CRCGN015_MCF10A.TP53.M_24H:D16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-butyl chloride 102.99 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:D16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FKBP14 FK506 binding protein 14, 22 kDa 5.49965
SNAP25 synaptosomal-associated protein, 25kDa 4.3412
WIF1 WNT inhibitory factor 1 4.2743
HBA1 hemoglobin, alpha 1 3.4539
HLA-DRA major histocompatibility complex, class II, DR alpha 3.22417
SCG3 secretogranin III 3.1699
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.8339
RABEPK Rab9 effector protein with kelch motifs 2.57255
STMN4 stathmin-like 4 2.5552
MOK MOK protein kinase 2.51355
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.357
MECR mitochondrial trans-2-enoyl-CoA reductase 2.3473
COPS7A COP9 signalosome subunit 7A 2.3235
NKX2-2 NK2 homeobox 2 2.2674
NSG2 neuronal vesicle trafficking associated 2 2.23985
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.1701
APLP1 amyloid beta (A4) precursor-like protein 1 2.05115
MCUR1 mitochondrial calcium uniporter regulator 1 2.04585
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 2.03777
SLC31A1 solute carrier family 31 (copper transporter), member 1 2.0366
BIRC2 baculoviral IAP repeat containing 2 2.029
CPZ carboxypeptidase Z 2.0012

decreased expression

Symbol Name Standardized Value
SGK1 serum/glucocorticoid regulated kinase 1 -5.7673
TCTA T-cell leukemia translocation altered -5.1778
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -5.17625
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -5.055
DYNLT3 dynein, light chain, Tctex-type 3 -4.84685
C2CD5 C2 calcium-dependent domain containing 5 -4.7424
PUF60 poly-U binding splicing factor 60KDa -4.68365
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.7391
MRPL30 mitochondrial ribosomal protein L30 -2.71145
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.69064
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -2.57352
SCRIB scribbled planar cell polarity protein -2.46945
ANTKMT adenine nucleotide translocase lysine methyltransferase -2.36055
RHOT2 ras homolog family member T2 -2.32865
NGRN neugrin, neurite outgrowth associated -2.30875
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.3077
THAP11 THAP domain containing 11 -2.2684
ATP11B ATPase, class VI, type 11B -2.1133
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.1013
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -2.05585
TUBA4A tubulin, alpha 4a -2.0104