2.61405
QRICH1 glutamine-rich 1 -2.61235
AMIGO2 adhesion molecule with Ig-like domain 2 -2.59295
H1-4 H1.4 linker histone, cluster member -2.5518
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -2.5275
WNT7A wingless-type MMTV integration site family, member 7A -2.51645
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -2.5154
KLHL11 kelch-like family member 11 -2.50495
H1-3 H1.3 linker histone, cluster member -2.50015
NOP2 NOP2 nucleolar protein -2.472
SLC38A2 solute carrier family 38, member 2 -2.4714
OSTM1 osteopetrosis associated transmembrane protein 1 -2.41485
UPP1 uridine phosphorylase 1 -2.38155
WNT11 wingless-type MMTV integration site family, member 11 -2.37905
CAPN2 calpain 2, (m/II) large subunit -2.37827
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.3751
KLF11 Kruppel-like factor 11 -2.36135
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -2.3586
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 -2.348
LPAR3 lysophosphatidic acid receptor 3 -2.32805
MRPL15 mitochondrial ribosomal protein L15 -2.31505
PHACTR1 phosphatase and actin regulator 1 -2.31425
NLGN3 neuroligin 3 -2.3108
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa -2.28495
EBLN2 endogenous Bornavirus-like nucleoprotein 2 -2.27665
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -2.26205
PLN phospholamban -2.2471
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) -2.2399
ITGA7 integrin, alpha 7 -2.21362
CHD1L chromodomain helicase DNA binding protein 1-like -2.2039
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) -2.1968
KLK14 kallikrein-related peptidase 14 -2.1946
BMP2K BMP2 inducible kinase -2.19424
DCT dopachrome tautomerase -2.19408
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -2.1917
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 -2.1883
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.17946
PISD phosphatidylserine decarboxylase -2.17765
NEUROD1 neuronal differentiation 1 -2.1765
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -2.17375
SOCS4 suppressor of cytokine signaling 4 -2.1603
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 -2.1494
EPHA4 EPH receptor A4 -2.14905
SINHCAF SIN3-HDAC complex associated factor -2.14885
MYOG myogenin (myogenic factor 4) -2.1463
CD22 CD22 molecule -2.14625
BASP1 brain abundant, membrane attached signal protein 1 -2.141
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 -2.1309
IFI6 interferon, alpha-inducible protein 6 -2.1278
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 -2.1238
BICD1 bicaudal D homolog 1 (Drosophila) -2.1179
HOMER3 homer scaffolding protein 3 -2.11578
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.1152
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -2.0981
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 -2.0918
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.08915
NXPH4 neurexophilin 4 -2.08705
PLAAT3 phospholipase A and acyltransferase 3 -2.077
SHANK1 SH3 and multiple ankyrin repeat domains 1 -2.07293
CCL11 chemokine (C-C motif) ligand 11 -2.07085
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -2.0701
SCN2B sodium channel, voltage gated, type II beta subunit -2.0678
PYCARD PYD and CARD domain containing -2.05955
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -2.0568
TRIM11 tripartite motif containing 11 -2.05595
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.05575
ZP2 zona pellucida glycoprotein 2 (sperm receptor) -2.04455
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa -2.04437
NXPH3 neurexophilin 3 -2.04285
MRPS10 mitochondrial ribosomal protein S10 -2.03815
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 -2.03795
SGK1 serum/glucocorticoid regulated kinase 1 -2.03505
ADM2 adrenomedullin 2 -2.0332
INA internexin neuronal intermediate filament protein, alpha -2.03015
CRLF2 cytokine receptor-like factor 2 -2.0158
ADAMDEC1 ADAM-like, decysin 1 -2.00765
COPS7B COP9 signalosome subunit 7B -2.00505
EIPR1 EARP complex and GARP complex interacting protein 1 -2.0013