CRCGN015_MCF10A.TP53.M_24H:D18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-butyl chloride 11.44 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

20 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:D18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCR4 chemokine (C-X-C motif) receptor 4 5.52785
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 3.66645
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.6433
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.4539
TLCD3A TLC domain containing 3A 2.69465
PDLIM1 PDZ and LIM domain 1 2.4083
CAPN1 calpain 1, (mu/I) large subunit 2.34055
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.32865
ZMIZ1 zinc finger, MIZ-type containing 1 2.23955
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.01535

decreased expression

Symbol Name Standardized Value
CDC25B cell division cycle 25B -5.0858
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.4876
RALGDS ral guanine nucleotide dissociation stimulator -2.91035
TBCB tubulin folding cofactor B -2.89668
DUSP4 dual specificity phosphatase 4 -2.45967
PDCD5 programmed cell death 5 -2.36835
KDM3A lysine (K)-specific demethylase 3A -2.33465
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.1446
PRPF38B pre-mRNA processing factor 38B -2.0335
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.01542