CRCGN015_MCF10A.TP53.M_24H:D20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description coumophos 32.42 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN015_MCF10A.TP53.M_24H:D20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.2474
NOSIP nitric oxide synthase interacting protein 3.16525
SYNGAP1 synaptic Ras GTPase activating protein 1 2.66282
CCDC85B coiled-coil domain containing 85B 2.65145
TRIM24 tripartite motif containing 24 2.45095
RPAP1 RNA polymerase II associated protein 1 2.2828
CYREN cell cycle regulator of NHEJ 2.2628
RBX1 ring-box 1, E3 ubiquitin protein ligase 2.25545
BMP6 bone morphogenetic protein 6 2.19185
RNF111 ring finger protein 111 2.16045
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 2.1519
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) 2.13675
LYRM1 LYR motif containing 1 2.1247
MRPL17 mitochondrial ribosomal protein L17 2.10515
MCUB mitochondrial calcium uniporter dominant negative subunit beta 2.0957
MCUR1 mitochondrial calcium uniporter regulator 1 2.08985
TOPBP1 topoisomerase (DNA) II binding protein 1 2.04285

decreased expression

Symbol Name Standardized Value
ANKRD10 ankyrin repeat domain 10 -7.70605
PRPF4 pre-mRNA processing factor 4 -5.53425
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.39335
LDHD lactate dehydrogenase D -5.1094
TEX10 testis expressed 10 -4.80055
NPDC1 neural proliferation, differentiation and control, 1 -4.51745
KRT14 keratin 14, type I -4.38925
GADD45B growth arrest and DNA-damage-inducible, beta -4.2455
RALGDS ral guanine nucleotide dissociation stimulator -4.02217
SLC31A1 solute carrier family 31 (copper transporter), member 1 -3.2734
TLK2 tousled-like kinase 2 -3.25325
HOXA5 homeobox A5 -2.90335
BSPRY B-box and SPRY domain containing -2.72445
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -2.67125
NAMPT nicotinamide phosphoribosyltransferase -2.64725
TUFT1 tuftelin 1 -2.58075
LGALS7B lectin, galactoside-binding, soluble, 7B -2.51275
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.49225
CPT1B carnitine palmitoyltransferase 1B (muscle) -2.48768
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) -2.42275
GATAD1 GATA zinc finger domain containing 1 -2.36805
PILRB paired immunoglobin-like type 2 receptor beta -2.3388
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 -2.30585
DOLPP1 dolichyldiphosphatase 1 -2.2682
FOSL2 FOS-like antigen 2 -2.26795
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -2.16875
INAVA innate immunity activator -2.15305
CDK9 cyclin-dependent kinase 9 -2.1499
AOPEP aminopeptidase O (putative) -2.13585
NANS N-acetylneuraminic acid synthase -2.1162
L2HGDH L-2-hydroxyglutarate dehydrogenase -2.0963
FBLN2 fibulin 2 -2.0861
AOC1 amine oxidase, copper containing 1 -2.0847
IFRD1 interferon-related developmental regulator 1 -2.08285
MRPS10 mitochondrial ribosomal protein S10 -2.07275
R3HDM2 R3H domain containing 2 -2.07075
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.0629
MXRA8 matrix-remodelling associated 8 -2.06275
PCCA propionyl CoA carboxylase, alpha polypeptide -2.0538
KIF3A kinesin family member 3A -2.03995
HCAR3 hydroxycarboxylic acid receptor 3 -2.0227
ZDHHC11B zinc finger, DHHC-type containing 11B -2.01725
FNBP1 formin binding protein 1 -2.01085
SUGP2 SURP and G patch domain containing 2 -2.01028
INSIG1 insulin induced gene 1 -2.00355