CRCGN015_MCF10A.TP53.M_24H:D15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1,1-trichloroethane, technical grade 10.94 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:D15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LAGE3 L antigen family, member 3 5.1021
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.0833
CXCR4 chemokine (C-X-C motif) receptor 4 4.733
IDE insulin-degrading enzyme 4.4174
HDGFL3 HDGF like 3 3.21939
NOSIP nitric oxide synthase interacting protein 3.0867
FAM3A family with sequence similarity 3, member A 2.8721
MAST2 microtubule associated serine/threonine kinase 2 2.80028
COQ8A coenzyme Q8A 2.68205
CCDC85B coiled-coil domain containing 85B 2.63245
GPHN gephyrin 2.44095
CENPE centromere protein E, 312kDa 2.39875
BNC2 basonuclin 2 2.3253
FOXL2 forkhead box L2 2.32135
WIF1 WNT inhibitory factor 1 2.20145
RANGRF RAN guanine nucleotide release factor 2.18605
FAM50A family with sequence similarity 50, member A 2.18295
PLS3 plastin 3 2.17775
APTX aprataxin 2.1443
FBXO34 F-box protein 34 2.1083
GATA4 GATA binding protein 4 2.0862
DKC1 dyskeratosis congenita 1, dyskerin 2.03275

decreased expression

Symbol Name Standardized Value
HAT1 histone acetyltransferase 1 -5.35935
GOLT1B golgi transport 1B -5.25385
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -4.49218
BAG3 BCL2-associated athanogene 3 -4.4172
KRT14 keratin 14, type I -4.26515
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.3395
BASP1 brain abundant, membrane attached signal protein 1 -3.03265
ANKRD10 ankyrin repeat domain 10 -2.76785
INTS13 integrator complex subunit 13 -2.69845
SGK1 serum/glucocorticoid regulated kinase 1 -2.6131
TP53 tumor protein p53 -2.56555
RECQL RecQ helicase-like -2.43451
SRFBP1 serum response factor binding protein 1 -2.2976
GORASP2 golgi reassembly stacking protein 2, 55kDa -2.24157
ZHX2 zinc fingers and homeoboxes 2 -2.2105
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.20273
REXO2 RNA exonuclease 2 -2.18899
PCCB propionyl CoA carboxylase, beta polypeptide -2.1825
CYBRD1 cytochrome b reductase 1 -2.17595
CD81 CD81 molecule -2.1754
SFXN1 sideroflexin 1 -2.08765
SMIM10L1 small integral membrane protein 10 like 1 -2.0864
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 -2.0581
OMG oligodendrocyte myelin glycoprotein -2.00625